Prostaglandin E 2 inhibits platelet-derived growth factor-stimulated cell proliferation through a prostaglandin e receptor EP2 subtype in rat hepatic stellate cells

Digestive Diseases and Sciences

Volumn 49, Issue 9, 2004, Pages 1394-1400

  Koide, Shigeki ^a   Kobayashi, Yoshimasa ^a   Oki, Yutaka ^a   Nakamura, Hirotoshi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cyclic AMP; hepatic fibrosis; hepatic stellate cells; prostanoid receptors

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; DNA; MESSENGER RNA; ONO AE 1 329; ONO AE 248; ONO AE 259 01; ONO DI 004; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN EP1 RECEPTOR AGONIST; PROSTAGLANDIN EP2 RECEPTOR AGONIST; PROSTAGLANDIN EP3 RECEPTOR AGONIST; PROSTAGLANDIN EP4 RECEPTOR AGONIST; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; PROTEIN INHIBITOR; THYMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; LIVER CELL; LIVER CELL CULTURE; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; DRUG INTERACTION; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP; DINOPROSTONE; DRUG INTERACTIONS; HEPATOCYTES; MALE; MOLECULAR SEQUENCE DATA; PLATELET-DERIVED GROWTH FACTOR; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 4644224728     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:DDAS.0000042236.76194.82     Document Type: Article

References (46)

