Physiological identification of pontomedullary serotonergic neurons in the rat

Journal of Neurophysiology

Volumn 77, Issue 3, 1997, Pages 1087-1098

  Mason, Peggy ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CELLULAR DISTRIBUTION; GIGANTOCELLULAR RETICULAR NUCLEUS; LATERAL RETICULAR NUCLEUS; MALE; NONHUMAN; PONS; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAPHE NUCLEUS; RAT; SEROTONINERGIC NERVE CELL; SPINAL CORD NERVE CELL; TISSUE DISTRIBUTION;

EID: 0031004813     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.3.1087     Document Type: Article

References (56)

1. AGHAJANIAN, G. K., FOOTE, W. E., AND SHEARD, M. H. Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe. Science Wash. DC 161: 706-708, 1968.
2. AGHAJANIAN, G. K. AND VANDERMAELEN, C. P. Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure. J. Neurosci. 2: 1786-1792, 1982.
3. ASTON-JONES, G. AND BLOOM, F. E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J. Neurosci. 1: 876-886, 1981.
4. AUERBACH, S., FORNAL, C., AND JACOBS, B. L. Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats. Exp. Neurol. 88: 609-628, 1985.
5. BASBAUM, A. I. AND FIELDS, H. L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 7: 309-338, 1984.
6. BELCHER, G., RYALL, R. W., AND SCHAFFNER, R. The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat. Brain Res. 151: 307-321, 1978.
7. BOWKER, R. M. AND ABHOLD, R. H. Evoked changes in 5-hydroxytryptamine and norepinephrine release: in vivo dialysis of the rat dorsal horn. Eur. J. Pharmacol. 175: 101-106, 1990.
8. BOWKER, R. M., WESTLUND, K. N., SULLIVAN, M. C., WILBER, J. F., AND COULTER, J. D. Descending serotonergic, peptidergic and cholinergic pathways from the raphe nuclei: a multiple transmitter complex. Brain Res. 288: 33-48, 1983.
9. CHIANG, C. Y. AND GAO, B. The modification by systemic morphine of the responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to heating the tail. Pain 26: 245-257, 1986.
10. CRILL, W. E. Unitary multiple-spiked responses in cat inferior olive nucleus. J. Neurophysiol. 33: 199-209, 1970.
11. DAHLSTROM, A. AND FUXE, K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamine in the cell bodies of brain stem neurons. Acta Physiol. Scand. Suppl. 232: 1-36, 1964.
12. DUGGAN, A. W. Neuropharmacology of pain. Curr. Opin. Neurol. Neurosurg. 5: 503-507, 1992.
13. ESCOBEDO, I. AND MASON, P. Nociceptive responsiveness is greater during slow wave sleep than during waking. Soc. Neurosci. Abstr. 21: 387, 1995.
14. FIELDS, H. L., BRY, J., HENTALL, I., AND ZORMAN, G. The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J. Neurosci. 3: 2545-2552, 1983.
15. FIELDS, H. L., HEINRICHER, M. M., AND MASON, P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14: 219-245, 1991.
16. FORNAL, C., AUERBACH, S., AND JACOBS, B. L. Activity of serotonin-containing neurons in nucleus raphe magnus in freely moving cats. Exp. Neurol. 88: 590-608, 1985.
17. FORNAL, C. A., LITTO, W. J., MORILAK, D. A., AND JACOBS, B. L. Single-unit responses of serotonergic neurons to vasoactive drug administration in behaving cats. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28)R963-R972, 1990.
18. FURSHPAN, E. J. AND FURAKAWA, T. Intracellular and extracellular responses in the several regions of the mauthner cell of the goldfish. J. Physiol. Lond. 732-771, 1962.
19. FUXE, K. Evidence for the existence of monoamine-containing neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the CNS. Acta Physiol. Scand. Suppl. 247: 37-80, 1965.
20. HAMMOND, D. L., TYCE, G. M., AND YAKSH, T. L. Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J. Physiol. Lond. 359: 151-162, 1985.
21. HEYM, J., STEINFELS, G. F., AND JACOBS, B. L. Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD. Eur. J. Pharmacol. 81: 677-680, 1982a.
22. HEYM, J., STEINFELS, G. F., AND JACOBS, B. L. Chloral hydrate anesthesia alters the responsiveness of central serotonergic neurons in the cat. Brain Res. 291: 63-72, 1984.
23. HEYM, J., TRULSON, M. E., AND JACOBS, B. L. Raphe unit activity in freely moving cats: effects of phasic auditory and visual stimuli. Brain Res. 232: 29-39, 1982b.
24. JACOBS, B. L. AND AZMITIA, E. C. Structure and function of the brain serotonin system. Physiol. Rev. 72: 165-229, 1992.
25. JONES, B. E. Reticular formation: cytoarchitecture, transmitters, and projections. In: The Rat Nervous System, edited by G. Paxinos. San Diego, CA: Academic, 1995, p. 155-171.
26. JONES, B. E., HOLMES, C. J., RODRIGUEZ, V. E., AND MAINVILLE, L. GABA-synthesizing neurons in the medulla: their relationship to serotonin-containing and spinally projecting neurons in the rat. J. Comp. Neurol. 313: 349-367, 1991.
