Effects of particles on the cardiovascular system

Particle Toxicology

Volumn , Issue , 2006, Pages 259-273

  Mills, Nicholas L ^a   Newby, David E ^a   MacNee, William ^b   Donaldson, Ken ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 46349095781     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (84)

1. Blum, A. and Miller, H. I., The role of inflammation in atherosclerosis, Isr. J. Med. Sci., 32, 1059-1065, 1996.
2. Bonetti, P. O., Lerman, L. O., and Lerman, A., Endothelial dysfunction: a marker of atherosclerotic risk, Arterioscler. Thromb. Vasc. Biol., 23, 168-175, 2003.
3. Brand, K., Page, S., Rogler, G., Bartsch, A., Brandl, R., Knuechel, R., Page, M., Kaltschmidt, C., Baeuerle, P.A., and Neumeier, D., Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion, J. Clin. Invest., 97, 1715-1722, 1996.
4. Brommer, E. J., The level of extrinsic plasminogen activator (t-PA) during clotting as a determinant of the rate of fibrinolysis; inefficiency of activators added afterwards, Thromb. Res., 34, 109-115, 1984.
5. Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., and Silverman, F., Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults, Circulation, 105, 1534-1536, 2002.
6. Brook, R. D., Brook, J. R., and Rajagopalan, S., Air pollution: the Heart of the problem, Curr. Hypertens. Rep., 5, 32-39, 2003.
7. Brook, R. D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R. et al., Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association, Circulation, 109, 2655-2671, 2004.
8. 2.5 in ozone pre-exposed or monocrotaline-treated rats, Inhal. Toxicol., 14, 721-743, 2002.
9. Celermajer, D. S., Adams, M. R., Clarkson, P., Robinson, J., McCredie, R., Donald, A., and Deanfield, J. E., Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults, N. Engl. J. Med., 334, 150-154, 1996.
10. Chen, L. C. and Nadziejko, C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice, Inhal. Toxicol., 17, 217-224, 2005.
11. Committee on the Medical Effects of Air Pollutants, Cardiovascular disease and air pollution, Department of Health, 2006, Ref Type: Generic.
12. Creason, J., Neas, L., Walsh, D., Williams, R., Sheldon, L., Liao, D., and Shy, C., Particulate matter and heart rate variability among elderly retirees: the Baltimore 1998 PM study, J. Expo. Anal. Environ. Epidemiol., 11, 116-122, 2001.
13. Davies, M. J., Coronary disease: the pathophysiology of acute coronary syndromes, Heart, 83, 361-366, 2000.
14. Ref Type: Generic Devlin, R. B., Ghio, A. J., Kehrl, H., Sanders, G., and Cascio, W., Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability, Eur. Respir. J. Suppl., 40, 76s-80s, 2003.
15. Dockery, D. W., Pope, C. A., Xu, X. P., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., and Speizer, F. E., An association between air-pollution and mortality in 6 united-states cities, N. Engl. J. Med., 329, 1753-1759, 1993.
16. Donaldson, K. and Tran, C. L., Inflammation caused by particles and fibres, Inhal. Toxicol., 14, 2002.
17. Donaldson, K., Tran, L., Jimenez, L., Duffin, R., Newby, D. E., Mills, N., MacNee, W., and Stone, V., Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure, Part. Fibre Toxicol., 2, 10, 2005.
18. Eijnden-Schrauwen, Y., Kooistra, T., de Vries, R. E., and Emeis, J. J., Studies on the acute release of tissuetype plasminogen activator from human endothelial cells in vitro and in rats in vivo: evidence for a dynamic storage pool, Blood, 85, 3510-3517, 1995.
19. Elder A. P., Gelein, R., Azadniv, M., Frampton, M. W., Finkelstein, J., and Oberdörster, G., Systemic interactions between inhaled ultrafine particles and endotoxin, 2002, Ref Type: Generic.
20. Elder, A., Gelein, R., Finkelstein, J., Phipps, R., Frampton, M., Utell, M., Kittelson, D. B. et al., On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats, Inhal. Toxicol., 16 (suppl. 1), 41-53, 2004.
21. Fox, K. A., Robison, A. K., Knabb, R. M., Rosamond, T. L., Sobel, B. E., and Bergmann, S. R., Prevention of coronary thrombosis with subthrombolytic doses of tissue-type plasminogen activator, Circulation, 72, 1346-1354, 1985.
