Conformationally restricted cationic polyamide analogs of nucleic acids: Design, synthesis, and DNA/RNA binding studies

Pure and Applied Chemistry

Volumn 76, Issue 7-8, 2004, Pages 1599-1603

  Kumar, Vaijayanti A ^a   D'Costa, Moneesha ^a   Lonkar, Pallavi S ^a   Meena, ^a   Pallan, Pradeep S ^a   Ganesh, Krishna N ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEIC ACID; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; RNA;

BINDING AFFINITY; CHEMICAL STRUCTURE; CONFERENCE PAPER; CONFORMATION; DNA BINDING; NUCLEIC ACID SYNTHESIS; RNA BINDING; SOLUBILITY;

EID: 4644228225     PISSN: 00334545     EISSN: None     Source Type: Journal    
DOI: 10.1351/pac200476071599     Document Type: Conference Paper

References (25)

1. (a) C. F. Bennett. In Applied Antisense Oligonucleotide Technology, C. A. Stein and A. M. Craig (Eds.), Wiley-Liss, New York (1998);
2. (b) K. J. Myers and N. M. Dean. Trends Pharmacol Sci. 21, 19 (2000).
3. (a) E. Uhlmann. Curr. Opin. Drug Discovery Dev. 3, 203 (2000);
4. (b) J. Wengel. Acc. Chem. Res. 32, 301 (1999);
5. (c) J. Mickelfield. Curr. Med. Chem. 8, 1157 (2001).
6. P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt. Science 254, 1497 (1991).
7. K. N. Ganesh and P. E. Nielsen. Curr. Org. Chem. 4, 931 (2000).
8. (a) E. Uhlmann, A. Peyman, G. Breipohl, D. W. Will. Angew. Chem., Int. Ed. Engl. 37, 2796 (1998);
9. (b) D. A. Braasch and D. R. Corey. Biochemistry 41, 4503-4510 (2002).
10. (a) B. P. Gangamani, V. A. Kumar, K. N. Ganesh. Tetrahedron 52, 15017 (1996);
11. (b) B. P. Gangamani, V. A. Kumar, K. N. Ganesh. Tetrahedron 55, 177 (1999);
12. (c) V. A. Kumar. Eur. J. Org. Chem. 2021 (2002) and references cited therein.
13. G. Lowe and T. Vilaivan. J. Chem. Soc., Perkin Trans. I 539 (1997).
14. B. Hyrup, M. Egholm, O. Buchardt, P. E. Nielsen. Bioorg. Med. Chem. Lett. 6, 1083 (1996).
15. (a) L. Betts, J. A. Josey, J. M. Veal, S. R. Jordan. Science 270, 1838 (1995);
16. (b) S. C. Brown, S. A. Thomson, J. L. Veal, D. G. Davis. Science 265, 777 (1994);
17. (c) M. Eriksson and P. E. Nielsen. Nat. Struct. Biol. 4, 98 (1997).
18. (a) M. D'Costa, V. A. Kumar, K. N. Ganesh. Org. Lett. 1, 1513 (1999);
19. (b) V. A. Kumar, M. D'Costa, K. N. Ganesh. Nucleosides, Nucleotides and Nucleic Acids 20, 1187 (2001);
20. (c) M. D'Costa, V. A. Kumar, K. N. Ganesh. J. Org. Chem. 68, 4439 (2003);
21. (d) M. D'Costa, V. A. Kumar, K. N. Ganesh. Org. Lett. 3, 1281 (2001).
22. (a) V. A. Kumar, P. S. Pallan, Meena, K. N. Ganesh. Org. Lett. 3, 1269 (2001);
23. (b) V. A. Kumar and Meena. Nucleosides, Nucleotides and Nucleic Acids 22, 1101 (2003).
24. M. D'Costa, V. A. Kumar, K. N. Ganesh. Tetrahedron. Lett. 43, 883 (2002).
25. P. Lonkar and V. Kumar. Nucleosides, Nucleotides and Nucleic Acids 22, 1105 (2003).