Possible neuroprotective mechanism of human neuroglobin

Annals of the New York Academy of Sciences

Volumn 1053, Issue , 2005, Pages 220-230

  Wakasugi, Keisuke ^a,b   Kitatsuji, Chihiro ^a   Morishima, Isao ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Neuroglobin (Ngb); Neuroprotection; Oxidative stress; Protein protein interaction

Indexed keywords

BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROGLOBIN;

ALPHA CHAIN; ANIMAL CELL; BRAIN FUNCTION; BRAIN PERFUSION; CELL SURVIVAL; CONFERENCE PAPER; GENE EXPRESSION REGULATION; HYPOXIA; MAMMAL CELL; MOLECULAR MECHANICS; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXYGEN AFFINITY; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA; VERTEBRATA;

EID: 29744432405     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1344.020     Document Type: Conference Paper

References (56)

1. BURMESTER, T., B. WEICH, S. REINHARDT & T. HANKELN. 2000. A vertebrate globin expressed in the brain. Nature 407: 520-523.
2. AWENIUS, C., T. HANKELN & T. BURMESTER. 2001. Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Biochem. Biophys. Res. Commun. 287:418-421.
3. DEWILDE, S., L. KIGER, T. BURMESTER et al. 2001. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J. Biol. Chem. 276: 38949-38955.
4. TRENT, J.T., R.A. WATTS & M.S. HARGROVE. 2001. Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen. J. Biol. Chem. 276: 30106-30110.
5. ERECINSKA, M. & I.A. SILVER. 2001. Tissue oxygen tension and brain sensitivity to hypoxia. Respir. Physiol. 128: 263-276.
6. GEUENS, E., I. BROUNS, D. FLAMEZ et al. 2003. A globin in the nucleus. J. Biol. Chem. 278: 30417-30420.
7. SCHMIDT, M., A. GIEL, T. LAUFS et al. 2003. How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. J. Biol. Chem. 278: 1932-1935.
8. LAUFS, T.L., S. WYSTUB, S. REUSS et al. 2004. Neuron-specific expression of neuroglobin in mammals. Neurosci. Lett. 362: 83-86.
9. SUN, Y., K. JIN, X.O. MAO et al. 2001. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc. Natl. Acad. Sci. USA 98: 15306-15311.
10. SUN, Y., K. JIN, A. PEEL et al. 2003. Neuroglobin protects the brain from experimental stroke in vivo. Proc. Natl. Acad. Sci. USA 100: 3497-3500.
11. PITCHER, J.A., N.J. FREEDMAN & R.J. LEFKOWITZ. 1998. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67: 653-692.
12. ZHENG, B., L. DE VRIES & M.G. FARQUHAR. 1999. Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies. Trends Biochem. Sci. 24:411-414.
13. GILMAN, A.G. 1987. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56: 615-649.
14. HEPLER, J.R. & A.G. GILMAN. 1992. G proteins. Trends Biochem. Sci. 17: 383-387.
15. SPRANG, S.R. 1997. G protein mechanisms: insights from structural analysis. Annu. Rev. Biochem. 66: 639-678.
16. i/o binding motif and potential guanine-nucleotide-exchange factor. Trends Biochem. Sci. 24:340-341.
17. WILLARD, F.S., R.J. KIMPLE & D.P. SIDEROVSKI. 2004. Return of the GDI: the GoLoco motif in cell division. Annu. Rev. Biochem. 73: 925-951.
18. WAKASUGI, K., T. NAKANO & I. MORISHIMA. 2003. Oxidized human neuroglobin as a heterotrimeric Gα protein guanine nucleotide dissociation inhibitor. J. Biol. Chem. 278: 36505-36512.
19. ESPLUGUES, J.V. 2002. NO as a signaling molecule in the nervous system. Br. J. Pharmacol. 135: 1079-1095.
20. DRÖGE, W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82: 47-95.
21. BRUNORI, M. 2001. Nitric oxide moves myoglobin center stage. Trends Biochem. Sei. 26: 209-210.
22. FLÖGEL, U., M.W. MERX, A. GÖDECKE et al. 2001. Myoglobin: a scavenger of bioactive NO. Proc. Natl. Acad. Sci. USA 98: 735-740.
23. JOSHI, M.S., T.B. FERGUSON, JR., T.H. HAN et al. 2002. Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions. Proc. Natl. Acad. Sci. USA 99: 10341-10346.
24. MAMMEN, P.P.A., J.M. SHELTON, S.C. GOETSCH et al. 2002. Neuroglobin, a novel member of the globin family, is expressed in focal regions of the brain. J. Histochem. Cytochem. 50: 1591-1598.
25. o are target proteins of reactive oxygen species. Nature 408: 492-495.
26. i and G0 by reactive oxygen species. J. Biol. Chem. 277: 9036-9042.
27. LEWERENZ, J., J. LETZ & A. METHNER. 2003. Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress. J. Neurochem. 87: 522-531.
28. AIKAWA, R., I. KOMURO, T. YAMAZAKI et al. 1997. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J. Clin. Invest. 100: 1813-1821.
