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1
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0347720695
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Capillary electrophoresis in anti-cancer metallodrug research: Advances and future challenges
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Hartinger C.G., Timerbaev A.R., and Keppler B.K. Capillary electrophoresis in anti-cancer metallodrug research: Advances and future challenges. Electrophoresis 24 (2003) 2023-2037
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Electrophoresis
, vol.24
, pp. 2023-2037
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Hartinger, C.G.1
Timerbaev, A.R.2
Keppler, B.K.3
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2
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32344437845
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Mono-, polynuclear [alkylamine]platinum(II) complexes of [1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II): Synthesis and investigations on cytotoxicity cellular distribution and DNA and protein binding
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Kapp T., Dullin A., and Gust R. Mono-, polynuclear [alkylamine]platinum(II) complexes of [1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II): Synthesis and investigations on cytotoxicity cellular distribution and DNA and protein binding. J. Med. Chem. 49 (2006) 1182-1190
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Kapp, T.1
Dullin, A.2
Gust, R.3
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3
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19544367738
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Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis
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Timerbaev A.R., Rudnev A.V., Semenova O., Hartinger C.G., and Keppler B.K. Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis. Anal. Biochem. 341 (2005) 326-333
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Anal. Biochem.
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Timerbaev, A.R.1
Rudnev, A.V.2
Semenova, O.3
Hartinger, C.G.4
Keppler, B.K.5
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4
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34247616687
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4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): Aquation, redox properties, protein binding, and antiproliferative activity
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4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): Aquation, redox properties, protein binding, and antiproliferative activity. J. Med. Chem. 50 (2007) 2185-2193
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J. Med. Chem.
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Groessl, M.1
Reisner, E.2
Hartinger, C.G.3
Eichinger, R.4
Semenova, O.5
Timerbaev, A.R.6
Jakupec, M.A.7
Arion, V.B.8
Keppler, B.K.9
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5
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33749570781
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Preclinical characterization of anticancer gallium(III) complexes: Solubility, stability, lipophilicity, and binding to serum proteins
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Rudnev A.V., Foteeva L.S., Kowol C., Berger R., Jakupec M.A., Arion V.B., Timerbaev A.R., and Keppler B.K. Preclinical characterization of anticancer gallium(III) complexes: Solubility, stability, lipophilicity, and binding to serum proteins. J. Inorg. Biochem. 100 (2006) 1819-1826
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Rudnev, A.V.1
Foteeva, L.S.2
Kowol, C.3
Berger, R.4
Jakupec, M.A.5
Arion, V.B.6
Timerbaev, A.R.7
Keppler, B.K.8
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6
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15844414509
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Analysis of anticancer platinum(II) complexes by microemulsion electrokinetic chromatography: Separation of diastereomers and estimation of octanol-water partition coefficients
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Rappel C., Galanski M., Yasemi A., Habala L., and Keppler B.K. Analysis of anticancer platinum(II) complexes by microemulsion electrokinetic chromatography: Separation of diastereomers and estimation of octanol-water partition coefficients. Electrophoresis 26 (2005) 878-884
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Electrophoresis
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Rappel, C.1
Galanski, M.2
Yasemi, A.3
Habala, L.4
Keppler, B.K.5
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7
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33847609523
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Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance
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Timerbaev A.R., Vasylenko O.O., Foteeva L.S., Rudnev A.V., Semenova O., and Keppler B.K. Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance. J. Sep. Sci. 30 (2007) 399-406
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J. Sep. Sci.
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Timerbaev, A.R.1
Vasylenko, O.O.2
Foteeva, L.S.3
Rudnev, A.V.4
Semenova, O.5
Keppler, B.K.6
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8
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33947100947
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Development of quantitative structure-activity relationships for interpretation of the migration behavior of neutral platinum(II) complexes in microemulsion electrokinetic chromatography
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Oswałdowski S., and Timerbaev A.R. Development of quantitative structure-activity relationships for interpretation of the migration behavior of neutral platinum(II) complexes in microemulsion electrokinetic chromatography. J. Chromatogr. A 1146 (2007) 258-263
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J. Chromatogr. A
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Oswałdowski, S.1
Timerbaev, A.R.2
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9
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33745763300
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Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology
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Timerbaev A.R., Hartinger C.G., Aleksenko S.S., and Keppler B.K. Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology. Chem. Rev. 106 (2006) 2224-2248
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Chem. Rev.
