Short- and long-term effects of ginkgo biloba extract on sexual dysfunction in women

Archives of Sexual Behavior

Volumn 37, Issue 4, 2008, Pages 530-547

  Meston, Cindy M ^a   Rellini, Alessandra H ^a   Telch, Michael J ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Female sexual dysfunction; Ginkgo biloba; Sex therapy; Vaginal photoplethysmography

Indexed keywords

GINKGO BILOBA EXTRACT; PLACEBO;

ADULT; AGED; AROUSAL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; FEMALE SEXUAL DYSFUNCTION; HUMAN; MAJOR CLINICAL STUDY; ORGASM; PHOTOELECTRIC PLETHYSMOGRAPHY; SENSATION; SEX THERAPY; SEXUAL FUNCTION; SINGLE DRUG DOSE;

ADOLESCENT; ADULT; AGED; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; AROUSAL; COMBINED MODALITY THERAPY; CROSS-OVER STUDIES; DEPRESSIVE DISORDER; FEMALE; HUMANS; LIBIDO; LONG-TERM CARE; PHOTOPLETHYSMOGRAPHY; PHYTOTHERAPY; PLANT EXTRACTS; REGIONAL BLOOD FLOW; SEX EDUCATION; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; SIGNAL PROCESSING, COMPUTER-ASSISTED; VAGINA;

EID: 45849143622     PISSN: 00040002     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10508-008-9316-2     Document Type: Article

References (53)

