Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice-possible dysfunction of receptor and/or receptor-G protein coupling

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 377, Issue 4-6, 2008, Pages 401-410

  Miike, Tomohiro ^a,b   Kunishiro, Kazuyoshi ^a   Kanda, Mamoru ^a   Azukizawa, Satoru ^a   Kurahashi, Kazuyoshi ^b   Shirahase, Hiroaki ^a  

^a Research Laboratories   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Aorta; db db mouse; Endothelium dependent relaxation; G protein; NaF; Nitric oxide; Nitroprusside

Indexed keywords

2 (2,2 DIMETHYLPROPYL) 7 [2 (5 METHYL 2 PHENYLOXAZOL 4 YL)ETHOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; ACETYLCHOLINE; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTIDIABETIC AGENT; CALCIMYCIN; CALCIUM IONOPHORE; CHOLESTEROL; CHOLINERGIC RECEPTOR; FLUORIDE SODIUM; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; KV 5070; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; OZAGREL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; THROMBOXANE A2; THROMBOXANE SYNTHASE INHIBITOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; AORTA CONSTRICTION; BLOOD VESSEL REACTIVITY; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; SENSITIVITY ANALYSIS; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; HYPERGLYCEMIA; HYPERINSULINISM; HYPERLIPIDEMIAS; MALE; MICE; NITRIC OXIDE; PPAR GAMMA; RECEPTORS, CHOLINERGIC; RECEPTORS, G-PROTEIN-COUPLED; TETRAHYDROISOQUINOLINES; VASODILATOR AGENTS;

EID: 45849117618     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0261-3     Document Type: Conference Paper

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