Predictive and prognostic role of E-cadherin protein expression in patients with advanced gastric carcinomas treated with palliative chemotherapy

Tumor Biology

Volumn 25, Issue 3, 2004, Pages 106-110

  Graziano, Francesco ^a,b   Mandolesi, Alessandra ^c   Ruzzo, Annamaria ^b   Bearzi, Italo ^c   Testa, Enrica ^a   Arduini, Federica ^c   Silva, Rosarita ^d   Muretto, Pietro ^e   Mari, Davide ^d   Berardi, Rossana ^c   Scartozzi, Mario ^c   Lai, Vittorio ^a   Cascinu, Stefano ^c   Magnani, Mauro ^b  

^a Hospital of Urbino   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d Fabriano Hospital   (Italy)

^e SAN SALVATORE HOSPITAL   (Italy)

Author keywords

Chemotherapy; E cadherin; Gastric cancer; Prognosis

Indexed keywords

CISPLATIN; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; UVOMORULIN; ANTINEOPLASTIC AGENT; CADHERIN; TUMOR MARKER;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG RESPONSE; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; STOMACH CARCINOMA; TREATMENT OUTCOME; VISCERAL METASTASIS; BIOSYNTHESIS; CARCINOMA; CLINICAL TRIAL; GENETICS; MIDDLE AGED; PALLIATIVE THERAPY; PATHOLOGY; PREDICTION AND FORECASTING; RETROSPECTIVE STUDY; STOMACH TUMOR; SURVIVAL;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CADHERINS; CARCINOMA; CISPLATIN; EPIRUBICIN; FEMALE; FLUOROURACIL; HUMANS; IMMUNOHISTOCHEMISTRY; LEUCOVORIN; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PALLIATIVE CARE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 4644289742     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079141     Document Type: Article

References (25)

1. Christofori G, Semb H: The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 1999;24:73-76.
2. Graziano F, Humar B, Guilford P: The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice. Ann Oncol 2003;14:1705-1713.
3. Berx G, Becker KF, Hofler H, van Roy F: Mutations of the human E-cadherin (CDH1) gene. Hum Mutat 1998;12:226-237.
4. Becker KF, Hofler H: Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas. J Natl Cancer Inst 1995;87:1082-1084.
5. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-2054.
6. Shun CT, Wu MS, Lin JT, Wang HP, Houng RL, Lee WJ, Wang TH, Chuang SM: An immunohistochemical study of E-cadherin expression with correlations to clinicopathological features in gastric cancer Hepatogastroenterology 1998;45:944-949.
7. Jawhari A, Jordan S, Poole S, Browne P, Pignatelli M, Farthing MJ: Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival. Gastroenterology 1997;112:46-54.
8. Gabbert HE, Mueller W, Schneiders A, Meirer S, Moll R, Birchmeier W, Hommel G: Prognostic value of E-cadherin expression in 413 gastric carcinomas. Int J Cancer 1996;69:184-189.
9. Shino Y, Watanabe A, Yamada Y, Tanase M, Yamada T, Matsuda M, Yamashita J, Tatsumi M, Miwa T, Nakano H: Clinicopathologic evaluation of immunohistochemical E-cadherin expression in human gastric carcinomas. Cancer 1995;76:2193-2201.
10. Yonemura Y, Ninomiya I, Kaji M, Sugiyama K, Fujimura T, Tsuchihara K, Kawamura T, Miyazaki I, Endou Y, Tanaka M, Sasaki T: Decreased E-cadherin expression correlates with poor survival in patients with gastric cancer. Anal Cell Pathol 1995;8:177-190.
11. Joo YE, Park CS, Kim HS, Choi SK, Rew JS, Kim SJ: Prognostic significance of E-cadherin/catenin complex expression in gastric cancer. J Korean Med Sci 2000;15:655-666.
12. Yonemura Y, Endou Y, Kimura K, Fushida S, Bandou E, Taniguchi K, Kinoshita K, Ninomiya I, Sugiyama K, Heizmann CW, Schafer BW, Sasaki T: Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer. Clin Cancer Res 2000;6:4234-4242.
13. Nakamura T, Kato Y, Fuji H, Horiuchi T, Chiba Y, Tanaka K: E-cadherin-dependent intercellular adhesion enhances chemoresistance. Int J Mol Med 2003;12:693-700.
14. Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 1981;47:207-214.
15. Cascinu S, Labianca R, Graziano F, Pancera G, Barni S, Frontini L, Luporini G, Cellerino R, Catalano G: Intensive weekly chemotherapy for locally advanced gastric cancer using 5-fluorouracil, cisplatin, epidoxorubicin, 6S-leucovorin, glutathione and filgrastim: A report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). Br J Cancer 1998;78:390-393.
16. Graziano F, Santini D, Testa E, Catalano V, Beretta GD, Mosconi S, Tonini G, Lai V, Labianca R, Cascinu S: A phase II study of weekly cisplatin, 6S-stereoisomer leucovorin and fluorouracil as first-line chemotherapy for elderly patients with advanced gastric cancer. Br J Cancer 2003;89:1428-1432.
17. Tsai JY, Safran H: Status of treatment for advanced gastric cancer. Curr Oncol Rep 2003;5:210-218.
18. Chabner BA, Boral AL, Multani P: Translational research: Walking the bridge between idea and cure - Seventeenth Bruce F. Cain Memorial Award lecture. Cancer Res 1998;58:4211-4216.
19. Tas F, Aykan NF, Aydiner A, Uygun K, Basaran M, Camlica H, Topuz E: The roles of chemotherapy and surgery in gastric carcinoma and the influence of prognostic factors on survival. Am J Clin Oncol 2000;23:53-57.
20. Tahara M, Ochiai A, Fujimoto J, Boku N, Yasui W, Ohtsu A, Tahara E, Yoshida S: Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil. Oncol Rep 2004;11:9-15.
21. Boku N, Chin K, Hosokawa K, Ohtsu A, Tajiri H, Yoshida S, Yamao T, Kondo H, Shirao K, Shimada Y, Saito D, Hasebe T, Mukai K, Seki S, Saito H, Johnston PG: Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cisplatinum. Clin Cancer Res 1998;4:1469-1474.
22. Tannock IF: Tumor physiology and drug resistance. Cancer Metastasis Rev 2001;20:123-132.
23. Gunji N, Oda T, Todoroki T, Kanazawa N, Kawamoto T, Yuzawa K, Scarpa A, Fukao K: Pancreatic carcinoma: Correlation between E-cadherin and alpha-catenin expression status and liver metastasis. Cancer 1998;82:1649-1656.
24. Kanazawa N, Oda T, Gunji N, Nozue M, Kawamoto T, Todoroki T, Fukao K: E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer. Surg Today 2002;32:123-128.
25. Cheng JC, Matsen CB, Gonzales FA, Ye W, Greer S, Marquez VE, Jones PA, Selker EU: Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst 2003;95:399-409.