Toward high-throughput monitoring of metallodrug-protein interaction using capillary electrophoresis in chemically modified capillaries

Analytical Biochemistry

Volumn 379, Issue 2, 2008, Pages 216-218

  Shmykov, Alexei Y ^a   Filippov, Vladimir N ^a   Foteeva, Lidia S ^b   Keppler, Bernhard K ^c   Timerbaev, Andrei R ^b,c  

^a INSTITUTE FOR ANALYTICAL INSTRUMENTATION   (Russian Federation)

^b VERNADSKY INSTITUTE OF GEOCHEMISTRY AND ANALYTICAL CHEMISTRY   (Russian Federation)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CAPILLARY ELECTROPHORESIS; DRUG DELIVERY; DRUG INTERACTIONS; ELECTROLYTES; ELECTROOSMOSIS; PROTEINS; RUTHENIUM COMPOUNDS;

BACK GROUND ELECTROLYTE; CHEMICALLY MODIFIED; COATED CAPILLARIES; ELECTROOSMOTIC FLOW; FUSED-SILICA CAPILLARIES; PROTEIN INTERACTION; RELATIVE STANDARD DEVIATIONS; THEORETICAL PLATES;

FUSED SILICA;

ALBUMIN; INDAZOLIUM TETRACHLOROBIS(INDAZOLE)RUTHENATE; INDAZOLIUM [TETRACHLOROBIS(1H INDAZOLE)RUTHENATE]; RUTHENIUM DERIVATIVE; TRANSFERRIN;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL MODIFICATION; ELECTROOSMOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; SULFONATION;

EID: 45849104220     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.04.043     Document Type: Article

References (14)

1. Timerbaev A.R., Hartinger C.G., Aleksenko S.S., and Keppler B.K. Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology. Chem. Rev. 106 (2006) 2224-2248
2. Timerbaev A.R., Hartinger C.G., and Keppler B.K. Metallodrug research and analysis using capillary electrophoresis. Trends Anal. Chem. 25 (2006) 868-875
3. Timerbaev A.R., and Keppler B.K. Capillary electrophoresis of metal-based drugs. Anal. Biochem. 369 (2007) 1-7
4. Doherty E.A.S., Meagher R.J., Albarghouthi M.N., and Barron A.E. Microchannel wall coatings for protein separations by capillary and chip electrophoresis. Electrophoresis 24 (2003) 34-54
5. Ahmadzadeh H., Dovichi N.J., and Krylov S. Capillary coating for protein separation based on Si-O and Si-C covalent bond formation for capillary electrophoresis with laser-induced fluorescence detection. Methods Mol. Biol. 276 (2004) 15-27
6. Timerbaev A.R., Rudnev A.V., Semenova O., Hartinger C.G., and Keppler B.K. Comparative binding of antitumor indazolium trans-[tetrachlorobis(1H- indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis. Anal. Biochem. 341 (2005) 326-333
7. Horvath J., and Dolnik V. Polymer wall coatings for capillary electrophoresis. Electrophoresis 22 (2001) 644-655
8. Hutterer K., and Dolnik V. Capillary electrophoresis of proteins. Electrophoresis 24 (2003) 3998-4012
9. Li X., Feng Y.Q., Shi Z.G., Da S.L., and Wei F. Preparation of a sulfonated fused-silica capillary and its application in capillary electrophoresis and electrochromatography. J. Chromatogr. A 1033 (2004) 161-166
10. Kodama S., Yamamoto A., Terashima H., Honda Y., Taga A., and Honda S. A sulfonated capillary that gives reproducible migration times for capillary zone electrophoresis and micellar electrokinetic chromatography. Electrophoresis 26 (2005) 4070-4078
11. Bessonova E.A., Kartsova L.A., and Shmukov A.U. Electrophoretic determination of albumin in urine using on-line concentration techniques. J. Chromatogr. A 1150 (2007) 332-338
12. Hartinger C.G., Zorbas-Seifried S., Jakupec M.A., Kynast B., Zorbas H., and Keppler B.K. From bench to bedside: Preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A). J. Inorg. Biochem. 100 (2006) 891-904
13. Lipponer K.G., Vogel E., and Keppler B.K. Synthesis, characterization, and solution chemistry of trans-indazoliumtetrachlorobis(indazole)ruthenate(III), a new anticancer ruthenium complex: IR, UV, NMR, HPLC investigations and antitumor activity. Metal-Based Drugs 3 (1996) 243-260
14. 4L(S-DMSO)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): Aquation, redox properties, protein binding, and antiproliferative activity. J. Med. Chem. 50 (2007) 2185-2193