LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes

International Journal of Radiation Biology

Volumn 74, Issue 1, 1998, Pages 17-25

  Bauchinger, M ^a   Schmid, E ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA;

ARTICLE; CELL CYCLE G1 PHASE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CYTOGENETICS; DNA STRAND BREAKAGE; GENE DELETION; HUMAN; HUMAN CELL; INTERPHASE; IONIZING RADIATION; LYMPHOCYTE CULTURE; PRIORITY JOURNAL; RADIATION INJURY;

ALPHA PARTICLES; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; HUMANS; LINEAR ENERGY TRANSFER; LYMPHOCYTES; NEUTRONS; PROTONS; X-RAYS;

EID: 0031827943     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098141681     Document Type: Article

References (33)

1. BAUCHINGER, M. and GOTZ, G., 1979, Distribution of radiation induced lesions in human chromosomes and dose-effect relation analysed with G-banding. Radiation and Environmental Biophysics, 16, 355-366.
2. BAUCHINGER, M., KOESTER, L., SCHMID, E., DRESP, J. and STRENG, S., 1984, Chromosome aberrations in human lymphocytes induced by fission neutrons. International Journal of Radiation Biology, 45, 449-457.
3. BAUCHINGER, M., KUHN, H., DRESP, J., SCHMID, E. and STRENG, S., 1983, Dose-effect relationship for 14.5 MeV (d + T) neutron-induced chromosome aberrations in human lymphocyte irradiated in a man phantom. International Journal of Radiation Biology, 43, 571-578.
4. BAUCHINGER, M. and SCHMID, E., 1997, Is there reliable experimental evidence for a chromosomal 'fingerprint' of exposure to densely ionizing radiation? Radiation Research, 147, 506-510.
5. BRENNER, D. J., 1996, Direct biological evidence for significant neutron dose to survivors of the Hiroshima atomic bomb. Radiation Research.,145, 501-507.
6. BRENNER, D. J. and SACHS, R. K., 1994, Chromosomal 'fingerprints' of prior exposure to densely-ionixing radiation. Radiation Research, 140, 134-142.
7. BRENNER, D. J. and SACHS, R. K., 1996a, Comments on 'Comment on the ratio of chromosome-type dicentric interchanges to centric rings for track-clustered compared to random breaks' by Savage and Papworth. Radiation Research, 146, 241-242.
8. BRENNER, D. J. and SACHS, R. K., 1996b, Response to 'Comments on "Direct biological evidence for a significant neutron dose to survivors of the Hiroshima atomic bomb'" by E. Schmid and M. Bauchinger. Radiation Research, 146, 481-482.
9. CHADWICK, K. H. and LEENHOUTS, H. P., 1981, The Molecular Theory of Radiation Biology (Berlin: Springer-Verlag).
10. CHEN, A. M., LUCAS, J. N., HILL, F. S., BRENNER, D. J. and SACHS, R. K., 1996, Proximity effects for chromosome aberrations measured by FISH. International Journal of Radiation Biology, 69, 411-420.
11. CHEN, A. M., LUCAS, J. N., SIMPSON, P. J., GRIFFIN, C. S., SAVAGE, J. R. K., BRENNER, D. J., HLATKY, L. R. and SACHS, R. K., 1997, Computer simulation of data on chromosome aberrations produced by x-rays or alpha particles and detected by fluorescence in situ hybridization. Radiation Research, 148, S93-S101.
12. CORNFORTH, M. N. and BEDFORD, J. S., 1987, A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiation Research, 111, 385-405.
13. CREMER, T., KURZ, A., ZIRBEL, R., et al., 1993, Role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symposia on Quantitative Biology, 58, 777-792.
14. CREMER, C., MUNKEL, CH., GRANZOW, M., et al., 1996, Nuclear architecture and the induction of chromosomal aberrations. Mutation Research, 366, 97-116.