22. Furchgott, R. F. and Zawadzki, J. V., The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, 288, 373-376, 1980.
23. Ghio, A. J. and Devlin, R. B., Inflammatory lung injury after bronchial instillation of air pollution particles, Am. J. Respir. Crit. Care Med., 164, 704-708, 2001.
24. Ghio, A. J., Kim, C., and Devlin, R. B., Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers, Am. J. Respir. Crit. Care Med., 162, 981-988, 2000.
25. 10), Occup. Environ. Med., 62, 164-171, 2005.
26. Glantz, S. A., Air pollution as a cause of heart disease. Time for action, J. Am. Coll. Cardiol., 39, 943-945, 2002.
27. Gold, D. R., Litonjua, A., Schwartz, J., Lovett, E., Larson, A., Nearing, B., Allen, G., Verrier, M., Cherry, R., and Verrier, R., Ambient pollution and heart rate variability, Circulation, 101, 1267-1273, 2000.
28. Goldberg, M. S., Burnett, R. T., Valois, M. F., Flegel, K., Bailar, J. C., III, Brook, J., Vincent, R., and Radon, K., Associations between ambient air pollution and daily mortality among persons with congestive heart failure Environ. Res., 91 2003.
29. Goto, Y., Hogg, J. C., Shih, C. H., Ishii, H., Vincent, R., and van Eeden, S. F., Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits, Am. J. Physiol. Lung Cell Mol. Physiol., 287, L79-L85, 2004.
30. Guzman, M., Aberturas, M. R., Rodriguez-Puyol, M., and Molpeceres, J., Effect of nanoparticles on digitoxin uptake and pharmacologic activity in rat glomerular mesangial cell cultures, Drug Deliv., 7, 215-222, 2000.
31. Haverkate, F., Thompson, S. G., Pyke, S. D., Gallimore, J. R., and Pepys, M. B., Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group, Lancet, 349, 462-466, 1997.
32. Hingorani, A. D., Cross, J., Kharbanda, R. K., Mullen, M. J., Bhagat, K., Taylor, M., Donald, A. E. et al., Acute systemic inflammation impairs endothelium-dependent dilatation in humans, Circulation, 102, 994-999, 2000.
33. Holgate, S. T., Devlin, R. B., Wilson, S. J., and Frew, A. J., Health effects of acute exposure to air pollution. Part II: healthy subjects exposed to concentrated ambient particles, Res. Rep. Health Eff. Inst., 31-50, 2003.
34. Khandoga, A., Stampfl, A., Takenaka, S., Schulz, H., Radykewicz, R., Kreyling, W., and Krombach, F., Ultrafine particles exert prothrombotic but not inflammatory effects on the hepatic microcirculation in healthy mice in vivo, Circulation, 109, 1320-1325, 2004.
35. Kleiger, R. E., Heart rate variability and mortality and sudden death post infarction, J. Cardiovasc. Electrophysiol., 6, 365-367, 1995.
36. Kreyling, W., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Oberdörster, G., and Ziesenis, A., Minute translocation of inhlaed ultrafine insoluble iridium particles from lung epithelium to extrapulmonary tissues, Ann. Occup. Hyg., 46 (suppl. 1), 223-226, 2002a.
37. Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdörster, G., and Ziesenis, A., Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low, J. Toxicol. Environ. Health A, 65, 1513-1530, 2002b.
38. Kuller, L. H., Tracy, R. P., Shaten, J., and Meilahn, E. N., Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial, Am. J. Epidemiol., 144, 537-547, 1996.
39. Kunzli, N., Jerrett, M., Mack, W. J., Beckerman, B., LaBree, L., Gilliland, F., Thomas, D., Peters, J., and Hodis, H. N., Ambient air pollution and atherosclerosis in Los Angeles, Environ. Health Perspect., 113, 201-206, 2005.
40. Labinjoh, C., Newby, D. E., Dawson, P., Johnston, N. R., Ludlam, C. A., Boon, N. A., and Webb, D. J., Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man, Cardiovasc. Res., 47, 707-714, 2000.
41. Lee, R. T. and Libby, P., The unstable atheroma, Arterioscler. Thromb. Vasc. Biol., 17, 1859-1867, 1997.
42. 10) in vivo and in vitro, Thorax, 51, 1216-1222, 1996.
