Hypoxic-ischemic brain injury in the neonatal rat model: Relationship between lesion size at early MR imaging and irreversible infarction

American Journal of Neuroradiology

Volumn 27, Issue 1, 2006, Pages 51-54

  Wang, Y ^a   Cheung, P T ^a   Shen, G X ^a   Wu, E X ^a   Cao, G ^b   Bart, I ^a   Wong, W H S ^a   Khong, Pek Lan ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b GE Medical Systems   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BRAIN HYPOXIA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; COMMON CAROTID ARTERY; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FEMALE; HISTOPATHOLOGY; IMAGE ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; ANIMAL; BRAIN; BRAIN INFARCTION; NEWBORN; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CEREBRAL INFARCTION; DIFFUSION MAGNETIC RESONANCE IMAGING; HYPOXIA-ISCHEMIA, BRAIN; MAGNETIC RESONANCE IMAGING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33644868837     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection. Ment Retard Dev Disabil Res Rev 2001;7:56-64
2. Adcock KH, Nedelcu J, Loenneker T, et al. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. Dev Neurosci 2002;24:382-88
3. Lee JH, Lee YK, Ishikawa M, et al. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats-an MRI study. Brain Res 2003;994:91-98
4. Petty MA, Neumann-Haefelin C, Kalisch J, et al. In vivo neuroprotective effects of ACEA 1021 confirmed by magnetic resonance imaging in ischemic stroke. Eur J Pharmacol 2003;474:53-62
5. Johnston MV, Trescher WH, Ishida A, et al. Novel treatments after experimental brain injury. Semin Neonatol 2000;5:75-86
6. Nedelcu J, Klein MA, Aguzzi A, et al. Resuscitative hypothermia protects the neonatal rat brain from hypoxic-ischemic injury. Brain Pathol 2000;10:61-71
7. Wagner BP, Nedelcu J, Martin E. Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats. Pediatr Res 2002;51:354-60
8. Williams GD, Dardzinski BJ, Buckalew AR, et al. Modest hypothermia preserves cerebral energy metabolism during hypoxia-ischemia and correlates with brain damage: a 31P nuclear magnetic resonance study in unanesthetized neonatal rats. Pediatr Res 1997;42:700-708
9. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;19:365:663-70
10. Hagberg H, Bona E, Gilland E, et al. Hypoxia-ischaemia model in the 7-day-old rat: possibilities and shortcomings. Acta Paediatr Suppl 1997;422:85-88
11. Hagberg H, Ichord R, Palmer C, et al. Animal models of developmental brain injury: relevance to human disease: a summary of the panel discussion from the Third Hershey Conference on Developmental Cerebral Blood Flow and Metabolism. Dev Neurosci 2002;24:364-66
12. Vannucci RC, Connor JR, Mauger DT, et al. Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res 1999;55:158-63
13. Roohey T, Raju TN, Moustogiannis AN. Animal models for the study of perinatal hypoxic-ischemic encephalopathy: a critical analysis. Early Hum Dev 1997;47:115-46
14. Qiao M, Malisza KL, Del Bigio MR, et al. Transient hypoxia-ischemia in rats: changes in diffusion-sensitive MR imaging findings, extracellular space, and Na+-K+ -adenosine triphosphatase and cytochrome oxidase activity. Radiology 2002;223:65-75
15. Ringer TM, Neumann-Haefelin T, Sobel RA, et al. Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia. Stroke 2001;32:2362-69
16. Lythgoe MF, Thomas DL, Calamante F, et al. Acute changes in MRI diffusion, perfusion, T(1), and T(2) in a rat model of oligemia produced by partial occlusion of the middle cerebral artery. Magn Reson Med 2000;44:706-12
17. Ordidge R, Thornton J, Clemence M, et al. NMR studies of hypoxic-ischaemic injury in neonatal brain using imaging and spectroscopy. Adv Exp Med Biol 1997;428:539-44
18. Tuor UI, Kozlowski P, Del Bigio MR, et al. Diffusion- and T2-weighted increases in magnetic resonance images of immature brain during hypoxia-ischemia: transient reversal posthypoxia. Exp Neurol 1998;150:321-28
19. Nedelcu J, Klein MA, Aguzzi A, et al. Biphasic edema after hypoxic-ischemic brain injury in neonatal rats reflects early neuronal and late glial damage. Pediatr Res 1999;46:297-304
20. Miyasaka N, Nagaoka T, Kuroiwa T, et al. Histopathologic correlates of temporal diffusion changes in a rat model of cerebral hypoxia/ischemia. AJNR Am J Neuroradiol 2000;21:60-66
21. Rumpel H, Nedelcu J, Aguzzi A, et al. Late glial swelling after acute cerebral hypoxia-ischemia in the neonatal rat: a combined magnetic resonance and histochemical study. Pediatr Res 1997;42:54-59
22. Miyasaka N, Kuroiwa T, Zhao FY, et al. Cerebral ischemic hypoxia: discrepancy between apparent diffusion coefficients and histologic changes in rats. Radiology 2000;215:199-204
23. Ning G, Malisza KL, Del Bigio MR, et al. Magnetic resonance imaging during cerebral hypoxia-ischemia: T2 increases in 2-week-old but not 4-week-old rats. Pediatr Res 1999;45:173-79
24. Olah L, Wecker S, Hoehn M. Secondary deterioration of apparent diffusion coefficient after 1-hour transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000;20:1474-82
25. Iadecola C, Zhang F, Xu X. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 1995;268:R286-92
26. McRae A, Gilland E, Bona E, et al. Microglia activation after neonatal hypoxic-ischemia. Brain Res Dev Brain Res 1995;84:245-52
27. Olah L, Wecker S, Hoehn M. Relation of apparent diffusion coefficient changes and metabolic disturbances after 1 hour of focal cerebral ischemia and at different reperfusion phases in rats. J Cereb Blood Flow Metab 2001;21: 430-39
28. Hoehn-Berlage M, Norris DG, Kohno K, et al. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab 1995;15:1002-11