Mutations that alter the kinase and phosphatase activities of the two- component sensor EnvZ

Journal of Bacteriology

Volumn 180, Issue 17, 1998, Pages 4538-4546

  Hsing, Weihong ^a,b   Russo, Frank D ^a,c   Bernd, Karen K ^a,d   Silhavy, Thomas J ^a  

^a PRINCETON UNIVERSITY   (United States)

^b Small Molecule Therapeutics   (United States)

^c Incyte Pharmaceuticals ^*  (United States)

^d DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; ENVZ PROTEIN; MEMBRANE RECEPTOR; OUTER MEMBRANE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PORIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE MUTATION; NONHUMAN; OSMOREGULATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SENSOR; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0031782823     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.180.17.4538-4546.1998     Document Type: Article

References (28)

1. Atkinson, M. R., and A. J. Ninfa. 1992. Characterization of Escherichia coli glnL mutations affecting nitrogen regulation. J. Bacteriol. 174:4538-4548.
2. Casadaban, M. J. 1976. Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage Lambda and Mu. J. Mol. Biol. 104:541-555.
3. Chiang, R. C., R. Cavicchioli, and R. P. Gunsalus. 1992. Identification and characterization of narQ, a second nitrate sensor for nitrate-dependent gene regulation in Escherichia coli. Mol. Microbiol. 6:1913-1923.
4. Forst, S., and M. Inouye. 1988. Environmentally regulated gene expression for membrane proteins in Escherichia coli. Annu. Rev. Cell. Biol. 4:21-42.
5. Grebe, T., and J. B. Stock. Personal communication.
6. Hall, M. N., and T. J. Silhavy. 1979. Transcriptional regulation at Escherichia coli K-12 major outer membrane protein 1b. J. Bacteriol. 140:342-350.
7. Hall, M. N., and T. J. Silhavy. 1981. The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12. J. Mol. Biol. 146:23-43.
8. Hamilton, C. M., M. Aldea, B. K. Washburn, P. Babitzke, and S. R. Kushner. 1989. New method for generating deletions and gene replacements in Escherichia coli. J. Bacteriol. 171:4617-4622.
9. Hoch, J. A., and T. J. Silhavy. 1995. Two-component signal transduction. American Society for Microbiology, Washington, D.C.
10. Hsing, W., and T. J. Silhavy. 1997. Function of conserved histidine-243 in phosphatase activity of EnvZ, the sensor for porin osmoregulation in Escherichia coli. J. Bacteriol. 179:3729-3735.
11. Huang, K., and M. M. Igo. 1996. Identification of the bases in the ompF regulatory region, which interact with the transcription factor OmpR. J. Mol. Biol. 262:615-628.
12. Igo, M. M., and T. J. Silhavy. 1988. EnvZ, a transmembrane environmental sensor of Escherichia coli K-12, is phosphorylated in vitro. J. Bacteriol. 170:5971-5973
13. Igo, M. M., A. J. Ninfa, and T. J. Silhavy. 1989. A bacterial environmental sensor that functions as a protein kinase and stimulates transcriptional activation. Genes Dev. 3:598-605.
14. Igo, M. M., A. J. Ninfa, J. B. Stock, and T. J. Silhavy. 1989. Phosphorylation and dephosphorylation of a bacterial transcription activator by a transmembrane receptor. Genes Dev. 3:1725-1734.
15. Leonardo, M. R., and S. Forst. 1996. Re-examination of the role of the periplasmic domain of EnvZ in sensing of osmolarity signal in Escherichia coli. Mol. Microbiol. 22:405-415.
16. Mizuno, T., and S. Mizushima. 1990. Signal transduction and gene regulation through the phosphorylation of two regulatory components: the molecular basis for the osmotic regulation of the porin genes. Mol. Microbiol. 4:1077-1082.
17. Ninfa, E. G., M. R. Atkinson, E. S. Kamberov, and A. J. Ninfa. 1993. Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NRII or NtrB): transphosphorylation between subunits. J. Bacteriol. 175: 7024-7031.
18. Parkinson, J. S., and E. C. Kofoid. 1992. Communication modules in bacterial signaling proteins. Annu. Rev. Genet. 26:71-112.
19. Pratt, L. A., and T. J. Silhavy. 1995. Porin regulon of Escherichia coli, p. 105-127. In J. A. Hoch and T. J. Silhavy (ed.), Two-component signal transduction. American Society for Microbiology, Washington, D.C.
20. Rabin, R. S., and V. Stewart. 1992. Either of two functionally redundant sensor proteins, NarX and NarQ, is sufficient for nitrate regulation in Escherichia coli K-12. Proc. Natl. Acad. Sci. USA 89:8419-8423.
21. Rabin, R. S., and V. Stewart. 1995. Dual sensors and dual response regulators interact to control nitrate-and nitrite-responsive gene expression in Escherichia coli, p. 233-252. In J. A. Hoch and T. J. Silhavy (ed.), Two-component signal transduction. American Society for Microbiology, Washington, D.C.
22. Russo, F. D., and T. J. Silhavy. 1991. EnvZ controls the concentration of phosphorylated OmpR to mediate osmoregulation of the porin genes. J. Mol. Biol. 222:567-580.
23. Silhavy, T. J., M. Berman, and L. Enquist. 1984. Experiments with gene fusions. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
24. Slauch, J. M., and T. J. Silhavy. 1989. Genetic analysis of the switch that controls porin gene expression in Escherichia coli K-12. J. Mol. Biol. 210: 281-292.
25. Stock, J. B., M. G. Surette, M. Levit, and P. Park. 1995. Two-component signal transduction systems: structure-function relationships and mechanisms of catalysis, p. 25-51. In J. A. Hoch and T. J. Silhavy (ed.), Two-component signal transduction. American Society for Microbiology, Washington, D.C.
26. Taylor, S. S., D. R. Knighton, J. Zheng, L. F. Ten Eyck, and J. M. Sowadski. 1992. Structural framework for the protein kinase family. Annu. Rev. Cell Biol. 8:429-462.
27. Tokishita, S., and T. Mizuno. 1994. Transmembrane signal transduction by the Escherichia coli osmotic sensor, EnvZ: intermolecular complementation of transmembrane signaling. Mol. Microbiol. 13:435-444.
28. Yang, Y., and M. Inouye. 1993. Requirement of both kinase and phosphatase activities of an Escherichia coli receptor (Taz1) for ligand-dependent signal transduction. J. Mol. Biol. 231:335-342.