Antibiotic treatment of surgical intensive care patients. Procalcitonin to guide duration of therapy;Antibiotikatherapie bei operativen intensivpatienten. Prokalzitonin zur steuerung der therapiedauer

Anaesthesist

Volumn 57, Issue 6, 2008, Pages 571-577

  Hochreiter, M ^a   Kohler T ^a   Schweiger, A M ^b   Keck, F S ^b   Bein, B ^c   Von Spiegel, T ^a   Schroder S ^a  

^a Academic Teaching Hospital of the Universities of Kiel   (Germany)

^b Medizinische Klinik   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Antibiotics; Duration of therapy; Intensive care medicine; Procalcitonin; Sepsis; Systemic inflammatory response syndrome

Indexed keywords

AMINOPENICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; BETA LACTAMASE INHIBITOR; CARBAPENEM; CEPHALOSPORIN DERIVATIVE; NITROIMIDAZOLE; PROCALCITONIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DEMOGRAPHY; DRUG INDICATION; DRUG POTENCY; FEMALE; HUMAN; INFLAMMATION; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; TREATMENT DURATION; TREATMENT OUTCOME; VIRUS INFECTION;

EID: 45849118675     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00101-008-1379-x     Document Type: Article

References (29)

1. ACCP/SCCM Consensus Conference Committee (1992) Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864-874
2. Bossink A, Groeneveld A, Hack C, Thijs L (1999) The clinical host response to microbial infection in medical patients with fever. Clin Infect Dis 29: 398-407
3. Chastre J, Wolff M, Fagon JY et al. (2003) Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 290: 2588-2598
4. Christ-Crain M, Müller B (2005) Procalcitonin in bacterial infections - hype, hope, more or less? Swiss Med Wkly 135: 451-460
5. Christ-Crain M, Stolz D, Bingisser R et al. (2006) Procalcitonin guidance of antibiotic therapy in community - acquired pneumonia. Am J Respir Crit Care Med 174: 84-93
6. Engel C, Brunkhorst FM, Bone HG et al. (2007) Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med 33: 606-618
7. Engelmann L, Schuster H-P (2006) Diagnostik und Intensivtherapie bei Sepsis und Multiorganversagen. Steinkopff, Darmstadt, S 2-10
8. Harbarth S (2007) Antibiotikatherapie - Einfluss des Antibiotikaverbrauchs auf Resistenzbildung und -selektion. Anasthesiol Intensivmed Notfallmed Schmerzther 2: 130-135
9. Harbarth S, Holeckova K, Froidevaux C et al. (2001) Diagnostic value of procalcitonin, interleukin 6 and interleukin 8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164: 396-402
10. Iregui M, Ward S, Sherman G et al. (2002) Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 122: 262-268
11. Kumar A, Roberts D, Wood KE et al. (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34: 1589-1596
12. Marchetti O, Bille J, Fluckiger U et al.; Fungal Infection Network of Switzerland (2004) Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000. Clin Infect Dis 38: 311-320
13. Meisner M, Tschaikowsky K, Palmaers T, Schmidt J (1999) Comparison of procalcitonin (PCT) and c-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Crit Care 3: 45-50
14. Meisner M (2000) Procalcitonin (PCT) - Ein neuer, innovativer Infektionsparameter. Biochemische und klinische Aspekte 3. Thieme, Stuttgart, S 16-17
15. Meisner M (2000) Procalcitonin (PCT) - Ein neuer, innovativer Infektionsparameter. Biochemische und klinische Aspekte 3. Thieme, Stuttgart, S 34
16. Meyer E, Jonas D, Schwab F et al. (2004) SARI: surveillance of antibiotic use and bacterial resistance in German intensive care units. Correlation between antibiotic use and the emergence of resistance. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 47: 345-351
17. Micek S, Ward S, Fraser VJ, Kollef MH (2004) A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator associated pneumonia. Chest 125: 1791-1799
18. Micek S, Heuring TJ, Hollands JM et al. (2006) Optimizing antibiotic treatment for ventilator-associated pneumonia. Pharmacotherapy 26: 204-213
19. Nobre V, Harbarth S, Graf J-D et al. (2008) Use of procalcitonin to shorten antibiotic treatment duration in septic patients. A randomized trial. Am J Respir Crit Care Med 177: 498-505
20. Oberhoffer M, Vogelsang H, Russwurm S et al. (1999) Outcome prediction by traditional and new markers of inflammation in patients with sepsis. Clin Chem Lab Med 37: 363-368
21. Peres Bota D, Lopes Ferreira F, Mélot C, Vincent JL (2004) Body temperature alterations in the critically ill. Intensive Care Med 30: 811-816
22. Reinhart K, Martin F (2007) S2-Leitlinie: Diagnose und Therapie der Sepsis. Thieme, Stuttgart, S 2-7
23. Singh N, Rogers P, Atwood CW et al. (2000) Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 162: 505-511
24. Trouillet J, Chastre J, Vuagnat A et al. (1998) Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 157: 531-539
25. Vincent JL, Moreno R, Takala J et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22: 707-710
26. Wahl HG, Herzum I, Renze H (2003) Sepsis und Sepsismarker - Update. J Lab Med 27: 431-439
27. Welte T (2004) Antibiotikatherapie bei Sepsis. Dtsch Med Wochenschr 129: 2609-2613
28. Welte T (2006) Die nosokomiale Pneumonie. Intensivmedizin 43: 301-309
29. Yu V, Singh N (2004) Excessive antimicrobial usage cause measurable harm to patients with suspected ventilator - associated pneumonia. Intensive Care Med 30: 735-738