, vol.106
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Timerbaev, A.R.1
Hartinger, C.G.2
Aleksenko, S.S.3
Keppler, B.K.4
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10
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9244222743
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Synthesis and biological activity of water-soluble maleimide derivatives of the anticancer drug carboplatin designed as albumin-binding prodrugs
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Warnecke A., Fichtner I., Garmann D., Jaehde U., and Kratz F. Synthesis and biological activity of water-soluble maleimide derivatives of the anticancer drug carboplatin designed as albumin-binding prodrugs. Bioconj. Chem. 15 (2004) 1349-1359
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Warnecke, A.1
Fichtner, I.2
Garmann, D.3
Jaehde, U.4
Kratz, F.5
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11
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4344561392
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Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: Characterization of interactions between Pt(II) complexes and human serum albumin
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Timerbaev A.R., Aleksenko S.S., Polec-Pawlak K., Ruzik R., Semenova O., Hartinger C.G., Oszwaldowski S., Galanski M., Jarosz M., and Keppler B.K. Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: Characterization of interactions between Pt(II) complexes and human serum albumin. Electrophoresis 25 (2004) 1988-1995
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Electrophoresis
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Timerbaev, A.R.1
Aleksenko, S.S.2
Polec-Pawlak, K.3
Ruzik, R.4
Semenova, O.5
Hartinger, C.G.6
Oszwaldowski, S.7
Galanski, M.8
Jarosz, M.9
Keppler, B.K.10
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12
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33645466179
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Platinum group metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: A further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins
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Polec-Pawlak K., Abramski J.K., Semenova O., Hartinger C.G., Timerbaev A.R., Keppler B.K., and Jarosz M. Platinum group metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: A further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins. Electrophoresis 27 (2006) 1128-1135
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Electrophoresis
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Polec-Pawlak, K.1
Abramski, J.K.2
Semenova, O.3
Hartinger, C.G.4
Timerbaev, A.R.5
Keppler, B.K.6
Jarosz, M.7
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13
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29444434345
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Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins: Significance for the patient
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Hartinger C.G., Hann S., Koellensperger G., Sulyok M., Groessl M., Timerbaev A.R., Rudnev A.V., Stingeder G., and Keppler B.K. Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins: Significance for the patient. Intl. J. Clin. Pharmacol. Ther. 43 (2005) 583-585
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Hartinger, C.G.1
Hann, S.2
Koellensperger, G.3
Sulyok, M.4
Groessl, M.5
Timerbaev, A.R.6
Rudnev, A.V.7
Stingeder, G.8
Keppler, B.K.9
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14
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34548187526
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A.R. Timerbaev, L.S. Foteeva, A.V. Rudnev, J.K. Abramski, K. Połeć-Pawlak, C.G. Hartinger, M. Jarosz, B.K. Keppler, Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using capillary electrophoresis, Electrophoresis (in press).
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15
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14944347152
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Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method
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Rudnev A.V., Aleksenko S.S., Semenova O., Hartinger C.G., Timerbaev A.R., and Keppler B.K. Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method. J. Sep. Sci. 28 (2005) 121-127
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J. Sep. Sci.
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Rudnev, A.V.1
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Semenova, O.3
Hartinger, C.G.4
Timerbaev, A.R.5
Keppler, B.K.6
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16
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33745683745
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The effects of drug complexation on the stability and conformation of human serum albumin: Protein unfolding
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Ahmed-Ouameur A., Diamantoglou S., Sedaghat-Herati M.R., Nafisi S., Carpentier R., and Tajmir-Riahi H.A. The effects of drug complexation on the stability and conformation of human serum albumin: Protein unfolding. Cell Biochem. Biophys. 45 (2006) 203-213
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Cell Biochem. Biophys.
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Ahmed-Ouameur, A.1
Diamantoglou, S.2
Sedaghat-Herati, M.R.3
Nafisi, S.4
Carpentier, R.5
Tajmir-Riahi, H.A.6
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17
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34548192279
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S.S. Aleksenko, C.G. Hartinger, O. Semenova, K. Meelich, A.R. Timerbaev, B.K. Keppler, Characterization of interactions between human serum albumin and tumor-inhibiting aminoalcohol platinum(II) complexes using capillary electrophoresis, J. Chromatogr. A (in press).
