Mechanisms of Acetylcholine-Induced Vasorelaxation in High K+-Stimulated Rabbit Renal Arteries

Journal of Veterinary Medical Science

Volumn 63, Issue 1, 2001, Pages 41-44

  Kwon, Seong Chun ^a  

^a Yonsei University   (South Korea)

Author keywords

Acetylcholine; Nitric oxide; Rabbit renal artery; Vasorelaxation

Indexed keywords

1 (2 (3 (4 METHOXYPHENYL)PROPOXY) 4 METHOXYPHENYLETHYL) 1H IMIDAZOLE; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; 4 DIPHENYLACETOXY 1,1 DIMETHYLPIPERIDINIUM; 4-DIPHENYLACETOXY-1,1-DIMETHYLPIPERIDINIUM; ACETYLCHOLINE; ATROPINE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; GADOLINIUM; IMIDAZOLE DERIVATIVE; LANTHANUM; MONOVALENT CATION; N(G) NITROARGININE METHYL ESTER; OTENZEPAD; PIPERIDINE DERIVATIVE; PIRENZEPINE; POTASSIUM; TROPICAMIDE;

ANIMAL; ARTICLE; DRUG EFFECT; IN VITRO STUDY; MALE; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; RABBIT; RENAL ARTERY; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; ANIMALS; ATROPINE; CALCIUM; CALCIUM CHANNEL BLOCKERS; CATIONS, MONOVALENT; ENDOTHELIUM, VASCULAR; GADOLINIUM; IMIDAZOLES; LANTHANUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; PARASYMPATHOLYTICS; PIPERIDINES; PIRENZEPINE; POTASSIUM; RABBITS; RENAL ARTERY; TROPICAMIDE; VASOCONSTRICTION; VASODILATION;

EID: 0035229318     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.63.41     Document Type: Article

References (14)

1. Adams, D.J. 1994. Ionic channels in vascular endothelial cells. Trends Pharmacol. Sci. 4: 18-26.
2. Busse, R. and Mulsch, A. 1990. Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett. 265: 133-136.
3. Caldwell, R.A., Clemo, H.F. and Baumgarten, C.M. 1998. Using gadolinium to identify stretch-activated channels: technical considerations. Am. J. Physiol. 275: C619-C621.
4. Chiba, S. and Tsukada, M. 1996. Possible involvement of muscarinic M1 and M3 receptor subtypes mediating vasodilation in isolated, perfused canine lingual arteries. Clin. Exp. Pharmacol. Physiol. 23: 839-843.
5. Kamouchi, M., Mamin, A., Droogmans, G. and Nilius, B. 1999. Nonselective cation channels in endothelial cells derived from human umbilical vein. J. Membr. Biol. 169: 29-38.
6. Komori, K. and Suzuki, H. 1987. Heterogenous distribution of muscarinic receptors in the rabbit saphenous artery. Br. J. Pharmacol. 92: 657-664.
7. 2+ concentrations in the production of endothelial nitric oxide and the control of vascular tone. Br. J. Pharmacol. 101: 489-493.
8. Miller, V.M. and Vanhoutte, P.M. 1992. Endothelium-dependent vascular responsiveness: evolutionary aspects. pp. 3-20. In: Endothelial Regulation of Vascular Tone (Ryan, U.S., Rubanyi, G.M. eds), Marcel Dekker, Inc., New York.
9. Moncada, S., Palmer, R.M.J. and Higgs, E.A. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142.
10. Nilius, B., Viana, F. and Droogmans, G. 1997. Ion channels in vascular endothelium. Ann. Rev. Physiol. 59: 145-170.
11. 2+ signaling in endothelial cells: role of ion channels. Korean J. Physiol. Pharmacol. 2: 133-145.
12. Sato, K., Ozaki, H. and Karaki, H. 1990. Differential effects of carbachol on cytosolic calcium levels in vascular endothelium and smooth muscle. J. Pharmacol. Exp. Ther. 255: 114-119.
13. Viana, F., De Smedt, H., Droogmans, G. and Nilius, B. 1998. Calcium signaling through nucleotide receptor P2Y2 in cultured human vascular endothelium. Cell Calcium 24: 117-127.
14. Wu, C.C., Chen, S.J. and Yen, M.H. 1997. Loss of acetylcholine-induced relaxation by M3-receptor activation in mesenteric arteries of spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 30: 245-252.