High-frequency of quinolone-resistant Neisseria gonorrhoeae in Austria with a common pattern of triple mutations in GyrA and ParC genes

Sexually Transmitted Diseases

Volumn 31, Issue 10, 2004, Pages 616-618

  Uthman, Aumaid ^a   Heller Vitouch, Claudia ^a   Stary, Angelika ^c   Bilina, Anette ^c   Kuchinka Koch, Angelika ^c   Söltz Szöts, Josef ^a   Tschachler, Erwin ^a,b  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b Universitatsklinik fur Dermatologie   (Austria)

^c Outpatients' Ctr Diagn Infect V   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AZITHROMYCIN; CEFALEXIN; CEFIXIME; CEFTRIAXONE; CIPROFLOXACIN; COTRIMOXAZOLE; DNA TOPOISOMERASE (ATP HYDROLYSING) A; ERYTHROMYCIN; NETILMICIN; NORFLOXACIN; OFLOXACIN; PENICILLIN G; PROTEIN PARC; QUINOLONE; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; AUSTRIA; BACTERIAL INFECTION; BACTERIUM ISOLATE; HUMAN; NEISSERIA GONORRHOEAE; NONHUMAN; PHENOTYPE; POINT MUTATION;

EID: 4644298033     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.olq.0000140019.18390.28     Document Type: Article

References (21)

1. Gransden WR, Warren CA, Phillips I, et al. Decreased susceptibility of Neisseria gonorrhoeae to ciprofloxacin. Lancet 1990; 335:51.
2. Birley H, McDonald P, Carey P, et al. High level ciprofloxacin resistance in Neisseria gonorrhoeae. Genitourin Med 1994; 70:292-293.
3. Tapsall JW, Phillips EA, Shultz TZ, et al. Quinolone-resistant Neisseria gonorrhoeae isolated in Sydney, Australia, 1991. Sex Transm Dis 1996; 23:425-428.
4. Kam KM, Wong PW, Cheung MM, et al. Quinolone-resistant Neisseria gonorrhoeae in Hong Kong. Sex Transm Dis 1996; 23:103-108.
5. Deguchi T, Yasuda M, Asano M, et al. DNA Gyrase mutation in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother 1995; 39:561-563.
6. Khodursky AB, Cozzarelli NR. The mechanism of inhibition of topoisomerase IV by quinolone antibacterials. J Biol Chem 1998; 273:27668-27677.
7. Drlica K. Mechanism of fluoroquinolone action. Curr Opin Microbiol 1999; 2:504-508.
8. Belland RJ, Morrison SG, Ison C, et al. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol Microbiol 1994; 14:371-380.
9. Marians KJ, Hiasa H. Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV. J Biol Chem 1997; 272:9401-9409.
10. Deguchi T, Yasuda M, Maeda SI, et al. Serotyping of quinolone-resistant Neisseria gonorrhoeae isolates with alterations in GyrA and ParC. J Antimicrob Chemother 1998; 41:418-420.
11. Deguchi T, Yasuda M, Nakano M, et al. Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA Gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother 1996; 40:1020-1023.
12. Trees DL, Sandul AL, Neal SW, et al. Molecular epidemiology of Neisseria gonorrhoeae exhibiting decreases susceptibility and resistance to ciprofloxacin in Hawaii, 1991-1999. Sex Transm Dis 2001; 28:309-314.
13. Su X, Lind I. Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains isolated in Denmark from 1995-1998. Antimicrob Agents Chemother 2001; 45:117-123.
14. Chaudhry U, Ray K, Bala M, et al. Mutation pattern in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect 2002; 78:440-444.
15. Trees DL, Sandul AL, Peto-Mesola V, et al. Alteration within the quinolone resistance-determining regions of GyrA and ParC of Neisseria gonorrhoeae isolates in the Far East and the United States. Int J Antimicrob Agents 1999; 12:325-332.
16. Trees DL, Sirivongrangson P, Schultz AJ, et al. Multiclonal increase in ciprofloxacin-resistant Neisseria gonorrhoeae, Thailand, 1998-1999. Sex Transm Dis 2002; 29:668-673.
17. Rice RJ, Knapp JS. Antimicrobial susceptibility of Neisseria gonorrhoeae strains representing five distinct resistance phenotypes. Antimicrob Agents Chemother 1994; 38:155-158.
18. Performance standard for antimicrobial susceptibility testing. 12th Informational Supplement NCCLS Document M100-S12, Villanova, PA: NCCLS; January 2002.
19. Deguchi T, Yasuda M, Nakano M, et al. Rapid detection of point mutations of the Neisseria gonorrhoeae GyrA gene associated with decreased susceptibilities to quinolones. J Clin Microbiol 1996; 34:2255-2258.
20. Deguchi T, Yasuda M, Nakano M, et al. Rapid screening of point mutations of the Neisseria gonorrhoeae parC gene associated with resistance to quinolones. J Clin Microbiol 1997; 35:948-950.
21. Kam KM, Kam SSY, Cheung DTL, et al. Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong. Antimicrob Agents Chemother 2003; 47:436-439.