Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production

Vaccine

Volumn 26, Issue 31, 2008, Pages 3897-3902

  Elias, Daniel ^a,b   Britton, Sven ^b   Aseffa, Abraham ^a   Engers, Howard ^a   Akuffo, Hannah ^b  

^a ARMAUER HANSEN RESEARCH INSTITUTE   (Ethiopia)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

BCG; Helminths; TGF ; Tuberculosis

Indexed keywords

ALBENDAZOLE; BCG VACCINE; CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; MYCOBACTERIUM ANTIGEN; PLACEBO; TRANSFORMING GROWTH FACTOR BETA; TUBERCULIN;

ADOLESCENT; ADULT; ARTICLE; BCG VACCINATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HELMINTHIASIS; HUMAN; IMMUNOGENICITY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MYCOBACTERIOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PREVALENCE; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL; TUBERCULIN TEST; TUBERCULOSIS;

ADOLESCENT; ADULT; ANIMALS; ANTHELMINTICS; CELLS, CULTURED; HELMINTHIASIS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; MYCOBACTERIUM BOVIS; PLACEBOS; TRANSFORMING GROWTH FACTOR BETA; TUBERCULOSIS VACCINES;

EID: 46149094837     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.04.083     Document Type: Article

References (33)

1. Trunz B.B., Fine P., and Dye C. Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367 (2006) 1173-1180
2. Fine P.E. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 346 (1995) 1339-1345
3. Flaherty D.K., Vesosky B., Beamer G.L., Stromberg P., and Turner J. Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination. J Leukoc Biol (2006)
4. Black G.F., Dockrell H.M., Crampin A.C., Floyd S., Weir R.E., Bliss L., et al. Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi. J Infect Dis 184 (2001) 322-329
5. Brown C.A., Brown I.N., and Swinburne S. The effect of oral Mycobacterium vaccae on subsequent responses of mice to BCG sensitisation. Tubercle 66 (1985) 251-260
6. Palmer C.E., and Long M.W. Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis. Am Rev Respir Dis 94 (1966) 553-568
7. Colditz G.A., Brewer T.F., Berkey C.S., Wilson M.E., Burdick E., Fineberg H.V., et al. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA 271 (1994) 698-702
8. Hori H., Watanabe M., and Sakurai M. Infectious diseases in African children. Acta Paediatr Jpn 35 (1993) 553-558
9. Chan M.S. The global burden of intestinal nematode infections--fifty years on. Parasitol Today 13 (1997) 438-443
10. Kullberg M.C., Pearce E.J., Hieny S.E., Sher A., and Berzofsky J.A. Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen. J Immunol 148 (1992) 3264-3270
11. Borkow G., Leng Q., Weisman Z., Stein M., Galai N., Kalinkovich A., et al. Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy. J Clin Invest 106 (2000) 1053-1060
12. Hoerauf A., Satoguina J., Saeftel M., and Specht S. Immunomodulation by filarial nematodes. Parasite Immunol 27 (2005) 417-429
13. Stewart G.R., Boussinesq M., Coulson T., Elson L., Nutman T., and Bradley J.E. Onchocerciasis modulates the immune response to mycobacterial antigens. Clin Exp Immunol 117 (1999) 517-523
14. Leng Q., Bentwich Z., and Borkow G. Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activation. Int Immunol 18 (2006) 637-644
15. Babu S., Blauvelt C.P., Kumaraswami V., and Nutman T.B. Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. J Immunol 176 (2006) 3248-3256
16. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101 (2000) 455-458
17. Iwashiro M., Messer R.J., Peterson K.E., Stromnes I.M., Sugie T., and Hasenkrug K.J. Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc Natl Acad Sci USA 98 (2001) 9226-9230
18. McGuirk P., McCann C., and Mills K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 195 (2002) 221-231
19. Hesse M., Piccirillo C.A., Belkaid Y., Prufer J., Mentink-Kane M., Leusink M., et al. The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J Immunol 172 (2004) 3157-3166
20. Satoguina J., Mempel M., Larbi J., Badusche M., Loliger C., Adjei O., et al. Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis). Microbes Infect 4 (2002) 1291-1300
21. McKee A.S., and Pearce E.J. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173 (2004) 1224-1231
22. Elias D., Wolday D., Akuffo H., Petros B., Bronner U., and Britton S. Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guerin (BCG) vaccination. Clin Exp Immunol 123 (2001) 219-225
23. Elias D., Akuffo H., Pawlowski A., Haile M., Schon T., and Britton S. Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis. Vaccine 23 (2005) 1326-1334
24. Elias D., Akuffo H., Thors C., Pawlowski A., and Britton S. Low dose chronic Schistosoma mansoni infection increases susceptibility to Mycobacterium bovis BCG infection in mice. Clin Exp Immunol 139 (2005) 398-404
25. Pai M., Gokhale K., Joshi R., Dogra S., Kalantri S., Mendiratta D.K., et al. Mycobacterium tuberculosis infection in health care workers in rural India: comparison of a whole-blood interferon gamma assay with tuberculin skin testing. JAMA 293 (2005) 2746-2755
26. Sokal J.E. Editorial: measurement of delayed skin-test responses. N Engl J Med 293 (1975) 501-502
27. Sleigh A., Hoff R., Mott K., Barreto M., de Paiva T.M., Pedrosa Jde S., et al. Comparison of filtration staining (Bell) and thick smear (Kato) for the detection of quantitation of Schistosoma mansoni eggs in faeces. Trans R Soc Trop Med Hyg 76 (1982) 403-406
28. Resende Co T., Hirsch C.S., Toossi Z., Dietze R., and Ribeiro-Rodrigues R. Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy. Clin Exp Immunol 147 (2007) 45-52
29. McElroy M.D., Elrefaei M., Jones N., Ssali F., Mugyenyi P., Barugahare B., et al. Coinfection with Schistosoma mansoni is associated with decreased HIV-specific cytolysis and increased IL-10 production. J Immunol 174 (2005) 5119-5123
30. Mahanty S., Mollis S.N., Ravichandran M., Abrams J.S., Kumaraswami V., Jayaraman K., et al. High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis. J Infect Dis 173 (1996) 769-773
31. Doetze A., Satoguina J., Burchard G., Rau T., Loliger C., Fleischer B., et al. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift. Int Immunol 12 (2000) 623-630
32. Moreno S., Blazquez R., Novoa A., Carpena I., Menasalvas A., Ramirez C., et al. The effect of BCG vaccination on tuberculin reactivity and the booster effect among hospital employees. Arch Intern Med 161 (2001) 1760-1765
33. Roth A., Sodemann M., Jensen H., Poulsen A., Gustafson P., Gomes J., et al. Vaccination technique, PPD reaction and BCG scarring in a cohort of children born in Guinea-Bissau 2000-2002. Vaccine 23 (2005) 3991-3998