Role for raphe magnus neuronal responses in the behavioral reactions to colorectal distension

Journal of Neurophysiology

Volumn 92, Issue 4, 2004, Pages 2302-2311

  Brink, Thaddeus S ^a   Mason, Peggy ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BEHAVIOR; BODY MOVEMENT; BRAIN STEM; CARDIOVASCULAR RESPONSE; COLORECTAL DISTENSION; CONTROLLED STUDY; EVOKED RESPONSE; FLAT RESPONSE PATTERN; GRADED RESPONSE PATTERN; HUNCHING; INTESTINE DISTENSION; MAGNOCELLULAR NUCLEUS; MALE; NERVE CELL; NOCICEPTIVE STIMULATION; NONHUMAN; NONLINEAR SYSTEM; PERCEPTIVE THRESHOLD; PREDICTION; PRESSOR RESPONSE; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; SWITCH RESPONSE PATTERN; TACHYCARDIA; VISCERA; VISCEROMOTOR RESPONSE;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; COLON; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; ELECTRODES, IMPLANTED; ELECTROPHYSIOLOGY; HEART RATE; HEAT; MALE; NEURONS; PAIN; PHYSICAL STIMULATION; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECTUM; SEROTONIN;

EID: 4644284847     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00374.2004     Document Type: Article

References (45)