1. Friedman SL: The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 328:1828-1835, 1993
2. Blomhoff R, Wake K: Perisinusoidal stellate cells of the liver: Important roles in retinol metabolism and fibrosis. FASEB J 5:271-277, 1991
3. De Leeuw AM, McCarthy SP, Geerts A, Knook DL: Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 4:392-403, 1984
4. Rockey DC, Boyles JK, Gabbiani G, Friedman SL: Rat hepatic lipocytes express smooth muscle action upon activation in vivo and in culture. J Submicrosc Cytol Pathol 24:193-203, 1992
5. Ramadori G, Veit T, Schwogler S, Dienes HP, Rieder H, Meyer zum Buschenfelde KH: Expression of the gene of the α-smooth muscle-action isoform in rat liver and in rat fat-storing (Ito) cells. Virchows Arch B Cell Pathol 59:349-357, 1990
6. Ramadori G: The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cells. Virchows Arch B Cell Pathol 61:147-158, 1991
7. Geerts A, De Bleser P, Hautekeete ML, Niki T, Wisse E: Fat-storing (Ito) cell biology. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA (eds). The Liver; Biology and Pathobiology. New York: Raven Press, 994, pp. 819-838
8. Rieder H, Ramadori G, Allmann KH, Meyer zum Buschenfelde KH: Prostanoid release of cultured liver sinusoidal endothelial cells in response to endotoxin and tumor necrosis factor. Comparison with umbilical vein endothelial cells. J Hepatol 11:359-366, 1990
9. Kawada N, Mizoguchi Y, Kobayashi K, Monna T, Morisawa S, Ueda N, Omoto Y, Takahashi Y, Yamamoto S: Possible induction of fatty acid cyclooxygenase in lipopolysaccharide stimulated rat Kupffer cells. Gastroenterology 103:1026-1033, 1992
10. Flisiak R, Baraona E, Li J, Lieber CS: Effects of ethanol on prostanoid production by liver fat-storing cells. Hepatology 18:153-159, 1993
11. Athari A, Hanecke K, Jungermann K: Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. Hepatology 20:142-148, 1994
12. Peters T, Gaillard T, Decker K: Tumor necrosis factor alpha stimulates prostaglandin but not superoxide synthesis in rat Kupffer cells. Eicosanoids 3:115-120, 1990
13. Kawada N, Tran-thi TA, Klein H, Decker K: The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Eur J Biochem 213:815-823, 1993
14. Beno DW, Rapp UR, Davis BH: Prostaglandin E suppression of platelet-derived-growth-factor-induced Ito cell mitogenesis occurs independent of raf perinuclear translocation and nuclear proto-oncogene expression. Biochim Biophys Acta 1222:292-300, 1994
15. Failli P, Defranco RM, Caligiuri A, Gentilini A, Romanelli RG, Marra F, Batignani G, Guerra CT, Laffi G, Gentilini P, Pinzani M: Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells. Gastroenterology 119:479-492, 2000
16. Mallat A, Gallois C, Tao J, Habib A, Maclouf J, Mavier P, Preaux AM, Lotersztajn S: Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostaglandin/cyclic AMP pathway and cross-talk with endothelin receptors. J Biol Chem 273:27300-27305, 1998
17. Mallat A, Preaux AM, Serradeil-LE Gal C, Raufaste D, Gallois C, Brenner DA, Bradham C, Maclouf J, Iourgenko V, Fouassier L, Dhumeaux D, Mavier P, Lotersztajn S: Growth inhibitoiy properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Clin Invest 98:2771-2778, 1996
18. Negishi M, Sugimoto Y, Ichikawa A: Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1259:109-120, 1995
19. Samuelsson B, Goldyne M, Granstrom E, Hamberg M, Hammarstrom S, Malmsten C: Prostaglandins and thromboxanes. Annu Rev Biochem 47:997-1029, 1978
20. Coleman RA, Kennedy I, Humphrey PPA, Bunce K, Lumley P: Prostanoids and their receptors. In: Emmet JC (ed). Comprehensive Medicinal Chemistiy; The Rational Design, Mechanistic Study and Therapeutic Applications of Chemical Compounds. Vol 3. New York: Pergamon Press, 1990, pp 643-714
21. Coleman RA, Grix SP, Head SA, Louttit JB, Mallett A, Sheldrick RL: A novel inhibitoiy prostanoid receptor in piglet saphenous vein. Prostanglandins 47:151-168, 1994
22. Watabe A, Sugimoto Y, Honda A, Me A, Namba T, Negishi M, Ito S, Nammiya S, Ichikawa A: Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. J Biol Chem 268:20175-20178, 1993
23. Funk CD, Furci L, Fitzgerald GA, Grygorczyk R, Rochette C, Bayne MA, Abramovitz M, Adam M, Metters KM: Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem 268:26767-26772, 1993
24. Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbraim CE, Kedzie KM, Woodward DF, Gil DW: Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 46:213-220, 1994
25. Katsuyama M, Nishigaki N, Sugimoto Y, Morimoto K, Negishi M, Nammiya S, Ichikawa A: The mouse prostaglandin E receptor EP2 subtype: Cloning, expression, and northern blot analysis. FEBS Lett 372:151-156, 1995
26. Honda A, Sugimoto Y, Namba T, Watabe A, Irie A, Negishi M, Narumiya S, Ichikawa A: Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype. J Biol Chem 268:7759-7762, 1993
27. An S, Yang J, Xia M, Goetzl EJ: Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. Biochem Biophys Res Commun 197:263-270, 1993
28. Sugimoto Y, Namba T, Honda A, Hayashi Y, Negishi M, Ichikawa A: Cloning and expression of cDNA for mouse prostaglandin E receptor EP3 subtype. J Biol Chem 267:6463-6466, 1992
29. Suzawa T, Miyaura C, Inada M, Maruyama T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T: The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: An analysis using specific agonists for the respective EPs. Endocrinology 141:1554-1559, 2000
30. Shimizu E, Kobayashi Y, Oki Y, Kawasaki T, Nakamura H: OPC-13013, a cyclic nucleotide phosphodiesterase type III inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells. Life Sci 64:2081-2088, 1999
31. Nemoto K, Pilbeam CC, Bilak SR, Raisz LG: Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype. Prostaglandins 54:713-725, 1997
32. Ide K, Hayakawa H, Yagi T, Nakamura H: Decreased expression of Th2 type cytokine mRNA contributes to the lack of allergic bronchial inflammation in aged rats. J Immunol 163:396-402, 1999
33. Okuda A, Shitaka E, Sakamoto K, Ezashi T: Suppression of prostaglandin E receptor signaling by the variant form EP1 subtype. J Biol Chem 271:31255-31261, 1996
34. Takeuchi K, Abe T, Takahashi N, Abe K: Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype. Biochem Biophys Res Commun 194:885-891, 1993
35. Sando T, Usui T, Tanaka I, Mori K, Sasaki Y, Fukuda Y, Namba T, Sugimoto Y, Ichikawa A: Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype. Biochem Biophys Res Commun 200:1329-1333, 1994
36. 2 prostanoid receptor subtypes. Eur J Pharmacol 340:227-241, 1997
37. Steiner AL, Cyclic AMP, cyclic GMP: In: Jaffe BM, Behrman HR eds. Methods of Hormone Radioimmunoassay. Academic Press, New York, 1979, pp 3-16.
38. Ishibashi R, Tanaka I, Kotani M, Nakao K: Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions. Kidney Int 56:589-600, 1999
39. Korn JH, Halushka PV, Leroy EC: Mononuclear cell modulation of connective tissue function: Suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest 65:543-554, 1980
40. Beno DW, Espinal R, Edelstein BM, Davis BH: Administration of prostaglandin E1 analog reduces rat hepatic and Ito cell collagen gene expression and collagen accumulation after bile duct ligation injury. Hepatology 17:707-714, 1993
41. Fennekohl A, Schieferdecker HL, Jungermann K, Puschel GP: Differential expression of prostanoid receptors in hepatocytes, Kupffer cells, sinusoidal endothelial cells and stellate cells of rat liver. J Hepatol 30:38-47, 1999
42. Narumiya S, Sugimoto Y, Ushikubi F: Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79:1193-1226, 1999
43. Kawada N, Kuroki T, Kobayashi K, Inoue M, Kaneda K: Inhibition of myofibroblastic transformation of cultured rat hepatic stellate cells by methylxanthines and dibutyryl cAMP. Dig Dis Sci 41:1022-1029, 1996
44. Houglum K, Lee Ks, Chojkier M: Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest 99:1322-1328, 1997
45. Nishigaki N, Negishi M, Ichikawa A: Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 50:1031-1037, 1996
46. Cospedal R, Lobo M, Zachary I: Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells. Biochem J 342:407-414, 1999