A novel BCR-ABL transcript e2a2 in a chronic myelogenous leukaemia patient with a duplicated Ph-chromosome and monosomy 7

British Journal of Haematology

Volumn 106, Issue 4, 1999, Pages 1041-1044

  Leibundgut, Elisabeth Oppliger ^a   Jotterand, Martine ^b   Rigamonti, Veronique ^a   Parlier, Valérie ^b   Mühlematter, Dominique ^b   Tobler, Andreas ^a   Solenthaler, Max ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

BCR ABL; Chronic myelogenous leukaemia; Monosomy 7; Philadelphia chromosome; RT PCR

Indexed keywords

AGED; ARTICLE; CASE REPORT; CHROMOSOME 22Q; CHROMOSOME 9Q; CHROMOSOME BANDING PATTERN; CHROMOSOME DUPLICATION; CHRONIC MYELOID LEUKEMIA; FEMALE; HUMAN; MONOSOMY 7; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 7; FATAL OUTCOME; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MONOSOMY; TRANSLOCATION, GENETIC;

EID: 0032827231     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01640.x     Document Type: Article

References (12)

1. Byrne, J.L., Carter, G.I., Davies, J.M., Haynes, A.P., Russell, N.H. & Cross, N.C. (1998) A novel BCR-ABL fusion gene (e2/1a) in a patient with Philadelphia-positive chronic myelogenous leukaemia and an aggressive clinical course. British Journal of Haematology, 103, 791-794.
2. Castagne, C., Mühlematter, D., Martinet, D. & Jotterand, M. (1999) Effect of conditioned medium, nutritive elements, and mitotic synchronization on the accuracy of the cytogenetic analysis in patients with chronic myeloid leukemia at diagnosis and during alpha-interferon therapy. Cancer Genetics and Cytogenetics, 109, 166-171.
3. Cross, N.C.P., Melo, J.V., Feng, L. & Goldman, J.M. (1994) An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in hematological disorders. Leukemia, 8, 186-189.
4. Dhingra, K., Talpaz, M., Kantarjian, H., Ku, S., Rothberg, J., Gutterman, J.U. & Kurzrock, R, (1991) Appearance of acute leukemia-associated P190BCR-ABL in chronic myclogenous leukemia may correlate with disease progression. Leukemia, 5, 191-195.
5. Gonzalez Garcia, J.R., Garces Ruiz, O.M., Delgado Lamas, J.L. & Ramirez-Duenas, M.I. (1997) Two different Philadelphia chromosomes in a cell line from an AML-MO patient. Cancer Genetics and Cytogenetics, 98, 111-114.
6. Hochhaus, A., Reiter, A., Skladny, H., Melo, J.V., Sick, C., Berger, U., Guo, J.Q., Arlinghaus. R.B., Hehlmann, R., Goldman, J.M. & Cross, N.C. (1996) A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia. Blood, 88, 2236-2240.
7. Maddox, A.M., Keating, M.J., Trujillo, J., Cork. A., Youness, E., Ahearn, M.J., McCredie, K.B, & Freireich, E.J. (1983) Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: a subgroup with poor response to therapy. Leukemia Research, 7, 509-522.
8. Melo, J.V (1996) The molecular biology of chronic myeloid leukemia, Leukemia, 10, 751-756.
9. Mitelman, F. (1993) The cytogenetic scenario of chronic myeloid leukemia, Leukemia and Lymphoma, 11, (Suppl. 1), 11-15.
10. Okamoto, K., Karasawa, M., Sakai, H., Ogura, H., Morita, K. & Naruse, T. (1997) A novel acute lymphoid Leukaemia type BCR/ABL transcript in chronic myelogenous leukaemia. British Journal of Haematology, 96, 611-613.
11. Saglio, G., Pane, F., Martinelli, G. & Guerrasio, A, (1997) BCR/ABL transcripts und leukemia phenotype: an unsolved puzzle. Leukemia and Lymphoma, 26, 281-286.
12. Seghezzi, L., Dellavecchia, C., Maserati. E., Minelli, A., Carra, A., Locatelli, F., Argusti, A., Lo Curto, F., Danesino, C, & Pasquali, F. (1997) Ph-positive CML in blastic phase with monosomy 7 in a Down syndrome patient: monitoring by interphase cytogenetics and demonstration of maternal allelic loss. Cancer Genetics and Cytogenetics, 99, 77-80.