1. Auguet, M., & Clostre, F. (1983). Effects of an extract of ginkgo biloba and diverse substances on the phasic and tonic components of the contraction of an isolated rabbit aorta. General Pharmacology, 14, 277-280.
2. Auguet, M., DeFeudis, F. V., & Clostre, F. (1982). Effects of ginkgo biloba on arterial smooth muscle responses to vasoactive stimuli. General Pharmacology, 13, 169-171.
3. Azadzoi, K. M., Kim, N., Brown, M. L., Goldstein, I., Cohen, R. A., & Saenz de Tejada, I. (1992). Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. Journal of Urology, 147, 220-225.
4. Basson, R., & Brotto, L. A. (2003). Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: A randomized controlled trial. British Journal of Obstetrics and Gynecology, 100, 1014-1024.
5. Basson, R., McInnes, R., Smith, M. D., Hodgson, G., & Kippiker, N. (2002). Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with Female Sexual Arousal Disorder. Journal of Women's Health & Gender-Based Medicine, 11, 367-377.
6. Boolell, M., Allen, M. J., Ballard, S. A., Gepi-Attee, S., Muirhead, G. J., Naylor, A. M., et al. (1996). Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. International Journal of Impotence Research, 8, 47-52.
7. Bryk, A. S., Raudenbush, S. W., & Congdon, R. T. (1996). Hierarchical linear and nonlinear modeling with the HLM/2L and HLM/3L programs (2nd ed.). Chicago: Scientific Software International Inc.
8. Burnett, A. L. (1997). Nitric oxide in the penis: Physiology and pathology. Journal of Urology, 157, 320-324.
9. Caruso, S., Intelisano, G., Lupo, L., & Agnello, C. (2001). Premenopausal women affected by sexual arousal disorder treated with sildenafil: A double-blind, cross-over, placebo-controlled study. British Journal of Obstetrics and Gynaecology, 108, 623-628.
10. Chivers, M. L., Seto, M. C., Lalumiere, M. L., Laan, E., & Grimbos, T. (2005, July). The agreement of genital and subjective measures of sexual arousal: A meta-analysis. Poster presentation to the annual meeting of the International Academy of Sex Research, Ottawa, Canada.
11. Christen, Y., Courtois, Y., & Droy-Lefaix, M. T. (1995). Effects of ginkgo biloba extract (EGB 761) on aging and age-related disorders. Paris, France: Elsevier.
12. Cohen, A. J., & Bartlik, B. (1998). Ginkgo biloba for antidepressant-induced sexual dysfunction. Journal of Sex and Marital Therapy, 24, 139-143.
13. DeFeudis, F. V. (1991). Ginkgo biloba extract (GBE 761): Pharmacological activities and clinical applications. Paris, France: Elsevier.
14. Dinsmore, W. W., Hodges, M., Hargreaves, C., Osterloh, I. H., Smith, M. D., & Rosen, R. C. (1999). Sildenafil citrate (Viagra) in erectile dysfunction: Near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects. Urology, 53, 800-805. [Erratum in: Urology, 1999, 53, 1072].
15. Dunlop, W. P., Cortina, J. M., Vaslow, J. B., & Burke, M. J. (1996). Meta-analysis of experiments with matched groups or repeated measures designs. Psychological Methods, 1, 170-177.
16. Ellison, J. M., & DeLuca, P. (1998). Fluoxetine-induced genital anesthesia relieved by ginkgo biloba extract. Journal of Clinical Psychiatry, 59, 199-200.
17. FDA Guidance document. (2000). Guidance for industry: Female sexual dysfunction: Clinical development of drug products for treatment. http://www.fda.gov/cder/guidance/3312dft.htm.
18. Foa, E. B., Hembree, E. A., Cahill, S. P., Rauch, S. A. M., Riggs, D. S., Feeny, N. C., et al. (2005). Randomized trial of prolonged exposure for posttraumatic stress disorder with and without cognitive restructuring: Outcome at academic and community clinics. Journal of Consulting and Clinical Psychology, 73, 953-964.
19. Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine, 338, 1397-1404.
20. Janssen, E. (2001). Psychophysiological measurement of sexual arousal. In M. W. Wiederman & B. E. Whitley (Eds.), Handbook for conducting research on human sexuality (pp. 139-171). Mahwah, NJ: Erlbaum.
21. Jung, F., Morowietz, C., Kiesewetter, H., & Wenzel, E. (1990). Effect of ginkgo-biloba on fluidity of blood an peripheral microcirculation in volunteers. Drug Research, 40, 589-593.
22. Kang, B., Lee, S., Kim, M., & Cho, M. (2002). A placebo-controlled, double-blind trial of ginkgo biloba for antidepressant-induced sexual dysfunction. Human Psychopharmacology, 17, 279-284.
23. Kirsch, I. (1997). Specifying nonspecifics: Psychological mechanisms of placebo effects. In A. Harrington (Ed.), The placebo effect: An interdisciplinary exploration (pp. 166-186). Cambridge, MA: Harvard University Press.
24. Kleijnen, J., & Knipschild, P. (1992). Ginkgo biloba. Lancet, 340, 1136-1139.
25. Koltringer, P., Eber, O., Lind, P., Langsteger, W., & Wakonig, P. (1989). Mikrozirkulation und Viskoelastizitat des Vollblutes unter Ginkgo-biloba-extrakt. Eine plazebokontrollierte, randomisierte Doppelblind-Studie. Perfusion, 1, 28-30.
26. Maitra, I., Marcocci, L., Droy-Lefaix, M. T., & Packer, L. (1995). Peroxyl radical scavenging activity of ginkgo biloba extract EGB 761. Biochemical Pharmacology, 49, 1649-1655.
27. Marcocci, L., Maguire, J. J., Droy-Lefaix, M. T., & Paker, L. (1994). The nitric oxide-scavenging properties of ginkgo biloba extract Egb 761. Biochemical and Biophysical Research Communications, 201, 748-755.
