Association of genetic variation in ENPP1 with obesity-related phenotypes

Obesity

Volumn 16, Issue 7, 2008, Pages 1708-1713

  Jenkinson, Christopher P ^a,b,c   Coletta, Dawn K ^a   Flechtner Mors, Marion ^d   Hu, Shirley L ^c   Fourcaudot, Marcel J ^a   Rodriguez, Lenore M ^a   Schneider, Jennifer ^b   Arya, Rector ^a   Stern, Michael P ^a   Blangero, John ^b   Duggirala, Ravindranath ^b   DeFronzo, Ralph A ^a,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INORGANIC PYROPHOSPHATASE; LEPTIN; PHOSPHODIESTERASE;

ADULT; AGED; ARTICLE; BAYES THEOREM; BIOLOGICAL MODEL; BLOOD; DIET RESTRICTION; ENZYMOLOGY; ETHNOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETICS; GLUCOSE BLOOD LEVEL; HISPANIC; HUMAN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

ADULT; AGED; AGED, 80 AND OVER; BAYES THEOREM; BLOOD GLUCOSE; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEPTIN; LINKAGE (GENETICS); MALE; METABOLIC SYNDROME X; MEXICAN AMERICANS; MIDDLE AGED; MODELS, GENETIC; OBESITY; PHENOTYPE; PHOSPHORIC DIESTER HYDROLASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PYROPHOSPHATASES; RISK FACTORS; TEXAS;

EID: 46249130010     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.262     Document Type: Article

References (24)

1. Duggirala R, Blangero J, Almasy L et al. A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet 2001;68:1149-1164.
2. Ghosh S, Watanabe RM, Valle TT et al. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 2000;67:1174-1185.
3. Arya R, Lehman D, Hunt KJ, Schneider J et al. Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study. BMC Genet 2003;4(Suppl 1):S52.
4. Atwood LD, Heard-Costa NL, Cupples LA et al. Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet 2002;71:1044-1050.
5. Meyre D, Lecoeur C, Delplanque J et al. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 2004;53:803-811.
6. Pizzuti A, Frittitta L, Argiolas A et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 1999;48:1881-1884.
7. Abate N, Chandalia M, Satija P et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 2005;54:1207-1213.
8. Bacci S, Ludovico O, Prudente S et al. The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction. Diabetes 2005;54:3021-3025.
9. Meyre D, Bouatia-Naji N, Tounian A et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005;37:863-867.
10. Böttcher Y, Körner A, Reinehr T et al. ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children. J Clin Endocrinol Metab 2006;91:4948-4952.
11. Matsuoka N, Patki A, Tiwari HK et al. Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults. Int J Obes (Lond) 2006;30:233-237.
12. Prudente S, Chandalia M, Morini E et al. The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites. Obesity (Silver Spring) 2007;15:1-4.
13. Grarup N, Urhammer SA, Ek J et al. Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects. Diabetologia 2006; 49:2097-2104.
14. Lyon HN, Florez JC, Bersaglieri T et al. Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes 2006;55:3180-3184.
15. Weedon MN, Shields B, Hitman G et al. No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes 2006;55:3175-3179.
16. Bochenski J, Placha G, Wanic K et al. New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes 2006;55:2626-2630.
17. Blangero J. Localization and identification of human quantitative trait loci: king harvest has surely come. Curr Opin Genet Dev 2004;14:233-240.
18. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
19. Blangero J, Goring HH, Kent JW Jr et al. Quantitative trait nucleotide analysis using Bayesian model selection. Hum Biol 2005;77:541-559.
20. Stern MP, Duggirala R, Mitchell BD et al. Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res 1996;6:724-734.
21. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211.
22. Abecasis GR, Cookson WO, Cardon LR. Pedigree tests of transmission disequilibrium. Eur J Hum Genet 2000;8:545-551.
23. Almasy L, Blangero J. Exploring positional candidate genes: linkage conditional on measured genotype. Behav Genet 2004;34:173-177.
24. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.