Reentry in survived subepicardium coupled to depolarized and inexcitable midmyocardium: Insights into arrhythmogenesis in ischemia phase 1B

Heart Rhythm

Volumn 5, Issue 7, 2008, Pages 1036-1044

  Jie, Xiao ^a   Rodríguez, Blanca ^b   de Groot, Joris R ^c   Coronel, Ruben ^c   Trayanova, Natalia ^a  

^a Johns Hopkins University   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Arrhythmias; Cellular uncoupling; Computer model; Reentry; Vulnerability

Indexed keywords

ARRHYTHMOGENESIS; ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; EPICARDIUM; EXTRASYSTOLE; HEART CONDUCTION; HEART DEPOLARIZATION; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; IMPEDANCE; MEMBRANE STEADY POTENTIAL; PRIORITY JOURNAL; REFRACTORY PERIOD;

ANIMALS; ARRHYTHMIAS, CARDIAC; COMPUTER SIMULATION; HEART; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PERICARDIUM; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL;

EID: 46349099850     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2008.03.025     Document Type: Article

References (31)

1. Kaplinsky E., Ogawa S., Balke C.W., et al. Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model. Circulation 60 (1979) 397-403
2. de Groot J.R., Wilms-Schopman F.J., Opthof T., et al. Late ventricular arrhythmias during acute regional ischemia in the isolated blood perfused pig heart. Role of electrical cellular coupling. Cardiovasc Res 50 (2001) 362-372
3. Janse M.J., van Capelle F.J., Morsink H., et al. Flow of "injury" current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms. Circ Res 47 (1980) 151-165
4. Pogwizd S.M., and Corr P.B. Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: results using three-dimensional mapping. Circ Res 61 (1987) 352-371
5. Rodríguez B., Trayanova N., and Noble D. Modeling cardiac ischemia. Ann N Y Acad Sci 1080 (2006) 395-414
6. Coronel R., Fiolet J.W., Wilms-Schopman F.J., et al. Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart. Circulation 77 (1988) 1125-1138
7. Carmeliet E. Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol Rev 79 (1999) 917-1017
8. Kléber A.G., Riegger C.B., and Janse M.J. Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle. Circ Res 61 (1987) 271-279
9. de Groot J.R., and Coronel R. Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis. Cardiovasc Res 62 (2004) 323-334
10. Smith W.T.4t., Fleet W.F., Johnson T.A., et al. The Ib phase of ventricular arrhythmias in ischemic in situ porcine heart is related to changes in cell-to-cell electrical coupling. Circulation 92 (1995) 3051-3060
11. Kimura S., Bassett A.L., Gaide M.S., et al. Regional changes in intracellular potassium and sodium activity after healing of experimental myocardial infarction in cats. Circ Res 58 (1986) 202-208
12. Fujiwara H., Ashraf M., Sato S., et al. Transmural cellular damage and blood flow distribution in early ischemia in pig hearts. Circ Res 51 (1982) 683-693
13. Wilensky R.L., J Tranum-Jensen J., Coronel R., et al. The subendocardial border zone during acute ischemia of the rabbit heart: an electrophysiologic, metabolic, and morphologic correlative study. Circulation 74 (1986) 1137-1146
14. Schaapherder A.F.M., Schumacher C.A., Coronel R., et al. Transmural inhomogeneity of extracellular [K+] and pH and myocardial energy metabolism in the isolated rat heart during acute global ischemia; dependence on gaseous environment. Basic Res Cardiol 85 (1990) 33-44
15. Faber G.M., and Rudy Y. Action potential and contractility changes in [Na+]i overloaded cardiac myocytes: a simulation study. Biophys J 78 (2000) 2392-2404
16. Eason J., and Trayanova N. Phase singularities and termination of spiral wave reentry. J Cardiovasc Electrophysiol 13 (2002) 672-679
17. Kléber A.G., and Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84 (2004) 431-488
18. Kléber A.G., Janse M.J., Wilms-Schopmann F.J., et al. Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart. Circulation 73 (1986) 189-198
19. Kwon Y.W., and Bang H. The finite element method using MATLAB. Second Edition (2000), CRC Press, Boca Raton, FL 37-41
20. Plonsey R., Henriquez C., and Trayanova N. Extracellular (volume conductor) effect on adjoining cardiac muscle electrophysiology. Med Biol Eng Comput 26 (1988) 126-129
21. Trayanova N., Eason J., and Aguel F. Computer simulations of cardiac defibrillation: a look inside the heart. Comput Vis Sci 4 (2002) 259-270
22. de Groot JR. Genesis of life-threatening ventricular arrhythmias during the delayed phase of acute ischemia. Role of cellular electrical coupling and myocardial heterogeneities. 2001, PhD Thesis, Thela Thesis Amsterdam, ISBN 90-9014597.
23. Tan R.C., Osaka T., and Joyner R.W. Experimental model of effects on normal tissue of injury current from ischemic region. Circ Res 69 (1991) 965-974
24. Verkerk A.O., Veldkamp M.W., Coronel R., et al. Effects of cell-to-cell uncoupling and catecholamines on Purkinje and ventricular action potentials: implications for phase-1b arrhythmias. Cardiovasc Res 51 (2001) 30-40
25. Spach M.S., Barr R.C., Serwer G.A., et al. Extracellular potentials related to intracellular action potentials in the dog Purkinje system. Circ Res 30 (1972) 505-519
26. Gettes L.S., and Reuter H. Slow recovery from inactivation of inward currents in mammalian myocardial fibres. J Physiol 240 (1974) 703-724
27. Downar E., Janse M.J., and Durrer D. The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart. Circulation 56 (1977) 217-224
28. Kodama I., Wilde A., Janse M.J., et al. Combined effects of hypoxia, hyperkalemia and acidosis on membrane action potential and excitability of guinea-pig ventricular muscle. J Mol Cell Cardiol 16 (1984) 247-259
29. Shaw R.M., and Rudy Y. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 81 (1997) 727-741
30. Panfilov A.V. Is heart size a factor in ventricular fibrillation?. Or how close are rabbit and human hearts?. Heart Rhythm 3 (2006) 862-864
31. Viswanathan P.C., Shaw R.M., and Rudy Y. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation 99 (1999) 2466-2474