Prognostic value of E-cadherin expression in 413 gastric carcinomas

International Journal of Cancer

Volumn 69, Issue 3, 1996, Pages 184-189

  Gabbert, Helmut E ^a   Mueller, Wolfram ^a   Schneiders, Anke ^a   Meier, Stephanie ^a   Moll, Roland ^b   Birchmeier, Walter ^c   Hommel, Gerd ^d  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; UVOMORULIN;

ADULT; AGED; ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; STOMACH CARCINOMA; SURVIVAL RATE; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CADHERINS; FEMALE; FOLLOW-UP STUDIES; FORMALDEHYDE; HUMANS; MALE; MIDDLE AGED; PARAFFIN EMBEDDING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0030054482     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960621)69:3<184::AID-IJC6>3.0.CO;2-W     Document Type: Article

References (35)

1. BECKER, K.F., ATKINSON, M.J., REICH, U., HUANG, H.H., NEKARDA, H., SIEWERT, J.R. and HÖFLER, H., Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum. mol. Genet., 2, 803-804 (1993).
2. BEHRENS, J., MAREEL, M.M., VAN ROY, P.M., BIRCHMEIER, W., Dissecting tumor cell invasion: epithelial cells acquire invasive properties after loss of Uvomorulin-mediated cell-cell adhesion. J. Cell Biol., 108, 2435-2447 (1989).
3. BEHRENS, J., VAKAET, L., FRIIS, R., WINTERHAGER, E., VAN ROY, V.F., MAREEL, M. and BIRCHMEIER, W., Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-src gene. J. Cell Biol., 120, 757-766 (1993).
4. BRINGUIER, P.P., UMBAS, R., SCHAAFSMA, E., KARTHAUS, H.F.M., DEBRUYNE, F.M.J. and SCHALKEN, J.A., Decreased E-cadherin immu- noreactivity correlates with poor survival in patients with bladder tumors. Cancer Res., 53, 3241-3245 (1993).
5. EIDELMAN, S., DAMSKY, C.H., WHEELOCK, M.J. and DAMJANOV, I., Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors. Amer. J. Pathol., 135, 101-110 (1989).
6. FRIXEN, U.H., BEHRENS, J., SACHS, M., EBERLE, G., VOSS, B., WARDA, A., LOCKNER, D., BIRCHMEIER, W., E-cadherin-mediated cell-cell adhesion prevents invasiveness on human carcinoma cells. J. Cell Biol., 113, 173-185 (1991).
7. GABBERT, H.E., Mechanisms in tumor invasion: evidence from in vivo observations. Cancer Metastasis Rev., 4, 293-309 (1985).
8. GABBERT, H.E., MEIER, S., GERHARZ, C.D. and HOMMEL, G., Incidence and prognostic significance of vascular invasion in 529 gastric cancer patients. Int. J. Cancer, 49, 203-207 (1991).
9. GABBERT, H.E., MEIER, S., GERHARZ, C.D. and HOMMEL, G., Tumor-cell dissociation at the invasion front: a new prognostic parameter in gastric cancer patients. Int. J. Cancer, 50, 202-207 (1992).
10. 2+ ion medium. J. Cell Biol., 113, 881-892 (1991).
11. KATAGIRI, A., WATANABE, R. and TOMITA, Y., E-cadherin expression in renal cell cancer and its significance in metastasis and survival. Brit. J. Cancer, 71, 376-379 (1995).
12. LIPPONEN, P., SAARELAINEN, E., JI, H., AALTOMAA, S. and SYRJÄNEN, K., Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer. J. Pathol., 174, 101-109 (1994).
13. MAREEL, M., BEHRENS, J., BIRCHMEIER, W., DE BRUYNE, G., VLEMINCKX, K., HOOGEWIJS, A., FIERS, W. and VAN ROY, F., Down regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int. J. Cancer, 47, 922-928 (1991).
14. MAREEL, M., BRACKE, M. and VAN ROY, F., Invasion promotor versus invasion suppressor molecules: the paradigm of E-cadherin. Mol. Biol. Rep., 19, 45-67 (1994).
15. MATSUI, S., SHIOZAKI, H., INOUE, M., TAMURA, S., DOKI, Y., KADOWAKI, T., IWAZAWA, T., SHIMAYA, K., NAGAFUCHI, A., TSUKITA, S. and MORI, T., Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchow. Arch., 424, 375-381 (1994).
