Cardiomyocyte hyperplasia after plasmid- mediated vascular endothelial growth factor gene transfer in pigs with chronic myocardial ischemia

Journal of Gene Medicine

Volumn 6, Issue 2, 2004, Pages 222-227

  Laguens, Rubén ^a,b   Meckert, Patricia Cabeza ^b,c   Janavel, Gustavo Vera ^a,d   De Lorenzi, Andrea ^b   Lascano, Elena ^a   Negroni, Jorge ^a   del Valle, Héctor ^a   Cuniberti, Luis ^a   Martínez, Verónica ^a   Dulbecco, Eduardo ^b   Melo, Carlos ^d   Fernández, Nahuel ^d   Criscuolo, Marcelo ^d   Crottogini, Alberto ^a  

^a FAVALORO UNIVERSITY   (Argentina)

^b HOSPITAL UNIVERSITARIO FUNDACIÓN FAVALORO   (Argentina)

^c Universidad Provincial del Sudoeste   (Argentina)

^d Bio Sidus   (Argentina)

Author keywords

Cardiomyocyte hyperplasia; Cytokinesis; Myocardial ischemia; Myocyte proliferation; Pigs; VEGF

Indexed keywords

PLASMID VECTOR; VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL HYPERPLASIA; CELL LOSS; CELL SIZE; CHRONIC DISEASE; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CYTOKINESIS; DATA ANALYSIS; ECHOCARDIOGRAPHY; GENE TRANSFER; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART WEIGHT; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; REOPERATION; SWINE; TISSUE SECTION; ANIMAL; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMEROIDEA;

ANIMALS; GENE TRANSFER TECHNIQUES; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 4644306284     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.478     Document Type: Article

References (21)

1. 165 gene transfer. Gene Ther 2002; 9 1676-1681.
2. Linzbach AJ. Heart failure from the point of view of quantitative anatomy. Am J Cardiol 1960; 5: 370-382.
3. Grajek S, Lesiak M, Pyda M, et al. Hypertrophy or hyperplasia in cardiac muscle. Post-mortem human morphometric study. Eur Heart J 1993; 14: 40-47.
4. Beltrami AP, Urbanek K, Kajstura J, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Eng J Med 2001; 344: 1750-1757.
5. Kajstura J, Leri A, Finato N, et al. Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci U S A 1998; 95: 8801-8805.
6. Limana F, Urbanek K, Chimenti S, et al. bcl-2 overexpression promotes myocyte proliferation. Proc Natl Acad Sci U S A 2002; 99: 6257-6262.
7. Gerdes AM, Onodera T, Tamura T, et al. New method to evaluate myocyte remodeling from formalin-fixed biopsy and autopsy material. J Card Fail 1998; 4: 343-348.
8. Taylor DA, Atkins BZ, Hungspreugs P, et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med 1998; 4: 929-933 [Erratum in: Nat Med 1998; 4: 1200].
9. Jain M, DerSimonian H, Brenner DA, et al. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation 2001; 103 1920-1927.
10. Ghostine S, Carrion C, Souza LC, et al. Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction. Circulation 2002; 106: I-131-I-136.
11. Sakai T, Li RK, Weisel RD, et al. Fetal cell transplantation: a comparison of three cell types. J Thorac Cardiovasc Surg 1999; 118: 715-724.
12. Li RK, Weisel RD, Mickle DA, et al. Autologous porcine heart cell transplantation improved heart function after a myocardial infarction. J Thorac Cardiovasc Surg 2000; 119: 62-68.
13. Klug MG, Soonpaa MH, Koh GY, Field LJ. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 1996; 98: 216-224.
14. Hescheler J, Fleischmann BK, Lentini S, et al. Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 1997; 36: 149-162.
15. Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001; 107: 1395-1402 [Comment in: J Clin Invest 2001; 107: 1355-1356].
16. Orlic D, Kajstura J, Chimenti S, et al. Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann N Y Acad Sci 2001; 938: 221-230.
17. Orlic D. Adult bone marrow stem cells regenerate myocardium in ischemic heart disease. Ann N Y Acad Sci 2003; 996: 152-157.
18. Gräbner W, Pfitzer P. Number of nuclei in isolated myocardial cells of pigs. Virchows Arch B Cell Pathol 1974; 15 279-294.
19. Olivetti G, Cigola E, Maestri R, et al. Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart. J Mol Cell Cardiol 1996; 28: 1463-1477.
20. Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106: 1913-1918.
21. Chiu RC. Therapeutic cardiac angiogenesis and myogenesis: the promises and challenges on a new frontier. J Thorac Cardiovasc Surg 2001; 122: 851-852.