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18
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0346504188
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Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: Comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry
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Hartinger C.G., Schluga P., Galanski M., Baumgartner C., Timerbaev A.R., and Keppler B.K. Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: Comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry. Electrophoresis 24 (2003) 2038-2044
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Electrophoresis
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Hartinger, C.G.1
Schluga, P.2
Galanski, M.3
Baumgartner, C.4
Timerbaev, A.R.5
Keppler, B.K.6
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19
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3242766909
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2 N,O)platinum(II): A representative of novel pH sensitive anticancer platinum complexes
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2 N,O)platinum(II): A representative of novel pH sensitive anticancer platinum complexes. Inorg. Chim. Acta 357 (2004) 3237-3244
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Inorg. Chim. Acta
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Baumgartner, C.2
Meelich, K.3
Arion, V.B.4
Fremuth, M.5
Jakupec, M.A.6
Schluga, P.7
Hartinger, C.G.8
von Keyserlingk, N.G.9
Keppler, B.K.10
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20
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34548158774
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Activation of anticancer platinum complexes by tumoral acidity
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Meelich K., Galanski M., Arion V.B., Jakupec M.A., Schluga P., Hartinger C.G., von Keyserlingk N.G., and Keppler B.K. Activation of anticancer platinum complexes by tumoral acidity. Metal Ions Biol. Med. 9 (2006) 52-58
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Metal Ions Biol. Med.
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Meelich, K.1
Galanski, M.2
Arion, V.B.3
Jakupec, M.A.4
Schluga, P.5
Hartinger, C.G.6
von Keyserlingk, N.G.7
Keppler, B.K.8
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21
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33845884312
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Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands
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Zorbas-Seifried S., Jakupec M.A., Kukushkin N.V., Groessl M., Hartinger C.G., Semenova O., Zorbas H., Kukushkin V.Y., and Keppler B.K. Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands. Mol. Pharmacol. 71 (2007) 357-365
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Mol. Pharmacol.
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Zorbas-Seifried, S.1
Jakupec, M.A.2
Kukushkin, N.V.3
Groessl, M.4
Hartinger, C.G.5
Semenova, O.6
Zorbas, H.7
Kukushkin, V.Y.8
Keppler, B.K.9
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22
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34548151874
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I. Berger, A.A. Nazarov, C.G. Hartinger, M. Groessl, B.K. Keppler, Rational development of oxaliplatin analogues: Synthesis and preliminary structure-activity relationships, ChemBioChem., in press.
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23
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27144515499
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Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: Biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy, and mass spectrometry
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Schluga P., Hartinger C.G., Galanski M., Meelich K., Timerbaev A.R., and Keppler B.K. Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: Biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy, and mass spectrometry. Analyst 130 (2005) 1383-1389
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Analyst
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Schluga, P.1
Hartinger, C.G.2
Galanski, M.3
Meelich, K.4
Timerbaev, A.R.5
Keppler, B.K.6
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24
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8844258069
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Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: Indications of guanosine 5′-monophosphate O6-N7 chelation
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Warnke U., Rappel C., Meier H., Kloft C., Galanski M., Hartinger C.G., Keppler B.K., and Jaehde U. Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: Indications of guanosine 5′-monophosphate O6-N7 chelation. Chem. Bio. Chem. 5 (2004) 1543-1549
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Chem. Bio. Chem.
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Warnke, U.1
Rappel, C.2
Meier, H.3
Kloft, C.4
Galanski, M.5
Hartinger, C.G.6
Keppler, B.K.7
Jaehde, U.8
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25
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33645277617
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Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP
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Schluga P., Hartinger C.G., Egger A., Reisner E., Galanski M., Jakupec M.A., and Keppler B.K. Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP. Dalton Trans. (2006) 1796-1802
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Dalton Trans.
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Schluga, P.1
Hartinger, C.G.2
Egger, A.3
Reisner, E.4
Galanski, M.5
Jakupec, M.A.6
Keppler, B.K.7
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27
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33846313227
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Binding of oxovanadium ions to the major and minor grooves of DNA duplex: Stability and structural models
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Ahmed-Ouameur A., Arakawa H., and Tajmir-Riahi H.A. Binding of oxovanadium ions to the major and minor grooves of DNA duplex: Stability and structural models. Biochem. Cell Biol. 84 (2006) 677-683
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Biochem. Cell Biol.
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Ahmed-Ouameur, A.1
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Tajmir-Riahi, H.A.3
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28
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31344440769
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Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques
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Huang Z., Timerbaev A.R., Keppler B.K., and Hirokawa T. Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques. J. Chromatogr. A 106 (2006) 75-79
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J. Chromatogr. A
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Huang, Z.1
Timerbaev, A.R.2
Keppler, B.K.3
Hirokawa, T.4
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