15. DURANTE, M., GROSSI, G. F., GIALANELLA, G., PUGLIESA, M., NAPPO, M. and YANG, T. C., 1995, Effects of alpha-particles on survival and chromosomal aberrations in human mammary epithelial cells. Radiation and Environmental Biophysics, 34, 195-204.
16. HAHNFELDT, P., HLATKY, L. R., BRENNER, D. J. and SACHS, R. K., 1995, Chromosome aberrations produced by radiation: the relationship between excess acentric fragments and dicentrics. Radiation Research, 141, 136-152.
17. HLATKY, L. R., SACHS, R. K. and HAHNFELDT, P., 1992, The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation. Radiation Research, 129, 304-308.
18. RIMPL, G. R., SCHMID, E., BRASELMANN, H. and BAUCHINGER, M., 1990, Chromosome aberrations induced in human lymphocytes by 16.5 MeV protons. International Journal of Radiation Biology, 58, 999-1007.
19. ROOS, H. and SCHMID, E., 1997, Analysis of chromosome aberrations in human lymphocytes induced by 5.4 keV x-rays. Radiation and Environmental Biophysics, 36, 251-254.
20. SACHS, R. K., CHEN, A. M. and BRENNER, D. J., 1997a, Review: proximity effects in the production of chromosome aberrations by ionizing radiation. International Journal of Radiation Biology, 71, 1-19.
21. SACHS, R. K., BRENNER, D. J., CHEN, A. M., HAHNFELDT, P. and HLATKY, L. R., 1997b, Intra-arm and interarm chromosome intrachanges: tools for probing the geometry and dynamics chromatin. Radiation Research, 148, 330-340.
22. SAVAGE, J. R. K., 1970, Sites of radiation induced chromosome exchanges. Current Topics in Radiation Research, VI, 129-194.
23. SAVAGE, J. R. K., 1996, Insight into sites. Mutation Research, 366, 81-95.
24. SAVAGE, J. R. K. and PAPWORTH, D. G., 1996, Comment on the ratio of chromosome-type dicentric interchanges to centric rings for track-clustered compared with random breaks. Radiation Research, 146, 236-240.
25. SAX, K., 1940, An analysis of X-ray induced chromosomal aberrations in Tradescantia. Genetics, 25, 41-68.
26. SCHMID, E. and BAUCHINGER, M., 1996, Comments on 'Direct biological evidence for a significant neutron dose to survivors of the Hiroshima atomic bomb' by D. J. Brenner. Radiation Research, 146, 479-481.
27. SCHMID, E., BAUCHINGER, M., STRENG, S. and NAHRSTEDT, U., 1984, The effect of 220 kVp X-rays with different spectra on the dose response of chromosome aberrations in human lymphocytes. Radiation and Environmental Biophysics, 23, 305-309.
28. SCHMID, E., BRASELMANN, H. and NAHRSTEDT, U., 1995, Comparison of γ-ray induced dicentric yields in human lymphocytes measured by conventional analysis and FISH. Mutation Research, 348, 125-130.
29. SCHMID, E., HIEBER, L., HEINZMANN, U., ROOS, H. and KELLERER, A. M., 1996, Analysis of chromosome aberrations in human peripheral lymphocytes induced by in vitro α-particle irradiation. Radiation and Environmental Biophysics, 35, 179-184.
30. SCHMID, E., ROOS, H., RIMPL, G. and BAUCHINGER, M., 1997, Chromosome aberration frequencies in human lymphocytes irradiated in a multi-layer array by protons with different LET. International Journal of Radiation Biology, 72, 661-665.
31. SCHMID, E., SCHRAUBE, H. and BAUCHINGER, M., 1998, Chromosome aberration frequencies in human lymphocytes irradiated in a phantom by a mixed beam of fission neutrons and γ-rays. International Journal of Radiation Biology, in press.
32. WU, H., DURANTE, M., SACHS, R. K. and YANG, T. C., 1997, Centric rings, acentric rings and excess acentric fragments based on a random walk interphase chromosome model. International Journal of Radiation Biology, 71, 487-496.
33. 1 interphase nucleus. Journal of Cell Biology, 130, 1239-1249.