Infrequent and low AIRE expression in thymoma: Difference in AIRE expression among WHO subtypes does not correlate with association of MG

Autoimmunity

Volumn 41, Issue 5, 2008, Pages 377-382

  Suzuki, Eriko ^a   Kobayashi, Yoshihiro ^a   Yano, Motoki ^a   Fujii, Yoshitaka ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

AIRE; Anti acetylcholine receptor antibody; MG; Thymoma; WHO subtypes

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CHOLINERGIC RECEPTOR ANTIBODY; CYTOKERATIN 13; MESSENGER RNA;

ADULT; AGED; ANTIGEN PRESENTATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HUMAN; MALE; MYASTHENIA GRAVIS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMOMA; WORLD HEALTH ORGANIZATION;

ADULT; AGED; AGED, 80 AND OVER; CHILD, PRESCHOOL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMANS; INFANT; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; RECEPTORS, CHOLINERGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMOMA; THYMUS GLAND; THYMUS NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 45949106831     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930801987573     Document Type: Article

References (21)

1. Zuklys, S., Balciunaite, G., Agarwal, A., Fasler-Kan, E., Palmer, E. and Hollander, GA (2000) Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune polyendocrinopathy candidiasis-ectodermal dystrophy (APECED). J Immunol, 165, pp. 1976-1983.
2. Halonen, M., Pelto-Huikko, M., Eskelin, P., Peltonen, L., Ulmanen, I. and Kolmer, M. (2001) Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendoctrinopathy candidiasis ectodermal dystrophy (APECED). J Hisitochem Cytochem, 49, pp. 197-208.
3. Heino, M., Peterson, P., Kudoh, J., Nagamine, K., Lagerstedt, A., Ovod, V., Ranki, A., Rantala, I., Nieminen, M., Tuukkanen, J., Scott, HS, Antonarakis, SE, Shimizu, N. and Krohn, K. (1999) Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem Biophys Res Commun, 257, pp. 821-825.
4. Aaltonen, J., Bjorses, P., Sandkuijl, L., Perheentupa, J. and Peltonen, L. (1994) An autosomal locus causing autoimmune disease: Autoimmune polyglandular disease type I assigned to chromosome 21. Nat Genet, 8, pp. 83-87.
5. Ramsey, C., Winqvist, O., Puhakka, L., Halonen, M., Moro, A., Kampe, O., Eskelin, P., Pelto-Huikko, M. and Peltonen, L. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet, 11, pp. 397-409.
6. Anderson, MS, Venanzi, ES, Klein, L., Chen, Z., Berzins, SP, Turley, SJ, von Boehmer, H., Bronson, R., Dierich, A., Benoist, C. and Mathis, D. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science, 298, pp. 1395-1401.
7. Eisenbarth, GS and Gottieb, PA (2004) Autoimmune polyendocrine syndromes. N Engl J Med, 350, pp. 2068-2079.
8. Ahonen, P., Myllarniemi, S., Sipila, I. and Perheentupa, J. (1990) Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med, 322, pp. 1829-1836.
9. Egwuagu, CE, Charukamnoetkanok, P. and Gery, I. (1997) Thymic expression of autoantigens correlates with resistance to autoimmune disease. J Immunol, 159, pp. 3109-3112.
10. Hanahan, D. (1998) Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity. Curr Opin Immunol, 10, pp. 656-662.
11. Heath, VL, Moore, NC, Parnell, SM and Mason, DW (1998) Intrathymic expression of genes involved in organ specific autoimmune disease. J Autoimmun, 11, pp. 309-318.
12. Werdelin, O., Cordes, U. and Jensen, T. (1998) Aberrant expression of tissue-specific proteins in the thymus: A hypothesis for the development of central tolerance. Scand J Immunol, 47, pp. 95-100.
13. Johonnidis, JB, Venanzi, ES, Taxman, DJ, Ting, JP, Benoist, CO and Mathis, DJ (2005) Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci USA, 102, pp. 7233-7238.
14. Derbinski, J., Schulte, A., Kyewski, B. and Klein, L. (2001) Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol, 2, pp. 1032-1039.
15. Derbinski, J., Gabler, J., Brors, B., Tierling, S., Jonnakuty, S., Hergenhahn, M., Peltonen, L., Walter, J. and Kyewski, B. (2005) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med, 202, pp. 33-45.
16. Laufer, TM, Glimcher, LH and Lo, D. (1999) Using thymus anatomy to dissect T cell repertoire selection. Semin Immunol, 11, pp. 65-70.
17. Boehm, T., Scheu, S., Pfeffer, K. and Bleul, CC (2003) Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbR. J Exp Med, 198, pp. 757-769.
18. Okumura, M., Ohta, M., Tanaka, H., Nakagawa, K., Matsumura, A., Maeda, H., Tada, H., Eimoto, T., Matsuda, H. and Masaoka, A. (2002) The World Health Organization Histologic Classification System reflects the oncologic behavior of thymoma. Cancer, 94, pp. 624-631.
19. Kondo, K., Yoshizawa, K., Tsuyuguchi, M., Kimura, S., Sumitomo, M., Morita, J., Miyoshi, T., Sakiyama, S., Mukai, K. and Monden, Y. (2004) WHO histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg, 77, pp. 1183-1188.
20. Kondo, K. and Monden, Y. (2005) Thymoma and myasthenia gravis: A clinical study of 1,089 patients from Japan. Ann Thorac Surg, 79, pp. 219-224.
21. Strobel, P., Murumagi, A., Klein, R., Luster, M., Lahti, M., Krohn, K., Schalke, B., Nix, W., Gold, R., Rieckmann, P., Toyka, K., Burek, C., Rosenwald, A., Muller-Hermelink, HK, Pujoll-Borrell, R., Meager, A., Willcox, N., Peterson, P. and Marx, A. (2007) Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type I (ASP-1). J Pathol, 211, pp. 563-571.