16. MATSUURA, K., KAWANISHI, I., FUJII, S., IMAMURA, M., HIRANO, S., TAKEICHI, M. and NIITSU, Y., Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid. Brit. J. Cancer, 66, 1122-1130 (1992).
17. MATSUYOSHI, N., HAMAGUCHI, M., TANIGUCHI, S., NAGAFUCHI, A., TSUKITA, S. and TAKEICHI, M., Cadherin-mediated cell-cell adhesion is perturbed by V-src tyrosine phosphorylation in metastatic fibroblasts. J. Cell Biol., 118, 703-714 (1992).
18. MATTIJSSEN, V., PETERS, H.M., SCHALKWUK, L., MANNI, J.J., VAN'T HOF-GROOTENBOER, B., DE MULDER, P.H.M. and RUITER, D.J., E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. Int. J. Cancer, 55, 580-585 (1993).
19. MAYER, B., JOHNSON, J.P., LEITL, F., JAUCH, K.W., HEISS, M.M., SCHILDBERG, F.W., BIRCHMEIER, W. and FUNKE, J., E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res., 53, 1690-1695 (1993).
20. MOLL, R., MITZE, M., FRIXEN, U.W. and BIRCHMEIER, W., Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Amer. J. Pathol., 143, 1731-1742 (1993).
21. NAGAFUCHI, A. and TAKEICHI, M., Transmembrane control of E-cadherin-mediated cell adhesion in a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin. Cell Regul, 1, 37-44 (1989).
22. OKA, H., SHIOZAKI, H., KOBAYASHI, K., TAMARA, H., TAMURA, S., MIYATA, M., DOKl, Y., IIHARA, K., MATSUYOSHI, N., HIRANO, S., TAKEICHI, M. and MORI, T., Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer. Virchow. Arch. A (Pathol. Anat), 421, 149-156 (1992).
23. OOTA, K. and SOBIN, L.H., Histological typing of gastric and esophageal tumors. International histologic classification of tumors, 18, World Health Organization, Geneva (1990).
24. 2+ binding site of uvomorulin abolish the adhesive function. Cell, 63, 1033-1038 (1990a).
25. OZAWA, M., RINGWALD, M. and KEMLER, R., Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. nat. Acad. Sci. (Wash.), 87, 4246-4250 (1990b).
26. SHIMOYAMA, Y. and HIROHASHI, S., Expression of E- and P-cadherin in gastric carcinomas. Cancer Res., 51, 2185-2192 (1991).
27. SHIMOYAMA, Y., NAGAFUCHI, A., FUJITA, S., GOTOH, M., TAKEICHI, M., TSUKITA, S. and HIROHASHI, S., Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness. Cancer Res., 52, 5770-5774 (1992).
28. SHIOZAKI, H., IIHARA, K., OKA, H., KADOWAKI, T., MATSUI, S., GOFUKU, J., INOUE, M., NAGAFUCHI, A., TSUKITA, S. and MORI, T., Immunohistochemical detection of α-catenin expression in human cancers. Amer. J. Pathol., 144, 667-674 (1994).
29. SHIOZAKI, H., TAHARA, H., OKA, H., MIYATA, M., KOBAYASHI, K., TAMURA, S., IIHARA, K., DOKI, Y., HIRANO, S., TAKEICHI, M. and MORI, T., Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Amer. J. Pathol., 139, 17-23 (1991).
30. TAKEICHI, M., Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, 1451-1455 (1991).
31. UICC, TNM classification of malignant tumors (4th ed.), pp. 43-46, Springer-Verlag, Berlin (1992).
32. VAN DER WURFF, A.A.M., KATE, J.T., VAN DER LINDEN, E.P.M., DINJENS, W.N.M., ARENDS, J.-W. and BOSMAN, F.T., L-CAM expression in normal, premalignant and malignant colon mucosa. J. Pathol., 168, 287-291 (1992).
33. VLEMINCKX, K., VAKAET, L., MAREEL, M., FIERS, W. and VAN ROY, F., Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66, 107-119 (1991).
34. WEIDNER, K.M., BEHRENS, J., VANDEKERCKHOVE, J. and BIRCHMEIER, W., Scatter factor: molecular characteristics and effect on the invasion of epithelial cells. J. Cell Biol., 111, 2097-2108 (1990).
35. YONEMURA, Y., NOJIMA, N., KAJI, M., FUJIMURA, T., HOH, H., NINOMIYA, J., MIYAZAKI, I., ENDO, Y. and SASAKI, T., E-cadherin and urokinase-type plasminogen activator tissue status in gastric carcinoma. Cancer, 76, 941-953 (1995).