Breast cancer in female carriers of ATM gene alterations: Outcome of adjuvant radiotherapy

Radiotherapy and Oncology

Volumn 72, Issue 3, 2004, Pages 319-323

  Meyer, Andreas ^a   John, Esther ^a   Dörk, Thilo ^a   Sohn, Christof ^a   Karstens, Johann H ^a   Bremer, Michael ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Adjuvant radiotherapy; AT heterozygosity; Breast cancer; Treatment outcome

Indexed keywords

ATM PROTEIN;

ADULT; AGED; BREAST CANCER; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CONFERENCE PAPER; DATA ANALYSIS; FEMALE; FOLLOW UP; GENE CONTROL; GENE MUTATION; GENETIC VARIABILITY; GENOME; HETEROZYGOTE DETECTION; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; METASTASIS; MISSENSE MUTATION; POSTOPERATIVE CARE; PRIORITY JOURNAL; RECURRENCE RISK; REGRESSION ANALYSIS;

ADULT; AGED; BREAST NEOPLASMS; CELL CYCLE PROTEINS; DISEASE-FREE SURVIVAL; DNA-BINDING PROTEINS; FEMALE; FOLLOW-UP STUDIES; HETEROZYGOTE; HUMANS; MIDDLE AGED; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RADIOTHERAPY, ADJUVANT; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEINS;

EID: 4644258760     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.07.010     Document Type: Conference Paper

References (21)

1. M. Bremer, K. Klopper, P. Yamini, R. Bendix-Waltes, T. Dork, and J.H. Karstens Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects Radiother Oncol 69 2003 155 160
2. A. Broeks, J.H. Urbanus, and P. de Knijff IVS10-6T>G, an ancient ATM germline mutation linked with breast cancer Hum Mutat 21 2003 521 528
3. T.A. Buchholz, M.M. Weil, and C.L. Ashorn A Ser49Cys variant in the ataxia telangiectasia mutated gene that is more common in patients with breast carcinoma compared with population controls Cancer 100 2004 1345 1351
4. G. Chenevix-Trench, A.B. Spurdle, and M. Gatei Dominant negative ATM mutations in breast cancer families J Natl Cancer Inst 94 2002 205 215
5. T. Dork, R. Bendix, and M. Bremer Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients Cancer Res 61 2001 7608 7615
6. S. Gutierrez-Enriquez, M. Fernet, and T. Dork Functional consequences of ATM sequence variants for chromosomal radiosensitivity Genes Chromosomes Cancer 40 2004 109 119
7. M.B. Kastan, D.S. Lim, S.T. Kim, and D. Yang ATM - a key determinant of multiple cellular responses to irradiation Acta Oncol 40 2001 686 688
8. K.K. Khanna, M.F. Lavin, S.P. Jackson, and T.D. Mulhern ATM, a central controller of cellular responses to DNA damage Cell Death Differ 8 2001 1052 1065
9. G.P. Larson, G. Zhang, and S. Ding An allelic variant at the ATM locus is implicated in breast cancer susceptibility Genet Test 1 1997 165 170
10. M.F. Lavin, and Y. Shiloh The genetic defect in ataxia-telangiectasia Annu Rev Immunol 15 1997 177 202
11. S. Neubauer, R. Arutyunyan, and M. Stumm Radiosensitivity of ataxia telangiectasia and Nijmegen breakage syndrome homozygotes and heterozygotes as determined by three-color FISH chromosome painting Radiat Res 157 2002 312 321
12. N. Sandoval, M. Platzer, and A. Rosenthal Characterization of ATM gene mutations in 66 ataxia telangiectasia families Hum Mol Genet 8 1999 69 79
13. S.P. Scott, R. Bendix, P. Chen, R. Clark, T. Dork, and M.F. Lavin Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer Proc Natl Acad Sci USA 99 2002 925 930
14. Y. Shiloh ATM and related protein kinases: safeguarding genome integrity Nat Rev Cancer 3 2003 155 168
15. T. Stankovic, A.M. Kidd, and A. Sutcliffe ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer Am J Hum Genet 62 1998 334 345
16. Y. Su, and M. Swift Mortality rates among carriers of ataxia-telangiectasia mutant alleles Ann Intern Med 133 2000 770 778
17. Y. Su, and M. Swift Outcomes of adjuvant radiation therapy for breast cancer in women with ataxia-telangiectasia mutations J Am Med Assoc 286 2001 2233 2234
18. M. Swift, D. Morrell, R.B. Massey, and C.L. Chase Incidence of cancer in 161 families affected by ataxia-telangiectasia N Engl J Med 325 1991 1831 1836
19. S.N. Teraoka, K.E. Malone, and D.R. Doody Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history Cancer 92 2001 479 487
20. Y.R. Thorstenson, A. Roxas, and R. Kroiss Contributions of ATM mutations to familial breast and ovarian cancer Cancer Res 63 2003 3325 3333
21. J.B. Weissberg, D.D. Huang, and M. Swift Radiosensitivity of normal tissues in ataxia-telangiectasia heterozygotes Int J Radiat Oncol Biol Phys 42 1998 1133 1136