Anti-angiogenic function of tocotrienol

Asia Pacific Journal of Clinical Nutrition

Volumn 17, Issue SUPPL. 1, 2008, Pages 253-256

  Miyazawa, Teruo ^a   Shibata, Akira ^a   Nakagawa, Kiyotaka ^a   Tsuzuki, Tsuyoshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Anti angiogenesis; HUVEC; PI3K; Tocotrienol; Vitamin E

Indexed keywords

ALPHA TOCOTRIENOL; ANGIOGENESIS INHIBITOR; FIBROBLAST GROWTH FACTOR;

ANGIOGENESIS; ANIMAL; ARTICLE; BIOASSAY; CELL CULTURE; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECT; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MOUSE; NEOVASCULARIZATION (PATHOLOGY);

ANGIOGENESIS INHIBITORS; ANIMALS; BIOLOGICAL ASSAY; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTORS; HUMANS; MALE; MICE; MICE, INBRED ICR; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; TOCOTRIENOLS;

EID: 46049095308     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Sundram K, Thiagarajan T, Gapor A, Basiron Y. Palm tocotrienols: New antioxidants for the new millennium. Inform. 2002;13:634-40.
2. Suzuki YJ, Tsuchiya M, Wassall SR, Choo YM, Govil G, Kagan VE, Packer L. Structural and dynamic membrane properties of α-tocopherol and α-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry. 1993;32:10692-9.
3. Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993;268:11230-8.
4. McIntyre BS, Briski KP, Gapor A, Sylvester PW. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med. 2000;224:292-301.
5. Theriault A, Chao JT, Gapor A. Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. Atherosclerosis. 2002;160:21-30.
6. Ahn KS, Sethi G, Krishnan K, Aggarwal BB. γ-Tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem. 2007;282:809-20.
7. Eitsuka T, Nakagawa K, Miyazawa T. Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol. Biochem Biophys Res Commun. 2006;348:170-5.
8. Inokuchi H, Hirokane H, Tsuzuki T, Nakagawa K, Igarashi M, Miyazawa T. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem. 2003;67:1623-7.
9. Nakagawa K, Shibata A, Yamashita S, Tsuzuki T, Kariya J, Oikawa S, Miyazawa T. In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. J Nutr. 2007;137:1938-43.
10. Hsu PP, Li S, Li YS, Usami S, Ratcliffe A, Wang X, Chien S. Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation. Biochem Biophys Res Comm. 2001;285:751-9.
11. Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987;235:442-7.
12. Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE. 1α,25-dihydroxyvitamin D3 inhibits angiogenesis in vitro and in vivo. Circ Res. 2000;87:214-20.
13. Tsuzuki T, Shibata A, Kawakami Y, Nakagawa K, Miyazawa T. Conjugated eicosapentaenoic acid inhibits vascular endothelial growth factor-induced angiogenesis by suppressing the migration of human umbilical vein endothelial cells. J Nutr. 2007;137:641-6.
14. Kawakami Y, Tsuzuki T, Nakagawa K, Miyazawa T. Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. Biosci Biotechnol Biochem. 2007;71:464-71.
15. Traber MG, Packer L. Vitamin E: beyond antioxidant function. Am J Clin Nutr. 1995;62:1501S-9S.