29. SONODA, Y., S. WATANABE, Y. MATSUMOTO et al. 1999. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J. Biol. Chem. 274: 10566-10570.
30. SCHWINDINGER, W.F. & J.D. ROBISHAW. 2001. Heterotrimeric G-protein βγ-dimers in growth and differentiation. Oncogene 20: 1653-1660.
31. FUCHS, C., V. HEIB, L. KIGER et al. 2004. Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding. J. Biol. Chem. 279: 24116-24122.
32. GO, M. 1981. Correlation of DNA exonic regions with protein structural units in haemoglobin. Nature 291: 90-92.
33. WAKASUGI, K. & I. MORISHIMA. 2005. Identification of residues in human neuroglobin crucial for guanine nucleotide dissociation inhibitor activity. Biochemistry 44: 2943-2948.
34. WAKASUGI, K., K. ISHIMORI, K. IMAI et al. 1994. "Module" substitution in hemoglobin subunits: preparation and characterization of a "chimera βα-subunit". J. Biol. Chem. 269: 18750-18756.
35. WAKASUGI, K., K. ISHIMORI & I. MORISHIMA. 1997. "Module"- substituted globins: artificial exon shuffling among myoglobin, hemoglobin α- and β-subunits. Biophys. Chem. 68: 265-273.
36. WAKASUGI, K., C. QUINN, N. TAO & P. SCHIMMEL. 1998. Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant. EMBO J. 17: 297-305.
37. PESCE, A., S. DEWILDE, M. NARDINI et al. 2003. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure 11: 1087-1095.
38. TARRICONE, C., A. GALIZZI, A. CODA et al. 1997. Unusual structure of the oxygen-binding site in the dimeric bacterial hemoglobin from Vitreoscilla sp. Structure 5: 497-507.
39. LEE, S.Y., B.C. STARK & D.A. WEBSTER. 2004. Structure-function of the Vitreoscilla hemoglobin D-region. Biochem. Biophys. Res. Commun. 316: 1101-1106.
40. q/11 interaction: a novel surface on a regulator of G protein signaling homology domain for binding Gα subunits. J. Biol. Chem. 276: 6050-6058.
41. WAKASUGI, K., T. NAKANO, C. KITATSUJI & I. MORISHIMA. 2004. Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. Biochem. Biophys. Res. Commun. 318: 453-460.
42. SCHULTE, T., K.A. PASCHKE, U. LAESSING et al. 1997. Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration. Development 124: 577-587.
43. BICKEL, P.E., P.E. SCHERER, J.E. SCHNITZER et al. 1997. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 272: 13793-13802.
44. MAEKAWA, S., S. IINO & S. MIYATA. 2003. Molecular characterization of the detergent-insoluble cholesterol-rich membrane microdomain (raft) of the central nervous system. Biochim. Biophys. Acta 1610: 261-270.
45. BAUMANN, C.A., V. RIBON, M. KANZAKI et al. 2000. CAP defines a second signaling pathway required for insulin-stimulated glucose transport. Nature 407: 202-207.
46. KIMURA, A., C.A. BAUMANN, S.H. CHIANG & A.R. SALTIEL. 2001. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Proc. Natl. Acad. Sci. USA 98: 9098-9103.
47. MOFFETT, S., D.A. BROWN & M.E. LINDER. 2000. Lipid-dependent targeting of G proteins into rafts. J. Biol. Chem. 275: 2191-2198.
48. OH, P. & J.E. SCHNITZER. 2001. Segregation of heterotrimeric G proteins in cell surface microdomains: G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol. Biol. Cell 12: 685-698.
49. WAKASUGI, K., T. NAKANO & I. MORISHIMA. 2004. Association of human neuroglobin with cystatin C, a cysteine proteinase inhibitor. Biochemistry 43: 5119-5125.
50. NISHIO, C., K. YOSHIDA, K. NISHIYAMA et al. 2000. Involvement of cystatin C in oxidative stress-induced apoptosis of cultured rat CNS neurons. Brain Res. 873: 252-262.
51. TSUCHIYA, K., Y. KOHDA, M. YOSHIDA et al. 1999. Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors. Exp. Neurol. 155: 187-194.
52. GRAY, J., M.M. HARAN, K. SCHNEIDER et al. 2001. Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone. J. Biol. Chem. 276: 32750-32755.
53. KOHDA, Y., T. YAMASHIMA, K. SAKUDA et al. 1996. Dynamic changes of cathepsins B and L expression in the monkey hippocampus after transient ischemia. Biochem. Biophys. Res. Commun. 228: 616-622.
54. KAGEDAL, K., U. JOHANSSON & K. ÖLLINGER. 2001. The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress. FASEB J. 15: 1592-1594.
55. MERZ, G.S., E. BENEDIKZ, V. SCHWENK et al. 1997. Human cystatin C forms an inactive dimer during intracellular trafficking in transfected CHO cells. J. Cell. Physiol. 173: 423-432.
56. ABRAHAMSON, M. & A. GRUBB. 1994. Increased body temperature accelerates aggregation of the Leu68→Gln mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy. Proc. Natl. Acad. Sci. USA 91: 1416-1420.