Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Jang, Ji Young ^a   Choi, Yun ^a   Jeon, Yoon Kyung ^a   Aung, Khin Chaw Yu ^a   Kim, Chul Woo ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; CASPASE 3; CASPASE 9; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOFECTAMINE; PROTEIN BAX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GENE THERAPY; CANCER INHIBITION; CELL DAMAGE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; TISSUE DISTRIBUTION; TUMOR REGRESSION; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BREAST TUMOR; CELL GROWTH; DRUG SCREENING; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENINE NUCLEOTIDE TRANSLOCATOR 1; ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; GENE THERAPY; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NF-KAPPA B; SIGNAL TRANSDUCTION; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 45949107070     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-160     Document Type: Article

References (28)

1. Gorczyca W Melamed MR Darzynkiewicz Z Programmed death of cells (apoptosis) Patol Pol 1993, 44:113-119. 8247638
2. van Delft MF Huang DC How the Bcl-2 family of proteins interact to regulate apoptosis Cell Res 2006, 16:203-213. 10.1038/sj.cr.7310028 16474435
3. Cotter TG Lennon SV Glynn JG Martin SJ Cell death via apoptosis and its relationship to growth, development and differentiation of both tumor and normal cells Anticancer Res 1990, 10:1153-1159. 2241096
4. Fulda S Debatin KM Modulation of apoptosis signaling for cancer therapy Arch Immunol Ther Exp (Warsz) 2006, 54:173-175. 10.1007/ s00005-006-0019-x 16652217
5. Klingenberg M Energetic aspects of transport of ADP and ATP through the mitochondrial membrane Ciba Found Symp 1975, 31:105-124. 238804
6. Flierl A Chen Y Coskun PE Samulski RJ Wallace DC Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse Gene Ther 2005, 12:570-578. 1456758 15647764 10.1038/sj.gt.3302443
7. Lunardi J Attardi G Differential regulation of expression of the multiple ADP/ATP translocase genes in human cells J Biol Chem 1991, 266:16534-16540. 1885585
8. Doerner A Pauschinger M Badorff A Noutsias M Giessen S Schulze K Bilger J Rauch U Schultheiss HP Tissue-specific transcription pattern of the adenine nucleotide translocase isoforms in humans FEBS Lett 1997, 414:258-262. 10.1016/S0014-5793(97)01000-4 9315697
9. Bauer MK Schubert A Rocks O Grimm S Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis J Cell Biol 1999, 147:1493-1502. 2174250 10613907 10.1083/ jcb.147.7.1493
10. Halestrap AP Mitochondrial permeability: Dual role for the ADP/ATP translocator? Nature 2004, 430:983-984. 10.1038/nature02816 15329711
11. Chevrollier A Loiseau D Chabi B Renier G Douay O Malthiery Y Stepien G ANT2 isoform required for cancer cell glycolysis J Bioenerg Biomembr 2005, 37:307-316. 10.1007/s10863-005-8642-5 16341775
12. Zamora M Merono C Vinas O Mampel T Recruitment of NF-kappaB into mitochondria is involved in adenine nucleotide translocase (ANT1)-induced apoptosis J Biol Chem 2004, 279:38415-38423. 10.1074/ jbc.M404928200 15231833
13. Hu MC Hung MC Role of IkappaB kinase in tumorigenesis Future Oncol 2005, 1:67-78. 10.1517/14796694.1.1.67 16555977
14. Haefner B Targeting NF-kappaB in anticancer adjunctive chemotherapy Cancer Treat Res 2006, 130:219-245. 16610710
15. Karin M NF-kappaB and cancer: Mechanisms and targets Mol Carcinog 2006, 45:355-361. 10.1002/mc.20217 16673382
16. Janek P Briand P Ian man I The effect of estrone-progesterone treatment on cell proliferation kinetics of hormone-dependent GR mouse mammary tumors Cancer Res 1975, 35:3698-3704. 1192428
17. Green DR Kroemer G The pathophysiology of mitochondrial cell death Science 2004, 305:626-629. 10.1126/science.1099320 15286356
18. Galluzzi L Larochette N Zamzami N Kroemer G Mitochondria as therapeutic targets for cancer chemotherapy Oncogene 2006, 25:4812-4830. 10.1038/ sj.onc.1209598 16892093
19. Green DR Kroemer G Pharmacological manipulation of cell death: Clinical applications in sight? J Clin Invest 2005, 115:2610-2617. 1236695 16200193 10.1172/JCI26321
20. Ferri KF Kroemer G Mitochondria-the suicide organelles Bioessays 2001, 23:111-115. 10.1002/ 1521-1878(200102)23:2<111::AID-BIES1016>3.0.CO;2-Y 11169582
21. Patterson S Spahr CS Daugas E Susin SA Irinopoulou T Koehler C Kroemer G Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition Cell Death Differ 2000, 7:137-144. 10.1038/sj.cdd.4400640 10713728
22. Halestrap AP McStay GP Clarke SJ The permeability transition pore complex: Another view Biochimie 2002, 84:153-166. 10.1016/ S0300-9084(02)01375-5 12022946
23. Vyssokikh MY Brdiczka D The function of complexes between the outer mitochondrial membrane pore (VDAC) and the adenine nucleotide translocase in regulation of energy metabolism and apoptosis Acta Biochim Pol 2003, 50:389-404. 12833165
24. Marzo I Brenner C Zamzami N Jurgensmeier JM Susin SA Vieira HL Prevost MC Xie Z Matsuyama S Reed JC Kroemer G Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis Science 1998, 281:2027-2031. 10.1126/science.281.5385.2027 9748162
25. Belzacq AS Vieira HL Verrier F Vandecasteele G Cohen I Prévost MC Larquet E Pariselli F Petit PX Kahn A Rizzuto R Brenner C Kroemer G Bcl-2 and Bax modulate adenine nucleotide translocase activity Cancer Res 2003, 63:541-546. 12543814
26. Zamora M Ortega JA Alaña L Viñas O Mempel T Apoptotic and anti-proliferative effects of all-trans retionic acid. Adenine nucleotide translocase sensitize HeLa cell to all-trans retionic acid Exp Cell Res 2006, 312:1813-1819. 10.1016/j.yexcr.2006.02.014 16556444
27. Le Bras M Borgne-Sanchez A Touat Z El Dein OS Deniaud A Maillier E Lecellier G Rebouillat D Lemaire C Kroemer G Jacotot E Brenner C Chemosensitization by knockdown of adenine nucleotide translocase-2 Cancer Res 2006, 66:9143-9152. 10.1158/0008-5472.CAN-05-4407 16982757
28. Du ZY Qin RY Xia W Tian R Kumar M Gene transfer of somatostatin receptor type 2 by intratumoral injection inhibits established pancreatic carcinoma xenografts World J Gastroenterol 2005, 11:516-520. 15641137