1. Barbaro NM, Heinricher MM, and Fields HL. Putative pain modulating neurons in the rostral ventral medulla: reflex-related activity predicts effects of morphine. Brain Res 366: 203-210, 1986.
2. Basbaum AI and Fields HL. Endogenous pain control mechanisms: review and hypothesis. Ann Neurol 4: 451-462, 1978.
3. Basbaum AI and Fields HL. The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J Comp Neurol 187: 513-531, 1979.
4. Brink TS and Mason P. Raphe magnus neurons respond to noxious colorectal stimulation. J Neurophysiol 89: 2506-2515, 2003.
5. Chandler MJ, Qin C, Zhang J, and Foreman RD. Differential effects of urinary bladder distension on high cervical projection neurons in primates. Brain Res 949: 97-104, 2002.
6. Cheng ZF, Fields HL, and Heinricher MM. Morphine microinjected into the periaqueductal gray has differential effects on three classes of medullary neurons. Brain Res 375: 57-65, 1986.
7. Ellrich J, Ulucan C, and Schnell C. Are "neutral cells" in the rostral ventro-medial medulla subtypes of on and off cells? Neurosci Res 38: 419-423, 2000.
8. Fields HL, Bry J, Hentall I, and Zorman G. The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J Neurosci 3: 2545-2552, 1983a.
9. Fields HL, Heinricher MM, and Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci 14; 219-245, 1991.
10. Fields HL, Vanegas H, Hentall ID, and Zorman G. Evidence that disinhibition of brain stem neurons contributes to morphine analgesia. Nature 306: 684-686, 1983b.
11. Gebhart GF and Sengupta JN. Evaluation of visceral pain. In: Handbook of Methods in Gastrointestinal Pharmacology, edited by Gaginella TS. Boca Raton, FL: CRC, 1996, p. 359-373.
12. Heinricher MM and Drasner K. Lumbar intrathecal morphine alters activity of putative nociceptive modulatory neurons in rostral ventromedial medulla. Brain Res 549: 338-341, 1991.
13. Heinricher MM, Morgan MM, and Fields HL. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience 48: 533-543, 1992.
14. Heinricher MM, Morgan MM, Tortorici V, and Fields HL. Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience 63: 279-288, 1994.
15. Holstege G and Kuypers HG. The anatomy of brain stem pathways to the spinal cord in cat. A labeled amino acid tracing study. Prog Brain Res 57: 145-175, 1982.
16. Holt IL, Akeyson EW, and Knuepfer MM. Medial medullary contribution to tonic descending inhibition of visceral input. Am J Physiol Regulatory Integrative Comp Physiol 261: R727-737, 1991.
17. Janss AJ and Gebhart GF. Brainstem and spinal pathways mediating descending inhibition from the medullary lateral reticular nucleus in the rat. Brain Res 440; 109-122, 1988.
18. Knuepfer MM and Holt IL. Effects of electrical and chemical stimulation of nucleus raphe magnus on responses to renal nerve stimulation. Brain Res 543: 327-334, 1991.
19. Leung CG and Mason P. A physiological survey of medullary raphe and magnocellular reticular neurons in the anesthetized rat. J Neurophysiol 80: 1630-1646, 1998.
20. Li YW and Bayliss DA. Presynaptic inhibition by 5-HT1B receptors of glutamatergic synaptic inputs onto serotonergic caudal raphe neurons in rat. J Physiol 510: 121-134, 1998.
21. Liu RH, Tang JS, and Hou ZL. Electrophysiological identification of spinally projecting neurons in the lateral reticular nucleus of the rat. Brain Res 481: 350-355, 1989.
22. Mason P. Physiological identification of pontomedullary serotonergic neurons in the rat. J Neurophysiol 77: 1087-1098, 1997.
23. Mason P. Contributions of the medullary raphe and ventromedial reticular region to pain modulation and other homeostatic functions. Annu Rev Neurosci 25: 737-777, 2001.
24. Ness TJ. Evidence for ascending visceral nociceptive information in the dorsal midline and lateral spinal cord. Pain 87: 83-88, 2000.
25. Ness TJ, Follett KA, Piper J, and Dirks BA. Characterization of neurons in the area of the medullary lateral reticular nucleus responsive to noxious visceral and cutaneous stimuli. Brain Res 802: 163-174, 1998.
26. Ness TJ and Gebhart GF. Characterization of neuronal responses to noxious visceral and somatic stimuli in the medial lumbosacral spinal cord of the rat. J Neurophysiol 57: 1867-1892, 1987.
27. 2 spinal cord of the rat. J Neurophysiol 60: 1419-1438, 1988a.
28. Ness TJ and Gebhart GF. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Res 450: 153-169, 1988b.
29. 2 dorsal horn neurons encoding for colorectal distension in the rat: comparison with neurons in deep laminae. Brain Res 486: 301-309, 1989.
30. Newman DB. Distinguishing rat brainstem reticulospinal nuclei by their neuronal morphology. I. Medullary nuclei. J Hirnforsch 26: 187-226, 1985.
31. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego: Academic, 1986.
32. Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Jr, Ossipov MH, Lappi DA, and Lai J. Inhibition of neuropathic pain by selective ablation of brain stem medullary cells expressing the micro-opioid receptor. J Neurosci 21: 5281-5288, 2001.
33. Porreca F, Ossipov MH, and Gebhart GF. Chronic pain and medullary descending facilitation. Trends Neurosci 25: 319-325, 2002.
34. Qin C, Chandler MJ, Jou CJ, and Foreman RD. Responses and afferent pathways of c1-c2 spinal neurons to cervical and thoracic esophageal stimulation in rats. J Neurophysiol 91: 2227-2235, 2004.
35. Qin C, Chandler MJ, Miller KE, and Foreman RD. Chemical activation of cervical cell bodies: effects on responses to colorectal distension in lumbosacral spinal cord of rats. J Neurophysiol 82: 3423-3433, 1999.
36. Sandkuhler J. The organization and function of endogenous antinociceptive systems. Prog Neurobiol 50: 49-81, 1996.
37. Sengupta JN and Gebhart GF. Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 71: 2046-2060, 1994.
38. Strigo IA, Bushnell MC, Boivin M, and Duncan GH. Psychophysical analysis of visceral and cutaneous pain in human subjects. Pain 97: 235-246, 2002.
39. Su X and Gebhart GF. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol 80: 2632-2644, 1998.
40. Su X, Sengupta JN, and Gebhart GF. Effects of kappa opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension. J Neurophysiol 78: 1003-1012, 1997.
41. Traub RJ, Pechman P, Iadarola MJ, and Gebhart GF. Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat. Pain 49: 393-403, 1992.
42. Wang W, Tiwari JK, Bradley SR, Zaykin RV, and Richerson GB. Acidosis-stimulated neurons of the medullary raphe are serotonergic. J Neurophysiol 85: 2224-2235, 2001.
43. Zhang X, Jiang C, Tan Z, and Fogel R. Vagal motor neurons in rats respond to noxious and physiological gastrointestinal distention differentially. Eur J Neurosci 16: 2027-2038, 2002.
44. Zhuo M and Gebhart GF. Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat. Gastroenterology 122: 1007-1019, 2002.
45. Zhuo M, Sengupta JN, and Gebhart GF. Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat. J Neurophysiol 87: 2225-2236, 2002.