Determination of brominated flame retardants in food by LC–MS/MS: Diastereoisomer-specific hexabromocyclododecane and tetrabromobisphenol A

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment

Volumn 25, Issue 7, 2008, Pages 895-903

  Driffield, Malcolm ^a   Harmer, Nick ^a   Bradley, Emma ^a   Fernandes, Alwyn R ^a   Rose, Martin ^a   Mortimer, David ^b   Dicks, Pamela ^b  

^a FOOD AND ENVIRONMENT RESEARCH AGENCY   (United Kingdom)

^b FOOD STANDARDS AGENCY   (United Kingdom)

Author keywords

Brominated flame retardants (BFRs); Diastereoisomer specific hexabromocyclododecane (HBCD); LC MS MS; Shellfish; Tetrabromobisphenol A (TBBPA); Total diet study (TDS)

Indexed keywords

FLAME RETARDANT; HEXABROMOCYCLODODECANE; TETRABROMOBISPHENOL A; OIL;

ARTICLE; CHEMICAL BINDING; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FOOD ANALYSIS; FOOD CONTAMINATION; LIQUID CHROMATOGRAPHY; METHODOLOGY; MUSSEL; OYSTER; PRIORITY JOURNAL; SCALLOP; TANDEM MASS SPECTROMETRY; UNITED KINGDOM; BIOTRANSFORMATION; BREAD; CARCASS; CEREAL; DAIRY PRODUCT; DIASTEREOISOMER; DIETARY INTAKE; EGG; ENVIRONMENTAL EXPOSURE; FAT INTAKE; FISH; FOOD BIOTECHNOLOGY; FOOD COMPOSITION; FOOD SAFETY; FRUIT; MEAT; NUT; SHELLFISH; SUGAR INTAKE; VEGETABLE;

OSTREIDAE; PECTINIDAE;

ANIMALS; CHROMATOGRAPHY, LIQUID; ENVIRONMENTAL EXPOSURE; FLAME RETARDANTS; FOOD CONTAMINATION; HYDROCARBONS, BROMINATED; MASS SPECTROMETRY; MAXIMUM ALLOWABLE CONCENTRATION; POLYBROMINATED BIPHENYLS; RISK FACTORS; SHELLFISH; WATER POLLUTANTS;

EID: 46349086981     PISSN: 19440049     EISSN: 19440057     Source Type: Journal    
DOI: 10.1080/02652030701882999     Document Type: Article

References (24)

