Synthesis and anti-tubercular activity of a series of 2-sulfonamido/ trifluoromethyl-6-substituted imidazo[2,1-b]-1,3,4-thiadiazole derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 21, 2004, Pages 5651-5659

  Gadad, Andanappa K ^a   Noolvi, Malleshappa N ^a   Karpoormath, Rajshekhar V ^a  

^a B

Author keywords

Haloaryl heteroaryl ketones; Anti tubercular activity; BACTEC assay; Imidazo 2,1 b 1,3,4 thiadiazoles

Indexed keywords

2 SULFONAMIDO 5 BROMO 6 (3',4',5' TRIMETHOXYPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 SULFONAMIDO 5 THIOCYANATO 6 (4' CHLOROPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 SULFONAMIDO 5 THIOCYANATO 6 (4' METHYLPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 SULFONAMIDO 6 (3',4',5' TRIMETHOXYPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 SULFONAMIDO 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 SULFONAMIDO 6 (4' METHOXYPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (3',4',5' TRIMETHOXYPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' BROMOPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' CHLOROPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' FLUOROPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' HYDROXYPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' METHOXYPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' METHYLPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (4' NITROPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (COUMARINYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (FUROYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; 2 TRIFLUOROMETHYL 6 (PHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; [N (DIMETHYLAMINOMETHINO)]SULFONAMIDO 5 GUANYLHYDRAZONE 6 (4' CHLOROPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; [N (DIMETHYLAMINOMETHINO)]SULFONAMIDO 5 GUANYLHYDRAZONE 6 (4' METHYLPHENYL)IMIDAZO[2,1 B] 1,3,4 THIADIAZOLE; THIADIAZOLE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; DILUTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ANTITUBERCULAR AGENTS; IMIDAZOLES; MYCOBACTERIUM TUBERCULOSIS; THIADIAZOLES;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 4644256276     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.060     Document Type: Article

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