Effects of cytochrome P450 (CYP) inducers and inhibitors on ondansetron pharmacokinetics in rats: Involvement of hepatic CYP2D subfamily and 3A1/2 in ondansetron metabolism

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 7, 2008, Pages 853-861

  Yang, Si H ^a   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C6; CYTOCHROME P450 2D; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DEXAMETHASONE SODIUM PHOSPHATE; ISOENZYME; ISONIAZID; ONDANSETRON; ORPHENADRINE CITRATE; PROADIFEN; QUININE; SULFAPHENAZOLE; TROLEANDOMYCIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; IN VIVO STUDY; LIVER; LIVER MICROSOME; MALE; NONHUMAN; RAT; STATISTICAL ANALYSIS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOOD PROTEINS; CYTOCHROME P-450 CYP2D6; ENZYME INDUCTION; ENZYME INHIBITORS; LIVER; MALE; MEMBRANE PROTEINS; ONDANSETRON; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 46249117040     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.7.0006     Document Type: Article

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