1. Asplund, JL, Bignert, A, and Nylund, K. 2004. Comparison of spatial and temporal trends of methyoxylated PBDEs, PBDEs, and hexabromocyclododecane in herring along the Swedish coast. Organohalogen Compounds, 66:3988–3993.
2. COT. 2003. Committee on Toxicity of Chemicals in Food, Consumer Products and Environment. COT statement on brominated flame retardants from Skerne–Tees river systems, Available:http://www.food.gov.uk/science/ouradvisors/toxicity/statements/cotstatements2003. Accessed:16 November 2007
3. COT. 2004. Committee on toxicity of chemicals in food, consumer products and environment. COT statement on TBBPA. Review of toxicological data, Available:http://www.food.gov.uk/multimedia/pdfs/cotstatements04tbbpa.pdf. Accessed:16 November 2007
4. Darnerud, PO. 2003. Toxic effects of brominated flame retardants in man and in wildlife. Environ Int, 29:841–853.
5. Dodder, NG, Peck, AM, Kucklick, JR, and Sander, LC. 2006. Analysis of hexabromocyclododecane diastereomers and enantiomers by liquid chromatography/tandem mass spectrometry:Chromatographic selectivity and ionization matrix effects. J Chromatogr A, 1135:36–42.
6. D'Silva, K, Fernandes, A, and Rose, M. 2004. Brominated organic micropollutants. Igniting the flame retardant issue. Crit Rev Env Sci Tec, 34:141–207.
7. Fernandes, A, White, S, D'Silva, K, and Rose, M. 2004. Simultaneous determination of PCDDs, PCDFs, PCBs and PBDEs in food. Talanta, 63:1147–1155.
8. Fernandes, A, D'Silva, K, Driffield, M, White, S, and Rose, M. 2005. Report to the Food Standards Agency:CSL Report FD 04/37, Available from CSL
9. Fernandes, A, Dicks, P, Mortimer, D, Gem, M, Smith, F, Driffield, M, White, S, and Rose, M. 2007. Brominated and chlorinated dioxins and brominated flame retardants in Scottish shellfish:Methodology, occurrence and human dietary exposure. Molecular Nutrition and Food Research, 52:238–249.
10. Food Standards Agency. 2007a. Brominated flame retardants in trout and eels from the Skerne–Tees river system, Available:http://www.food.gov.uk/multimedia/pdfs/fsis5204.pdf. Accessed:16 November 2007
11. Food Standards Agency. 2007b. Brominated chemicals in farmed and wild fish and shellfish and fish oil dietary supplements, Available:http://www.food.gov.uk/multimedia/pdfs/fsis0406.pdf. Accessed:16 November 2007
12. Food Standards Agency. 2007c. Collection and analysis of shellfish flesh from Scottish in-shore and offshore harvesting areas for chemical contaminants, Available:http://www.food.gov.uk/science/research/researchinfo/devolvedadmins/scotlandresearch/scotlandresearch/ScotlandProjectList/s1402627/. Accessed:16 November 2007
13. Food Standards Agency. 2007d. Brominated chemicals:UK dietary intake, Available:http://www.food.gov.uk/multimedia/pdfs/fsis1006.pdf. Accessed:16 November 2007
14. Hakk, H, and Letcher, R. 2003. Metabolism in the toxicokinetics and fate of brominated flame retardants. A review. Environ Int, 29:801–828.
15. Hale, RC, Alaee, M, Manchester-Neesvig, JB, Stapleton, HM, and Ikonomou, MG. 2003. Polybrominated diphenyl ether flame retardants in the North American environment. Environ Int, 29:771–779.
16. Law, K, Palace, VP, Halldorson, T, Danell, R, Wautier, K, Evans, B, Alaee, M, Marvin, C, and Tomy, GT. 2006. Dietary accumulation of hexabromocyclododecane diastereoisomers in juvenile rainbow trout (Oncorhynchus mykiss). I. Bioaccumulation parameters and evidence of bioisomerization. Environ Toxicol Chem, 25:1757–1761.
17. Law, RJ, Bersuder, P, Allchin, CR, and Barry, J. 2006. Levels of the flame retardants hexabromocyclododecane and tetrabromobisphenol A in the blubber of harbor porpoises (Phocoena phocoena) stranded or bycaught in the UK, with evidence for an increase in HBCD concentrations in recent years. Environ Sci Technol, 40:2177–2183.
18. Peattie, ME, Buss, DH, Lindsey, DG, and Smart, GA. 1983. Reorganization of the British total diet study for monitoring food constituents from 1981. Food Chem Toxicol, 21:503–507.
19. Remberger, M, Sternback, J, Palm, A, Kaj, L, Stromberg, K, and Brorstrom-Lunden, E. 2004. The environmental occurrence of HBCD in Sweden. Chemosphere, 54:9–21.
20. Schecter, A, and Gasiewicz, T. 2003. Dioxins and Health, 2nd edition, Hoboken, NJ:Wiley.
21. Suzuki, S, and Hasegawa, A. 2006. Determination of hexabromocyclododecane diastereoisomers and tetrabromobisphenol A in water and sediment by liquid chromatography/mass spectrometry. Anal Sci, 22:469–474.
22. Tollback, J, Crescenzi, C, and Dyremark, E. 2006. Determination of the flame retardant tetrabromobisphenol A in air samples by liquid chromatography–mass spectrometry. J Chromatogr A, 1104:106–112.
23. Winter Sorkina, R, Bakker, MI, van Donkersgoed, G, and van Klaveren, JD. 2003. Dietary intake of brominated flame retardants by the Dutch population. RIKILT report, Available:www.rikilt.wur.nl/Publicaties/Rapporten/RIKILT2003.019.pdf. Accessed:16 November 2007
24. Zegers, BN, Mets, A, van Bommel, R, Minkenberg, C, Hamers, T, Kamstra, JK, Pierce, GJ, and Boon, JP. 2005. Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome P450. Environ Sci Tec, 39:2095–2100.