43. Liao, D., Creason, J., Shy, C., Williams, R., Watts, R., and Zweidinger, R., Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly, Environ. Health Perspect., 107, 521-525, 1999.
44. Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., and Maseri, A., The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina, N. Engl. J. Med., 331, 417-424, 1994.
45. Ludmer, P. L., Selwyn, A. P., Shook, T. L., Wayne, R. R., Mudge, G. H., Alexander, R. W., and Ganz, P., Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries, N. Engl. J. Med., 315, 1046-1051, 1986.
46. Magari, S. R., Schwartz, J., Williams, P. L., Hauser, R., Smith, T. J., and Christiani, D. C., The association between personal measurements of environmental exposure to particulates and heart rate variability, Epidemiology, 13, 305-310, 2002.
47. Mills, N. L., Tornqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., MacNee, W., Boon, N. A. et al., Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis, Circulation, 112, 3930-3936, 2005.
48. Mills, N. L., Amin, N., Robinson, S. D., Anand, A., Davies, J., Patel, D., de la Fuente, J. M. et al., Do inhaled carbon nanoparticles translocate directly into the circulation in humans?, Am. J. Respir. Crit. Care Med., 173, 426-431, 2006.
49. Nemmar, A., Vanbilloen, H., Hoylaerts, M. F., Hoet, P. H., Verbruggen, A., and Nemery, B., Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster, Am. J. Respir. Crit. Care Med., 164, 1665-1668, 2001.
50. Nemmar, A., Hoet, P. H., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B., Passage of inhaled particles into the blood circulation in humans, Circulation, 105, 411-414, 2002.
51. Nemmar, A., Hoet, P. H., Dinsdale, D., Vermylen, J., Hoylaerts, M. F., and Nemery, B., Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis, Circulation, 107, 1202-1208, 2003a.
52. Nemmar, A., Hoylaerts, M. F., Hoet, P. H., Vermylen, J., and Nemery, B., Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis, Toxicol. Appl. Pharmacol, 186, 38-45, 2003b.
53. Nemmar, A., Nemery, B., Hoet, P. H., Vermylen, J., and Hoylaerts, M. F., Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine, Am. J. Respir. Crit. Care Med, 168, 1366-1372, 2003c.
54. Nemmar, A., Hoylaerts, M. F., Hoet, P. H., and Nemery, B., Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects, Toxicol. Lett., 149, 243-253, 2004.
55. Newby, D. E., Wright, R. A., Labinjoh, C., Ludlam, C. A., Fox, K. A., Boon, N. A., and Webb, D. J., Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction, Circulation, 99, 1411-1415, 1999.
56. Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A. P., Gelein, R., Lunts, A. K., Kreyling, W., and Cox, C., Extrapulmonary transocation of ultrafine carbon particles following inhalation exposure, 2002, Ref Type: Generic.
57. Oliver, J. J., Webb, D. J., and Newby, D. E., Stimulated tissue plasminogen activator release as a marker of endothelial function in humans 1, Arterioscler. Thromb. Vasc. Biol., 25, 2470-2479, 2005.
58. Pekkanen, J., Brunner, E. J., Anderson, H. R., Tiittanen, P., and Atkinson, R. W., Daily concentrations of air pollution and plasma fibrinogen in London, Occup. Environ. Med., 57, 818-822, 2000.
59. Peters, A., Doring, A., Wichmann, H. E., and Koenig, W., Increased plasma viscosity during an air pollution episode: a link to mortality?, Lancet, 349, 1582-1587, 1997.
60. Peters, A., Perz, S., Doring, A., Stieber, J., Koenig, W., and Wichmann, H. E., Increases in heart rate during an air pollution episode, Am. J. Epidemiol., 150, 1094-1098, 1999.
61. Peters, A., Liu, E., Verrier, R. L., Schwartz, J., Gold, D. R., Mittleman, M., Baliff, J. et al., Air pollution and incidence of cardiac arrhythmia, Epidemiology, 11, 11-17, 2000.
62. Peters, A., Dockery, D. W., Muller, J. E., and Mittleman, M. A., Increased particulate air pollution and the triggering of myocardial infarction, Circulation, 103, 2810-2815, 2001a.
63. Peters, A., Frohlich, M., Doring, A., Immervoll, T., Wichmann, H. E., Hutchinson, W. L., Pepys, M. B., and Koenig, W., Particulate air pollution is associated with an acute phase response in men; results from the MONICA-Augsburg Study, Eur. Heart J, 22, 1198-1204, 2001b.