28. Marks, L. S., Duda, C., Dorey, F. J., Macairan, M. L., & Santos, P. B. (1999). Treatment of erectile dysfunction with Sildenafil. Urology, 53, 19-24.
29. Meston, C. M. (2003). Validation of the Female Sexual Function Index (FSFI) in women with female orgasmic disorder and in women with hypoactive sexual desire disorder. Journal of Sex & Marital Therapy, 29, 39-46.
30. Meston, C. M., & Gorzalka, B. B. (1992). Psychoactive drugs and human sexual behavior: The role of serotonergic activity. Journal of Psychoactive Drugs, 24, 1-40.
31. Meston, C. M., & Heiman, J. R. (1998). Ephedrine-activated physiological sexual arousal in women. Archives of General Psychiatry, 55, 652-656.
32. Meston, C. M., Rellini, A. H., & McCall, K. M. (2005, October). The sensitivity of continuous laboratory measures of physiological and subjective sexual arousal for diagnosing women's sexual dysfunction. Poster presentation to the annual meeting of the International Society for the Study of Women's Sexual Health, Las Vegas, NV.
33. Meston, C. M., & Trapnell, P. D. (2005). Development and validation of a five factor' sexual satisfaction and distress scale: The Sexual Satisfaction Scale for Women (SSS-W). Journal of Sexual Medicine, 2, 66-81.
34. Montorsi, F., McDermott, T. E., Morgan, R., Olsson, A., Schultz, A., Kirkeby, H. J., et al. (1999). Efficacy and safety of fixed-dose oral sildenafil in the treatment of erectile dysfunction of various etiologies. Urology, 53, 1011-1018.
35. Paick, J. S., & Lee, J. H. (1996). An experimental study of the effect of ginkgo biloba extract on the human and rabbit corpus cavernosum tissue. Journal of Urology, 156, 1876-1880.
36. Park, K., Goldstein, I., Andry, C., Siroky, M., Krane, R. J., & Azadzoi, K. (1997). Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. International Journal of Impotence Research, 9, 27-37.
37. Park, K., Moreland, R. B., Goldstein, I., Atala, A., & Traish, A. (1998). Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle. Biochemical and Biophysical Research Communications, 249, 612-617.
38. Porsolt, R. D., Martin, P., Lenegere, A., Fromage, S., & Drieu, K. (1990). Effects of an extract of ginkgo biloba (GBE 761) on "learned helplessness" and other models of stress in rodents. Pharmacology, Biochemistry and Behavior, 36, 963-971.
39. Prause, N., & Janssen, E. (2005). Blood flow: Vaginal photoplethysmography. In I. Goldstein, C. M. Meston, S. R. Davis, & A. M. Traish (Eds.), Women's sexual function and dysfunction: Study, diagnosis, and treatment (pp. 368-382). London: Taylor & Francis.
40. Rapin, J. R., Lamproglou, I., Drieu, K., & DeFeudis, F. V. (1994). Demonstration of the "anti-stress" activity of an extract of ginkgo biloba (GBE 761) using a discrimination learning task. General Pharmacology, 25, 1009-1016.
41. Rellini, A. H., McCall, K. M., Randall, P. K., & Meston, C. M. (2005). The relationship between self-reported and physiological measures of female sexual arousal. Psychophysiology, 42, 116-124.
42. Rellini, A. H., & Meston, C. M. (2006). The sensitivity of events logs, self-administered questionnaires and photoplethysmography to detect treatment-induced changes in female sexual arousal disorder (FSAD) diagnosis. Journal of Sexual Medicine, 3, 283-291.
43. Rosen, R., D'Agostino, R., Brown, C., Heiman, J., Leiblum, S., Meston, C. M., et al. (2000). The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex and Marital Therapy, 26, 191-208.
44. Rosen, R., Lane, R., & Menza, M. (1999). Effects of SSRIs on sexual function: A critical review. Journal of Clinical Pharmacology, 19, 67-85.
45. Sintchak, G., & Geer, J. H. (1975). A vaginal plethysmograph system. Psychophysiology, 12, 113-115.
46. Smith, P. F., Maclennan, K., & Darlington, C. L. (1996). The neuroprotective properties of the ginkgo biloba leaf: A review of the possible relationship to platelet-activating factor (PAF). Journal of Ethnopharmacology, 50, 131-139.
47. Stimmel, G. L., Dopheide, J. A., & Stahl, S. M. (1997). Mirtazapine: An antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy, 17, 10-21.
48. Straus, J., & von Ammon, C. (1996). Placebo effects: Issues for clinical practice in psychiatry and medicine. Psychosomatics, 37, 315-326.
49. Toesca, A., Stolfi, V. M., & Cocchia, D. (1996). Immunohistochemical study of the corpora cavernosa of the human clitoris. Journal of Anatomy, 188, 513-520.
50. Tyler, V. E. (1993). Ginkgo. In V. E. Tyler (Ed.), The honest herbal (pp. 149-151). New York: Pharmaceutical Products Press.
51. van Beek, T. A., van Scheeren, H. A., Rantio, T., Melger, W. Ch., & Lelyveld, G. P. (1991). Determination of ginkgolides and bilobalide in ginkgo biloba leaves and phytopharmaceuticals. Journal of Chromatography, 543, 375-387.
52. Wiegel, M., Meston, C. M., & Rosen, R. C. (2005). The Female Sexual Function Index (FSFI): Cross-validation and development of clinical cutoff scores. Journal of Sex and Marital Therapy, 31, 1-20.
53. Wiegel, M., Scepkowski, L. A., & Barlow, D. H. (2006). Cognitive and affective processes in female sexual dysfunction. In I. Goldstein, C. M. Meston, S. R. Davis, & A. M. Traish (Eds.), Women's sexual function and dysfunction: Study, diagnosis, and treatment (pp. 85-92). London: Taylor & Francis.