Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 7, 2008, Pages 2667-2672

  Boyd, David A ^a   Willey, Barbara M ^b   Fawcett, Darlene ^c   Gillani, Nazira ^c   Mulvey, Michael R ^a,d  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c Rouge Valley Health Centre Centenary Site   (Canada)

^d PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GENE PRODUCT; PROTEIN VANT; RACEMASE; SERINE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; DNA SEQUENCE; ENTEROCOCCUS FAECALIS; GENE CLUSTER; MEMBRANE BINDING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRIORITY JOURNAL; VANC GENE; VANL GENE; VANTM GENE; VANTR GENE;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE COMPOSITION; BASE SEQUENCE; DNA PRIMERS; DNA, BACTERIAL; ENTEROCOCCUS FAECALIS; GENES, BACTERIAL; HUMANS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPERON; PEPTIDE SYNTHASES; SEQUENCE HOMOLOGY, AMINO ACID; VANCOMYCIN RESISTANCE;

EID: 46249111916     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01516-07     Document Type: Article

References (22)

1. Arias, C. A., P. Courvalin, and P. E. Reynolds. 2000. vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174. Antimicrob. Agents Chemother. 46:95-100.
2. Arias, C. A., M. Martin-Martinez, T. L. Blundell, M. Arthur, P. Courvalin, and P. E. Reynolds. 1999. Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174. Mol. Microbiol. 31:1653-1664.
3. Arias, C. A., J. Peña, D. Panesso, and P. Reynolds. 2003. Role of the transmembrane domain of the VanT serine racemase in resistance to vancomycin in Enterococcus gallinarum BM4174. J. Antimicrob. Chemother. 51:557-564.
4. Arthur, M., C. Molinas, and P. Courvalin. 1992. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 173:2582-2591.
5. Boyd, D. A., T. Cabral, P. Van Caseele, J. Wylie, and M. R. Mulvey. 2002. Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada. Antimicrob. Agents Chemother. 46:1977-1979.
6. Boyd, D. A., T. Du, R. Hizon, B. Kaplen, T. Murphy, S. Tyler, S. Brown, F. Jamieson, K. Weiss, M. R. Mulvey, et al. 2006. VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada. Antimicrob. Agents Chemother. 50:2217-2221.
7. Boyd, D. A., P. Kibsey, D. Roscoe, and M. R. Mulvey. 2004. Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon. J. Antimicrob. Chemother. 54:680-683.
8. Clark, N. C., R. C. Cooksey, B. C. Hill, J. M. Swenson, and F. Tenover. 1993. Characterization of glycopeptide-resistant enterococci from U.S. hospitals. Antimicrob. Agents Chemother. 37:2311-2317.
9. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow acrobically, 7th ed. Approved standard M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.
10. Depardieu, F., M. G. Bonora, P. E. Reynolds, and P. Courvalin. 2003. The vanG glycopeptide resistance operon from Enterococcus faecalis revisited. Mol. Microbiol. 50:931-948.
11. Dukta-Malen, S., S. Evers, and P. Courvalin. 1995. Detection of glycopeptides resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J. Clin. Microbiol. 33:24-27.
12. Elsayed, S., N. Hamilton, D. Boyd, and M. Mulvey. 2001. Improved primer design for multiplex PCR analysis of vancomycin-resistant Enterococcus spp. J. Clin. Microbiol. 39:2367-2368.
13. Evers, S., B. Casadewall, M. Charles, S. Dutka-Malen, M. Galimand, and P. Courvalin. 1996. Evolution of structure and substrate specificity in D-alanine:D-alanine ligases and related enzymes. J. Mol. Evol. 42:706-712.
14. Fines, M., B. Périchon, P. Reynolds, D. F. Sahm, and P. Courvalin. 1999. VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405. Antimicrob. Agents Chemother. 43:2161-2164.
15. Gold, H. S., S. Unal, E. Cercenado, C. Thauvin-Eliopoulos, G. M. Eliopoulos, C. B. Wennersten, and R. C. Moellering, Jr. 1993. A gene conferring resistance to vancomycin but not teicoplanin in isolates of Enterococcus faecalis and Enterococcus faecium demonstrates homology with vanB, vanA, and vanC genes of enterococci. Antimicrob. Agents Chemother. 37:1604-1609.
16. Hsing, W., F. D. Russo, K. K. Bernd, and T. J. Silhavy. 1998. Mutations that alter kinase and phosphatase activities of the two-component sensor EnvZ. J. Bacteriol. 180:4538-4546.
17. Mahillon, J., and M. Chandler. 1998. Insertion sequences. Microbiol. Mol. Biol. Rev. 62:725-774.
18. Msadek, T., F. Knust, and G. Rapopport. 1993. Two-component regulatory systems, p. 729-745. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, DC.
19. Panesso, D., L. Abadía-Patiño, N. Vanegas, P. E. Reynolds, P. Courvalin, and C. A. Arias. 2005. Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance. Antimicrob. Agents Chemother. 49:1060-1066.
20. C encodes D,D-dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174. Mol. Microbiol. 34:341-349.
21. Reynolds, P. E., and P. Courvalin. 2005. Vancomycin resistance in enterococci due to synthesis of precursors terminating in D-alanyl- D-serine. Antimicrob. Agents Chemother. 49:21-25.
22. Singer, T., and E. Burke. 2003. High-throughput TAIL-PCR as a tool to identify DNA flanking insertions. Methods Mol. Biol. 236:241-271.