64. Pope, C. A., III, Particulate air pollution, C-reactive protein, and cardiac risk, Eur. Heart J., 22, 1149-1150, 2001.
65. Pope, C. A., III, Verrier, R. L., Lovett, E. G., Larson, A. C., Raizenne, M. E., Kanner, R. E., Schwartz, J., Villegas, G. M., Gold, D. R., and Dockery, D. W., Heart rate variability associated with particulate air pollution, Am. Heart J., 138, 890-899, 1999.
66. Prescott, G. J., Lee, R. J., Cohen, G. R., Elton, R. A., Lee, A. J., Fowkes, F. G., and Agius, R. M., Investigation of factors which might indicate susceptibility to particulate air pollution, Occup. Environ. Med., 57, 53-57, 2000.
67. Radomski, A., Jurasz, P., Alonso-Escolano, D., Drews, M., Morandi, M., Malinski, T., and Radomski, M. W., Nanoparticle-induced platelet aggregation and vascular thrombosis, Br. J. Pharmacol., 146, 882-893, 2005.
68. Reddigari, S. and Kaplan, A. P., Cleavage of human high-molecular weight kininogen by purified kallikreins and upon contact activation of plasma 32, Blood, 71, 1334-1340, 1988.
69. Ridker, P. M., Hennekens, C. H., Buring, J. E., and Rifai, N., C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women, N. Engl. J. Med, 342, 836-843, 2000a.
70. Ridker, P. M., Rifai, N., Stampfer, M. J., and Hennekens, C. H., Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men, Circulation, 101, 1767-1772, 2000b.
71. Rosenberg, R. D. and Aird, W. C., Vascular-bed-specific hemostasis and hypercoagulable states, N. Engl. J. Med., 340, 1555-1564, 1999.
72. Ross, R., The pathogenesis of atherosclerosis: a perspective for the 1990s, Nature, 362, 801-809, 1993.
73. Ross, R., Atherosclerosis is an inflammatory disease, Am. Heart J., 138, S419-S420, 1999.
74. Routledge, H. C., Ayres, J. G., and Townend, J. N., Why cardiologists should be interested in air pollution, Heart, 89, 1383-1388, 2003.
75. Schwartz, J., Air pollution and blood markers of cardiovascular risk, Environ. Health Perspect., 109 (suppl. 3), 405-409, 2001.
76. Schwartz, J., The effects of particulate air pollution on daily deaths: a multi-city case crossover analysis, Occup. Environ. Med., 61, 956-961, 2004.
77. Seaton, A., Soutar, A., Crawford, V., Elton, R., McNerlan, S., Cherrie, J., Watt, M., Agius, R., and Stout, R., Particulate air pollution and the blood, Thorax, 54, 1027-1032, 1999.
78. Sun, Q., Wang, A., Jin, X., Natanzon, A., Duquaine, D., Brook, R. D., Aguinaldo, J. G. et al., Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model, JAMA, 294, 3003-3010, 2005.
79. Suwa, T., Hogg, J. C., Quinlan, K. B., Ohgami, A., Vincent, R., and van Eeden, S. F., Particulate air pollution induces progression of atherosclerosis, J. Am. Coll. Cardiol., 39, 935-942, 2002.
80. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, Heart rate variability. Standards of measurement, physiological interpretation, and clinical use, Eur. Heart J., 17, 354-381, 1996.
81. Tsuji, H., Venditti, F. J., Manders, E. S., Evans, J. C., Larson, M. G., Feldman, C. L., and Levy, D., Determinants of heart rate variability, J. Am. Coll. Cardiol., 28, 1539-1546, 1996.
82. 10), Am. J. Respir. Crit. Care Med., 164, 826-830, 2001.
83. Vincent, R., Kumarathasan, P., Geogan, P., Bjarnason, S. G., Guenette, J., BéruBé, D., Adamson, I. Y. et al., Inhalation Toxicology of Urban Ambient Particulate Matter: Acute Cardiovascular Effects in Rats, Health Effects Research Report No. 104, 2001.
84. Wellenius, G. A., Saldiva, P. H., Batalha, J. R., Krishna Murthy, G. G., Coull, B. A., Verrier, R. L., and Godleski, J. J., Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction, J. Toxicol. Sci., 66, 327-335, 2002.