Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxicischemic insult in neonatal rodents

Stroke

Volumn 39, Issue 6, 2008, Pages 1862-1868

  Wendland, Michael F ^a   Faustino, Joel ^b   West, Tim ^c   Manabat, Catherine ^b   Holtzman, David M ^c   Vexler, Zinaida S ^b,d  

^a Institute of Radiology   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Caspase 3; Diffusion weighted MRI; Hypoxia ischemia; Neonate

Indexed keywords

CASPASE 3; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; APPARENT DIFFUSION COEFFICIENT; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN VENTRICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FEMALE; HISTOPATHOLOGY; NEONATAL ENCEPHALOPATHY; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; WHITE MATTER; ANIMAL; ANISOTROPY; BRAIN; BRAIN INFARCTION; DISEASE COURSE; DISEASE MODEL; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; METHODOLOGY; MYELINATED NERVE; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ANIMALS, NEWBORN; ANISOTROPY; APOPTOSIS; BIOLOGICAL MARKERS; BRAIN; BRAIN INFARCTION; CASPASE 3; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME ACTIVATION; HYPOXIA-ISCHEMIA, BRAIN; NERVE FIBERS, MYELINATED; NEURONS; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 46249093716     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.506352     Document Type: Article

References (30)

1. Inder TE, Huppi PS. In vivo studies of brain development by magnetic resonance techniques. Ment Retard Dev Disabil Res Rev. 2000;6:59-67.
2. Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351:1985-1995.
3. Dijkhuizen RM, van Lookeren Campagne M, Niendorf T, Dreher W, van der Toorn A, Hoehn-Berlage M, Verheul HB, Tulleken CA, Leibfritz D, Hossmann KA, Nicolay K. Status of the neonatal rat brain after NMDA-induced excitotoxic injury as measured by MRI, MRS and metabolic imaging. NMR Biomed. 1996;9:84-92.
4. Dijkhuizen RM, Knollema S, van der Worp HB, Ter Horst GJ, De Wildt DJ, Berkelbach van der Sprenkel JW, Tulleken KA, Nicolay K. Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. Stroke. 1998;29:695-704.
5. Tuor UI, Kozlowski P, Del Bigio MR, Ramjiawan B, Su S, Malisza K, Saunders JK. Diffusion- and T2-weighted increases in magnetic resonance images of immature brain during hypoxia-ischemia: transient reversal posthypoxia. Exp Neurol. 1998;150:321-328.
6. Derugin N, Wendland M, Muramatsu K, Roberts T, Gregory G, Ferriero D, Vexler Z. Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rat. Stroke. 2000;31:1752-1761.
7. Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM, Vexler ZS. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke. 2003;34:207-213.
8. van Bruggen N, Cullen BM, King MD, Doran M, Williams SR, Gadian DG, Cremer JE. T2- and diffusion-weighted magnetic resonance imaging of a focal ischemic lesion in rat brain. Stroke. 1992;23:576-582.
9. Ashwal S, Tone B, Tian HR, Chong S, Obenaus A. Comparison of two neonatal ischemic injury models using magnetic resonance imaging. Pediatr Res. 2007;61:9-14.
10. Derugin N, Dingman A, Wendland M, Fox C, Vexler ZS. Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model. Brain Res. 2005;1066:49-56.
11. Wang Y, Cheung PT, Shen GX, Wu EX, Cao G, Bart I, Wong WH, Khong PL. Hypoxic-ischemic brain injury in the neonatal rat model: Relationship between lesion size at early MR imaging and irreversible infarction. AJNR Am J Neuroradiol. 2006;27:51-54.
12. Rumpel H, Nedelcu J, Aguzzi A, Martin E. Late glial swelling after acute cerebral hypoxia-ischemia in the neonatal rat: a combined magnetic resonance and histochemical study. Pediatr Res. 1997;42:54-59.
13. Qiao M, Malisza KL, Del Bigio MR, Tuor UI. Transient hypoxia-ischemia in rats: changes in diffusion-sensitive MR imaging findings, extracellular space, and Na+-K +-adenosine triphosphatase and cytochrome oxidase activity. Radiology. 2002;223:65-75.
14. Cheng Y, Gidday JM, Yan Q, Shah AR, Holtzman DM. Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury. Ann Neurol. 1997;41:521-529.
15. Hu BR, Liu CL, Ouyang Y, Blomgren K, Siesjo BK. Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation. J Cereb Blood Flow Metab. 2000;20:1294-1300.
16. Han BH, Holtzman DM. BDNF protects the neonatal brain from hypoxi-c-ischemic injury in vivo via the ERK pathway. J Neurosci. 2000;20: 5775-5781.
17. Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vail-lancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death following neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002;277: 30128-30136.
18. Fox C, Dingman A, Derugin N, Wendland MF, Manabat C, Ji S, Ferriero DM, Vexler ZS. Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 2005;25:1138-1149.
19. Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS. Aminogua-nidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient ischemia. J Neurochem. 2006;96:1467-1479.
20. Blomgren K. Calpastatin is upregulated and acts as a suicide substrate to calpains in neonatal rat hypoxia-ischemia. Ann N Y Acad Sci. 1999;890: 270-271.
21. Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony JA, Aronow BJ, Holtzman DM. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nat Med. 2001;7:338-343.
22. Matsumori Y, Northington F, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Reduction of caspase-9 cleavage is associated with increased binding of APAF-1 and HSP70 after neonatal hypoxic/ischemic injury in mice over-expressing HSP70. Stroke. 2006; 37:507-512.
23. Cheng Y, Deshmukh M, D'Costa A, Demaro JA, Gidday JM, Shah A, Sun Y, Jacquin MF, Johnson EM, Holtzman DM. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest. 1998;101: 1992-1999.
24. Dijkhuizen RM, de Graaf RA, Tulleken KA, Nicolay K. Changes in the diffusion of water and intracellular metabolites after excitotoxic injury and global ischemia in neonatal rat brain. J Cereb Blood Flow Metab. 1999;19:341-349.
25. Ashwal S, Tone B, Tian HR, Chong S, Obenaus A. Serial magnetic resonance imaging in a rat pup filament stroke model. Exp Neurol. 2006;202:294-301.
26. Ringer TM, Neumann-Haefelin T, Sobel RA, Moseley ME, Yenari MA. Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia. Stroke. 2001;32:2362-2369.
27. Hedtjarn M, Mallard C, Hagberg H. Inflammatory gene profiling in the developing mouse brain after hypoxia-ischemia. J Cereb Blood Flow Metab. 2004;24:1333-1351.
28. Siesjo BK. Pathophysiology and treatment of focal cerebral ischemia. Part I: pathophysiology. J Neurosurg. 1992;77:169-184.
29. Northington FJ, Graham EM, Martin LJ. Apoptosis in perinatal hypoxi-c-ischemic brain injury: how important is it and should it be inhibited? Brain Res Brain Res Rev. 2005;50:244-257.
30. Hagberg H, Mallard C. Effect of inflammation on central nervous system development and vulnerability. Curr Opin Neurol. 2005;18:117-123.