A comparative study on potential cytogenetic fingerprints for radiation LET in human lymphocytes

International Journal of Radiation Biology

Volumn 76, Issue 12, 2000, Pages 1589-1598

  Deng, W ^a   Morrison, D P ^a   Gale, K L ^a   Lucas, J N ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMATID EXCHANGE; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHROMOSOME INSERTION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOGENETICS; DNA FINGERPRINTING; GAMMA IRRADIATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LINEAR ENERGY TRANSFER; LYMPHOCYTE; MALE; METAPHASE; NEUTRON RADIATION; NORMAL HUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION ENERGY; TELOMERE;

EID: 0033639194     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000050201073     Document Type: Article

References (34)

1. Is there reliable experimental evidence for a chromosomal 'fingerprint' of exposure to densely ionizing radiation?
2. LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes
3. Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric PNA probe
4. Separation of leukocytes from blood and bone marrow
5. Chromosomal 'fingerprints' of prior exposure to densely ionizing radiation
6. Nuclear architecture and the formation of chromosome aberrations
7. Nuclear architecture and induction of chromsomal aberration
8. Combined FISH with pantelomeric PNA and whole chromosome specific DNA probes to detect complete and incomplete chromosome exchanges in human lymphocytes
9. Biological dosimetry of beta-ray exposure from tritium using chromosome translocations in human lymphocytes analysed by fluorescence in situ hybridization
10. Three-dimensional reconstruction of painted human interphase chromosomes: Active and inactive X chromosome territories have similar volumes but differ in shape and surface structure
11. Effects of radiation of different qualities on cells: Molecular mechanisms of damage and repair
12. Frequencies of complex chromosome exchange aberrations induced by 238Pu a-particles and detected by fluorescence in situ hybridization using single chromosome-specific probes
13. Frequencies and types of exchange aberrations induced by X-rays and neutrons in Chinese hamster splenocytes detected by FISH using chromosome-specific DNA libraries
14. Telomere shorten during ageing of human fibroblasts
15. Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following γ-and α-irradiation
16. Specific association of human telomerase activity with immortal cells and cancer cells
17. Estimation of minimum size of translocated chromosome segments detected by fluorescence in situ hybridization
18. Heterogeneity in telomere length of human chromosomes
19. Cytogenetic signature for ionizing radiation
20. Theoretical and experimental tests of a chromosomal fingerprint for densely ionizing radiation based on F ratios calculated from stable chromosome aberrations
21. Report on a workshop to examine methods to arrive at risk estimates for radiation-induced cancer in human based on laboratory data
22. Chromosome healing: Spontaneous and programmed de novo telomere formation by telomerase
23. New approaches for biological monitoring of radiation workers
24. Biological indicators for radiation damage
25. F Values as cytogenetic fingerprints of prior exposure to different radiation qualities: Prediction, reality and future
26. Chromosome aberrations in human fibroblasts induced by monoenergetic neutrons. I. Relative biological effectiveness
27. Intra-arm and inter-arm chromosome intrachanges: Tools for probing the geometry and dynamics of chromatin
28. Chromosome healing, telomere capture and mechanisms of radiation-induced chromosome breakage
29. Rejoining of DNA double-strand breaks induced by accelerated nitrogen ions
30. De novo telomere addition by Tetrahymena telomerase in vitro
31. Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes
32. Estimate of the frequency of true incomplete exchanges in human lymphocytes exposed to 1 GeV/u Fe ions in vitro