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The use of 0.05% trifluoroacetic acid as a modifier resulted in hydrolysis of the pinacol ester functionality, during HPLC analysis.
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46
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4644252229
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note
-
Typical Aqueous Workup. After completion of the reaction, the solvent was removed and the residue was taken up in ether. The ether was extracted with 2 N NaOH, and the combined aqueous layers were washed with ether. The aqueous layer was then acidified to pH 4, and the resulting precipitate was collected.
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