Qualitative proof of liquid dispersion and penetration-involved granule formation in a high shear mixer

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 58, Issue 3, 2004, Pages 551-559

  Van Den Dries, Kaspar ^a   Vromans, Herman ^a,b  

^a AKZO NOBEL ^*  (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Binder distribution; Dispersion; Granule breakage; High shear granulation; Liquid penetration; Nucleation

Indexed keywords

HYDROXYPROPYLCELLULOSE; LACTOSE; LIQUID NITROGEN; MAGNESIUM STEARATE; PARACETAMOL;

AQUEOUS SOLUTION; ARTICLE; DISPERSION; HYDROPHOBICITY; LIQUID; QUALITATIVE ANALYSIS;

CHEMISTRY, PHARMACEUTICAL; LACTOSE; PHARMACEUTICAL SOLUTIONS; SHEAR STRENGTH; TECHNOLOGY, PHARMACEUTICAL;

EID: 4644225185     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.04.012     Document Type: Article

References (22)

1. Vromans H., Poels-Janssen H.G.M., Egermann H. Effects of high shear granulation on granulate homogeneity. Pharm. Dev. Technol. 4:1999;297-303
2. Egermann H., Reiss W. Effect of particle size of drug and diluent on drug distribution in granule size fractions. Acta Pharm. Technol. 34:1988;5S
3. K.P. Hapgood, H.E. Hartman, C. Kaur, R. Plank, P. Harmon, J.A. Zega, A case study of drug distribution in wet granulation, World Congress of Particle Technology 4, Sydney, Australia, 21-25 July, 2002.
4. W. Oostra, K. van den Dries, O.M. de Vegt, A. Kariouh, H. Vromans, The influence of binder viscosity and particle size on the composition of the resulting granules, World Congress of Particle Technology 4, Sydney, Australia, 21-25 July, 2002.
5. de Vegt O.M., Oostra W., Damen M., Kok S., Vromans H. A study on the influence of process parameters of a high shear granulation process on the composition of the resulting granules. Proceedings of PARTEC 2001, Nürnberg, Germany. March:2001
6. van den Dries K., Vromans H. Relationship between inhomogeneity phenomena and granule growth mechanisms in a high shear mixer. Int. J. Pharm. 246:2002;167-177
7. van den Dries K., de Vegt O.M., Girard V., Vromans H. Granule breakage phenomena in a high shear mixer; influence of process and formulation variables and consequences on granule homogeneity. Powder Technol. 133:2003;228-236
8. K. van den Dries, H. Vromans, Influence of primary particle size on the layering growth and homogeneity of a granule, Eur. J. Pharm. Sci., Accepted.
9. Schæfer T., Mathiesen M. Melt pelletization in a high shear mixer IX. Effects of binder particle size. Int. J. Pharm. 139:1996;139-148
10. K.P. Hapgood, Nucleation and binder dispersion in wet granulation, PhD Thesis, University of Queensland, Australia, 2000.
11. Vonk P., Guillaume C.P.F., Ramaker J.S., Vromans H., Kossen N.W.F. Growth mechanisms of high shear pelletisation. Int. J. Pharm. 157:1997;93-102
12. Gluba T. The effect of wetting liquid droplet size on growth of agglomerates during wet drum granulation. Powder Technol. 130:2003;219-224
13. S.H. Schaafsma, Down-scaling of a fluidised bed agglomeration process, PhD Thesis, University of Groningen, The Netherlands, 2000.
14. Knight P.C., Instone T., Pearson J.M.K., Hounslow M.J. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technol. 97:1998;246-257
15. Denesuk M., Smith G.L., Zelinski B.J.J., Kreidl N.J., Uhlmann D.R. Capillary penetration of liquid droplets into porous materials. J. Colloid Interface Sci. 158:1993;114-120
16. Middleman S. Modeling axisymmetric flows, dynamics of films, jets and drops. 1995;Academic Press, San Diego
17. Popovich L., Feke D.L., Manas-Zloczower I. Influence of physical and interfacial characteristics on the wetting and spreading of fluids on powders. Powder Technol. 104:1999;68-74
18. Butensky M., Hyman D. Rotary drum granulation. An experimental study of the factors affecting granule size. Ind. Eng. Chem. 10:1971;212-219
19. Carstensen J.T., Lai T., Flickner D., Huber H.E., Zoglio M.A. Physical aspects of wet granulation I: distribution kinetics of water. J. Pharm. Sci. 65:1976;992-997
20. Holm P., Jungersen O., Schæfer T., Kristensen H.G. Granulation in high speed mixers. Part 1: Effects of process variables during kneading. Pharm. Ind. 45:1983;806-811
21. Holm P., Jungersen O., Schæfer T., Kristensen H.G. Granulation in high speed mixers. Part 2: effects of process variables during kneading. Pharm. Ind. 46:1984;97-101
22. Danjo K., Kamiya A., Ikeda E., Torii S., Sunada H., Otsuka A. Influence of granulating fluid in hydroxypropylcellulsoe binder solution on physical properties of lactose granules. Chem. Pharm. Bull. 40:1992;2505-2509