Swelling and drug releasing properties of poly(N-isopropylacrylamide) thermo-sensitive copolymer gels

Frontiers of Chemistry in China

Volumn 3, Issue 3, 2008, Pages 314-319

  Pan, Chunyue ^a   Long, Qingde ^a   Yu, Dian ^a   Rao, Yanping ^a   Wu, Nianqian ^a   Li, Xingcui ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Controlled release; Hydrogel; Hydrophilic; Hydrophobic; Swelling

Indexed keywords

EID: 45849104789     PISSN: 16733495     EISSN: 16733614     Source Type: Journal    
DOI: 10.1007/s11458-008-0054-8     Document Type: Article

References (17)

1. Dinarvand R, Emanuele A D. The use of thermal responsive hydrogels for on-off release of molecules. Journal of Controlled Release, 1995, 36: 221-227
2. Dai H J, Chen Q, Qin H L, Guan Y, Shen D Y, Hua Y Q, Tang Y L, Xu J. A temperature-responsive copolymer hydrogel in controlled drug delivery. Macromolecules, 2006, 39(19): 6584-6589
3. Bhattarai N, Ramay H R, Gunn J, Matsen F A, Zhang M. PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release. Journal of Controlled Release, 2005, 103(3): 609-624
4. Feng X, Chen L, Dong J, Li B L. Fast responsive temperature-sensitive hydrogel and its application on bioseparation. Acta Scientiarun Naturaltium Universitatis Nankaiensis, 2005, 38(6): 34-40 (in Chinese)
5. Zhang Y L, Xu L, Yi M, Zhai M L, Wang J R, Ha H F. Radiation synthesis of poly[(dimethylaminoethyl methacrylate)-co-(diallyl dimethyl ammonium chloride)] hydrogels and its application as a carrier for notoginsenoside delivery. European Polymer Journal, 2006, 42(11): 2959-2967
6. Dong J, Chen L, Ding Y M, Han W J. Swelling and mechanical properties of a temperature-sensitive dextran hydrogel and its bioseparation applications. Macromolecular Chemistry and Physics, 2005, 206(19): 1973-1980
7. Zan J, Zhu D Q, Tan F P, Jiang G Q, Lin Y, Ding F X. Preparation of thermosensitive chitosan formulations containing 5-fluorouracil/poly-3- hydroxybutyrate microparticles used as injectable drug delivery system. Chinese Journal of Chemical Engineering, 2006, 14(2): 235-241
8. Lai J H, Pan C Y, Rao Y P. Effect of synthetic temperature on structure and properties of poly(N-isopropylacrylamide) gels. Journal of Central South University of Technology: Natural Science, 2005, 36(6): 1006-1010 (in Chinese)
9. Zhang J T, Huang S W, Liu J, Zhuo R X. Temperature sensitive poly[N-isopropylacrylamide-co-(acryloyl-β-cyclodextrin)] for improved drug release. Macromolecular Bioscience, 2005, 5(3): 192-196
10. Caykara T, Kiper S, Demirel G. Thermo-sensitive poly(N- isopropylacrylamide-co-acrylamide) hydrogels: Synthesis, swelling and interaction with ionic surfactants. European Polymer Journal, 2006, 42(2): 348-355
11. Iwai K, Hanasaki K, Yamamoto M. Fluorescence label studies of thermo-responsive poly(N-isopropylacrylamide) hydrogels. Journal of Luminescence, 2000, 87-89(3-4): 1289-1291
12. Zhang J H, Yang Y J. Stimuli-response of hydrophilic-hydrophobic semi-IPN gel on acetone-water mixture. Journal of Northeast Normal University: Natural Science Edition, 2001, 33(2): 47-51 (in Chinese)
13. Zhang J H. Stimuli response of hydrophilic hydrophobic semi IPN hydrogels on temperature. Acta Physico-Chimica Sinica, 2003, 19(1): 90-93 (in Chinese)
14. Zhang J H, Yang Y J. Stimuli-response of hydrophilic-hydrophobic semi-ipn hydrogels under dc electric field. Acta Polymerica Sinica, 2002, 1: 25-29 (in Chinese)
15. Li L B, Tan Y B. Two Sorts of Problems on drug controlled release from swellable polymer. Journal of Biomedical Engineering, 2003, 20(1): 17-21 (in Chinese)
16. Kim I S, Jeong Y I, Cho C S, et al. Thermo-responsive self-assembled polymeric micelles for drug delivery in vitro. International Journal of Pharmaceutics, 2000, 205: 165-172
17. Zhang X Z, Zhuo R X. Synthesis of temperature-sensitive poly (N-isopropylacrylamide) hydrogel with improved surface property. Journal of Colloid and Interface Science, 2000, 233: 311-313