Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake

Kidney and Blood Pressure Research

Volumn 27, Issue 4, 2004, Pages 203-210

  Vaněčková, Ivana ^a   Cahová, Monika ^a   Kramer, Herbert J ^b   Husková, Zuzana ^a   Škaroupkova, Petra ^a   Komers, Radko ^a   Bader, Michael ^c   Ganten, Detlev ^c   Červenka, Luděk ^a  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b UNIVERSITY OF BONN   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Cyclooxygenase 2; Glomerular filtration rate; Hypertension; Renal plasma flow; Renin angiotensin system; Sodium restriction

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME INHIBITION; FEMORAL ARTERY; GLOMERULUS FILTRATION RATE; HEMODYNAMIC MONITORING; HYPERTENSION; IMMUNOBLOTTING; KIDNEY; KIDNEY CLEARANCE; KIDNEY CORTEX; KIDNEY FUNCTION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM INTAKE; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD PRESSURE; CYCLOOXYGENASE INHIBITORS; DIET, SODIUM-RESTRICTED; DINOPROSTONE; GLOMERULAR FILTRATION RATE; KIDNEY CORTEX; MALE; NITROBENZENES; RATS; RENAL CIRCULATION; RENIN; RENIN-ANGIOTENSIN SYSTEM; SODIUM, DIETARY; SULFONAMIDES; THIOPHENES;

EID: 4644252170     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079865     Document Type: Article

References (34)