27. KLEITMAN, N. Sleep and Wakefulness. Chicago, IIUniv. of Chicago Press, 1963.
28. KRUGER, L., SAPORTA, S., AND SWANSON, L. W. Photographic Atlas of the Rat Brain. New YorkCambridge Univ. Press, 1995.
29. KWIAT, G. C. AND BASBAUM, A. I. The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat. Somatosens. Mot. Res. 9: 157-173, 1992.
30. LACHENBRUCH, P. A. AND MICKEY, M. A. Estimation of error rates in discriminant analysis. Technometrics 10: 1-10, 1968.
31. LEBARS, D. Serotonin and pain. InNeuronal Serotonin, edited by N. N. Osborne and M. Hamon, New York: Wiley, 1988, p. 171-226.
32. LEUNG, C. G. AND MASON, P. Effects of anesthetic depth on the activity of pontomedullary raphe and medial reticular neurons in the rat. Brain Res. 699: 71-82, 1995.
33. MCCALL, R. B. AND CLEMENT, M. E. Identification of serotonergic and sympathetic neurons in medullary raphe nuclei. Brain Res. 477: 172-182, 1989.
34. MONTI, J. M. Involvement of histamine in the control of the waking state. Life Sci. 53: 1331-1338, 1993.
35. MOORE, R. Y. The anatomy of central serotonin neuron systems in the rat brain. InSerotonin Neurotransmission and Behavior, edited by B. L. Jacobs and A. Gelperin. Boston, MA: MIT Press, 1981, p. 35-71.
36. MOORE, R. Y. AND BLOOM, F. E. Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Annu. Rev. Neurosci. 2: 113-168, 1979.
37. MORRISON, D. F. Multivariate Statistical Methods. New YorkMcGraw-Hill, 1990.
38. NEWMAN, D. B. Distinguishing rat brainstem reticulospinal nuclei by their neuronal morphology. I. Medullary nuclei. J. Hirnforsch. 26: 187-226, 1985a.
39. NEWMAN, D. B. Distinguishing rat brainstem reticulospinal nuclei by their neuronal morphology. II. Pontine and mesencephalic nuclei. J. Hirnforsch. 26: 385-418, 1985b.
40. OLIVERAS, J. L., BOURGOIN, S., HERY, F., BESSON, J. M., AND HAMON, M. The topographical distribution of serotoninergic terminals in the spinal cord of the cat: biochemical mapping by the combined use of microdissection and microassay procedures. Brain Res. 138: 393-406, 1977.
41. PAXINOS, G. AND WATSON, C. The Rat Brain In Stereotaxic Coordinates. San Diego, CAAcademic, 1986.
42. POTREBIC, S. B., FIELDS, H. L., AND MASON, P. Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla. J. Neurosci. 14: 1655-1665, 1994.
43. POTREBIC, S. B., MASON, P., AND FIELDS, H. L. The density and distribution of serotonergic appositions onto identified neurons in the rostral ventromedial medulla. J. Neurosci. 15: 3273-3283, 1995.
44. RAMIREZ, F. AND VANEGAS, H. Tooth pulp stimulation advances both medullary off-cell pause and tail flick. Neurosci. Lett. 100: 153-156, 1989.
45. SAITO, Y., COLLINS, J. G., AND IWASAKI, H. Tonic 5-HT modulation of spinal dorsal horn neuron activity evoked by both noxious and non-noxious stimuli: a source of neuronal plasticity. Pain 40: 205-219, 1990.
46. SAWYNOK, J. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Can. J. Physiol. Pharmacol. 67: 975-988, 1989.
47. SAWYNOK, J. AND REID, A. Effect of 6-hydroxydopamine-induced lesions to ascending and descending noradrenergic pathways on morphine analgesia. Brain Res. 419: 156-165, 1987.
48. SORKIN, L. S., MCADOO, D. J., AND WILLIS, W. D. Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn. Brain Res. 618: 95-108, 1993.
49. STEIN, R. B. Some models of neuronal variability. Biophys. J. 7: 37-68, 1967.
50. STEINBUSCH, H. W., NIEUWENHUYS, R., VERHOFSTAD, A. A., AND VAN DER KOOY, D. The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study. J. Physiol. Lond. 77: 157-174, 1981.
51. TABER, E., BRODAL, A., AND WALBERG, F. The raphe nuclei of the brain stem of the cat. I. Normal topography and cytoarchitechture and general discussion. J. Comp. Neurol. 114: 161-187, 1960.
52. WESSENDORF, M. W. AND ANDERSON, E. G. Single unit studies of identified bulbospinal serotonergic units. Brain Res. 279: 93-103, 1983.
53. WESSENDORF, M. W., PROUDFIT, H. K., AND ANDERSON, E. G. The identification of serotonergic neurons in the nucleus raphe magnus by conduction velocity. Brain Res. 214: 168-173, 1981.
54. WILBUR, W. J. AND RINZEL, J. A theoretical basis for large coefficient of variation and bimodality in neuronal interspike interval distributions. J. Theor. Biol. 105: 345-368, 1983.
55. YAKSH, T. L. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav. 22: 845-858, 1985.
56. YAKSH, T. L. AND WILSON, P. R. Spinal serotonin terminal system mediates antinociception. J. Pharmacol. Exp. Ther. 208: 446-453, 1979.