Second case of CML with aberrant BCR-ABL fusion transcript (e8/a2) with insertion of an inverted ABL intron 1b sequence

American Journal of Hematology

Volumn 77, Issue 2, 2004, Pages 164-166

  Sugimoto, Takeshi ^a,b   Ijima, Kentaro ^c   Hisatomi, Hisashi ^c   Murayama, Tohru ^a   Mizuno, Ishikazu ^a   Hato, Akio ^a   Imoto, Shion ^a   Nishimura, Ryuichiro ^a   Koizumi, Tamio ^a  

^a HYOGO MEDICAL CENTER FOR ADULTS   (Japan)

^b Kobe Kyodo Hospital   (Japan)

^c SRL INC   (Japan)

Author keywords

BCR ABL; CML; Philadelphia chromosome; RT PCR

Indexed keywords

AGED; ARTICLE; BCR ABL GENE; CASE REPORT; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; EXON; FEMALE; GENE; GENE FUSION; GENE INSERTION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; INTRON 1B SEQUENCE; NUCLEOTIDE SEQUENCE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

AGED; EXONS; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; INTRONS; INVERSION, CHROMOSOME; LEUKEMIA, MYELOID, CHRONIC; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION, GENETIC;

EID: 4644278994     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20138     Document Type: Article

References (12)

1. Saglio G, Guerrasio A, Rosso C, et al. New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 1990;76:1819-1824.
2. Hochhaus A, Reiter A, Skladny H, et al. A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia. Blood 1996;88:2236-2240.
3. Okamoto K, Karasawa M, Sakai H, Ogura H, Morita K, Naruse T. A novel acute lymphoid leukaemia-type BCR/ABL transcript in chronic myelogenous leukaemia. Br J Haematol 1997;96:611-613.
4. Rubinstein R, Purves LR. A novel BCR-ABL rearrangement in a Philadelphia chromosome-positive chronic myelogenous leukaemia variant with thrombocythaemia. Leukemia 1998;12:230-232.
5. Byrne JL, Carter GI, Davies JM, Haynes AP, Russell NH, Cross NC. A novel BCR-ABL fusion gene (e2/1a) in a patient with Philadelphia-positive chronic myelogenous leukaemia and an aggressive clinical course. Br J Haematol 1998;103:791-794.
6. Leibundgut EO, Jotterand M, Rigamonti V, et al. A novel BCR-ABL transcript e2a2 in a chronic myelogenous leukaemia patient with a duplicated Ph-chromosome and monosomy 7. Br J Haematol 1999;106:1041-1044.
7. How GF, Lim LC, Kulkarni S, Tan LT, Tan P, Cross NC. Two patients with novel BCR/ABL fusion transcripts (e8/a2 and e13/a2) resulting from translocation breakpoints within BCR exons. Br J Haematol 1999;105:434-436.
8. Martinelli G, Terragna C, Amabile M, et al. Translisin recognition site sequences flank translocation breakpoints in a Philadelphia chromosome positive chronic myeloid leukemia patient expressing a novel type of chimeric BCR-ABL transcript (E8-INT-A2). Leukemia 1999;13:1635-1637.
9. Roman J, Parziale A, Gottardi E, et al. Novel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantation. Br J Haematol 2000;111: 644-646.
10. Branford S, Rudzki Z, Hughes TP. A novel BCR-ABL transcript (e8a2) with the insertion of an inverted sequence of ABL intron 1b in a patient with Philadelphia-positive chronic myeloid leukaemia. Br J Haematol 2000;109:635-637.
11. Shiratsuchi M, Muta K, Minami R, et al. Aberrant BCR-ABL transcript with intronic insertion in a patient with Philadelphia chromosome-positive chronic myeloid leukemia: implications for disease progression. Leuk Lymphoma 2001;41:411-415.
12. Moreno M del P, Cortinas MN, Bonomi R, Cardeza A, Uriarte M del R. A novel BCR-ABL fusion transcript (e15a2) in 2 patients with atypical chronic myeloproliferative syndrome. Blood 2001;97: 3668-3669.