Mechanism of carcinogenesis in familial tumors

International Journal of Clinical Oncology

Volumn 9, Issue 4, 2004, Pages 232-245

  Tamura, Kazuo ^a   Utsunomiya, Joji ^a,b,c   Iwama, Takeo ^a,d   Furuyama, Jun Ichi ^e   Takagawa, Tetsuya ^a   Takeda, Naohisa ^a   Fukuda, Yoshihiro ^a   Matsumoto, Takayuki ^a   Nishigami, Takashi ^a   Kusuhara, Kiyoshi ^f   Sagayama, Ken ^a   Nakagawa, Kazuhiko ^a   Yamamura, Takehira ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

^c Junshin Familial Tumor Institute   (Japan)

^d SASAKI INSTITUTE   (Japan)

^e Kansai Nursing School   (Japan)

^f Hanwa Sumiyoshi General Hospital   (Japan)

Author keywords

Familial tumor; Genotype phenotype correlation; Microsatellite instability; Multistep carcinogenesis; Two hit theory

Indexed keywords

ALLELE; AUTOSOMAL DOMINANT INHERITANCE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE; CELL CYCLE G1 PHASE; COLORECTAL CANCER; DNA MISMATCH REPAIR GENE; DNA REPLICATION; ENDOCRINE TUMOR; ENVIRONMENTAL FACTOR; FAMILIAL CANCER; GAMETE; GENE; GENE FUNCTION; GENE INACTIVATION; GENOTYPE PHENOTYPE CORRELATION; GERM LINE; HEREDITY; HUMAN; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTO ONCOGENE; REVIEW; RISK FACTOR; SOMATIC CELL; TUMOR SUPPRESSOR GENE;

CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NEOPLASMS; PROTO-ONCOGENES;

EID: 4644246162     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-004-0430-4     Document Type: Review

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