1. Mullins J, Peters J, Ganten D: Fulminant hypertension in transgenic rats harboring the mouse Ren-2 gene. Nature 1990;344:541-544.
2. Böhm M, Lee M, Kreutz R, Kim S, Schinke M, Djavidani B, Wagner J, Kaling M, Wienen W, Bader M, Ganten D: Angiotensin II receptor blockade in TGR(mRen2)27: Effects of reninangiotensin-system gene expression and cardiovascular functions. J Hypertens 1995;13:891-899.
3. Hirth-Dietrich C, Stasch JP, Ganten D, Luft FC: Renal effects of captopril and nitrendipine in transgenic rats with an extra renin gene. Hypertension 1994;23:626-631.
4. Gross V, Lippoldt A, Schneider W, Luft FC: Effect of captopril and angiotensin II receptor blockade on pressure natriuresis in transgenic TGR(mRen2)27 rats. Hypertension 1995;26:471-479.
5. Mitchell KD, Mullins JJ: ANG II dependence of tubuloglomerular feedback responsiveness in hypertensive ren-2 transgenic rats. Am J Physiol 1995;268(5 Pt 2):F821-F828.
6. Mitchell KD, Jacinto SM, Mullins JJ: Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 1997;273(2 Pt 2):F246-F253.
7. Jacinto SM, Mullins JJ, Mitchell KD: Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 1999;276(2 Pt 2):F315-F322.
8. Chatziantoniou C, Arendshorst WJ: Prostaglandin interactions with angiotensin, norepinephrine, and thromboxane in rat renal vasculature. Am J Physiol 1992;262(1 Pt 2):F68-F76.
9. Purdy KE, Arendshorst WJ: Prostaglandins buffer ANG II-mediated increases in cytosolic calcium in preglomerular VSMC. Am J Physiol 1999;277(6 Pt 2):F850-F858.
10. Imig JD: Eicosanoid regulation of the renal vasculature. Am J Physiol Renal Physiol 2000;279:F965-F981.
11. Harris RC: Cyclooxygenase-2 and the kidney: functional and pathophysiological implications. J Hypertens 2002;20 suppl 6:S3-S9.
12. Llinás MT, López R, Rodríguez F, Roig F, Salazar FJ: Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. Am J Physiol Renal Physiol 2001;281:F975-F982.
13. Beierwaltes WH: Cyclooxygenase-2 products compensate for inhibition of nitric oxide regulation of renal perfusion. Am J Physiol Renal Physiol 2002;283:F68-F72.
14. López R, Llinás MT, Roig F, Salazar FJ: Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine. Am J Physiol Regul Integr Comp Physiol 2003;284:R488-R493.
15. López R, Roig F, Llinás MT, Salazar FJ: Role of cyclooxygenase-2 in the control of renal haemodynamics and excretory function. Acta Physiol Scand 2003;177:429-435.
16. Pinto YM, Buikema H, Van Gilst WH, Scholtens E, Van Geel P, Wagner J, Paul M: Cardiovascular end-organ damage in Ren-2 transgenic rats compared to spontaneously hypertensive rats. J Mol Med 1997;75:371-377.
17. Jacke K, Witte K, Huser L, Behrends S, Lemmer B: Contribution of the renin-angiotensin system to subsensitivity of soluble guanylyl cyclase in TGR(mRen2)27 rats. Eur J Pharmacol 2000;403:27-35.
18. Jacke K, Witte K, Lemmer B: Mechanisms involved in the blunted nitric oxide-cGMP pathway in hypertensive TGR(mRen2)27 rats. Eur J Pharmacol 2001;415:27-30.
19. 1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats. Hypertension 1999;33:102-107.
20. Rosenstock M, Danon A, Rimon G: PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochim Biophys Acta 1999;1440:127-137.
21. Seibert K, Masferrer JL, Needleman P, Salvemini D: Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. Br J Pharmacol 1996;117:1016-1020.
22. Komers R, Lindsley JN, Oyama TT, Schutzer WE, Reed JF, Mader SL, Anderson S: Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. J Clin Invest 2001;107:889-898.
23. Ichihara A, Imig JD, Inscho EW, Navar LG: Cyclooxygenase-2 participates in tubular flowdependent afferent arteriolar tone: Interaction with neuronal NOS. Am J Physiol 1998;275(4 Pt 2):F605-F612.
24. Harding P, Carretero OA, Beierwaltes WH: Chronic cyclooxygenase-2 inhibition blunts low-sodium stimulated renin without changing renal haemodynamics. J Hypertens 2000;18:1107-1113.
25. Höcherl K, Kammerl MC, Schumacher K, Endemann D, Grobecker HF, Kurtz A: Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake. Am J Physiol Renal Physiol 2002;283:F294-F301.
26. Harris RC, McKanna JA, Akai J, Jacobson HR, Dubois RN: COX-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest 1994;94:2504-2510.
27. Červenka L, Kramer HJ, Maly J, Vaněčkova I, Bäcker A, Bokemeyer D, Bader G, Mitchell KD: Role of nNOS in regulation of renal function in hypertensive Ren-2 transgenic rats. Physiol Res 2002;52:571-580.
28. Fox J, Guan S, Hymel AA, Navar LG: Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am J Physiol 1992;262(5 Pt 2):F902-F909.
29. DiBona GF, Kopp UC: Neural control of renal function. Physiol Rev 1997;77:75-197.
30. Callahan MF, Li P, Ferrario CM, Ganten D, Morris M: Salt-sensitive hypertension in (mREN-2)27 transgenic rats. Hypertension 1996;27:573-577.
31. Barrett GL, Mullins JJ: Studies on blood pressure regulation in hypertensive ren-2 transgenic rats. Kidney Int Suppl 1992;37:S125-S128.
32. Iyer SN, Averill DB, Chappell MC, Yamada K, Allred AJ, Ferrario CM: Contribution of angiotensin-( 1-7) to blood pressure regulation in salt-depleted hypertensive rats. Hypertension 2000;36:417-422.
33. Chung O, Schips T, Rohmeiss P, Gretz N, Strauch M, Unger T: Protein excretion and renal adaptation of transgenic mRen2 rats to changing oral sodium loads. J Hypertens Suppl 1993;11 Suppl 5:S188-S189.
34. Li P, Morris M, Ferrario CM, Barrett C, Ganten D, Callahan MF: Cardiovascular, endocrine, and body fluid-electrolyte responses to salt loading in mRen-2 transgenic rats. Am J Physiol 1998;275(4 Pt 2):H1130-H1137.