High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis

Journal of Infectious Diseases

Volumn 173, Issue 3, 1996, Pages 769-773

  Mahanty, Siddhartha ^a   Mollis, Stacey N ^b   Ravichandran, Manickam ^d   Abrams, John S ^d   Kumaraswami, V ^d   Jayaraman, Kunthala ^d   Ottesen, Eric A ^c   Nutman, Thomas B ^d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 5; INTERLEUKIN 6; PARASITE ANTIGEN; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ANTIGEN SPECIFICITY; ARTICLE; BRUGIA MALAYI; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LYMPHATIC SYSTEM INFECTION; LYMPHOCYTE PROLIFERATION; MALE; MICROFILARIASIS; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; WUCHERERIA BANCROFTI;

EID: 0030021935     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.3.769     Document Type: Article

References (5)

1. Yazdanbakhsh M, Paxton WA, Knuize YC, et al. T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis. J Infect Dis 1993;167:925-31.
2. King CL, Mahanty S, Kumaraswami V, et al. Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. J Clin Invest 1993;92:1667-73.
3. Hussain R, Hamilton R, Kumarawami V, Adkinson NF Jr, Ottesen EA. IgE responses in human filariasis. I. Quantitaten of filaria-specific IgE. J Immunol 1981;127:1623-30.
4. Mahanty S, Abrams JS, King CL, Limaye AP, Nutman TB. Parallel regulation of IL-4 and IL-5 in human helminth infections. J Immunol 1992:148:3567-71.
5. Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev 1992;127:5-24.