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2Ph, CN, etc.) as well as an eventual intramolecular nucleophilic N-C bond formation.
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0037174410
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For a similar approach to the Vinca alkaloids using a tandem intramolecular Diels-Alder/dipolar cycloaddition sequence of a 1,3,4-oxadiazole across the indole double bond, see: Wilkie, G. D.; Elliott, G. I.; Blagg, B. S.; Wolkenberg, S. E.; Soenen, D. R.; Miller, M. M.; Pollack, S.; Boger, D. L. J. Am. Chem. Soc. 2002, 124, 11292.
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35
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4644275597
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note
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Conversion of 21 to 22 was previously described in ref 13.
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