Reduced T-cadherin expression and promoter methylation are associated with the development and progression of hepatocellular carcinoma

International Journal of Oncology

Volumn 32, Issue 5, 2008, Pages 1057-1063

  Yan, Qun ^a   Zhang, Zhi Fa ^a   Chen, Xiao Ping ^a   Gutmann, David H ^b   Xiong, Min ^a   Xiao, Zhen Yu ^a   Huang, Zhi Yong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Expression; Hepatocellular carcinoma; Methylation; T cadherin

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CADHERIN; T CADHERIN; UNCLASSIFIED DRUG; AZACITIDINE; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; H CADHERIN; H-CADHERIN; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HEPG2; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GROWTH REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; CANCER INVASION; CELL DIFFERENTIATION; CHEMISTRY; DISEASE COURSE; DNA METHYLATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; TUMOR CELL LINE;

ADULT; AGED; AZACITIDINE; CADHERINS; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DNA METHYLATION; DNA MODIFICATION METHYLASES; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROMOTER REGIONS (GENETICS); TUMOR SUPPRESSOR PROTEINS;

EID: 45849088842     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.32.5.1057     Document Type: Article

References (46)

1. Chen XP and Huang ZY: Surgical treatment of hepatocellular carcinoma in China: surgical techniques, indications and outcomes. Langenbecks Arch Surg 390: 259-265, 2005.
2. Chen XP, Wu ZD, Huang ZY and Qiu FZ: Use of hepatectomy and splenectomy to treat hepatocellular carcinoma with cirrhotic hypersplenism. Br J Surg 92: 334-339, 2005.
3. Chen XP, Qiu FZ, Wu ZD, Zhang ZW, Huang ZY and Chen YF: Long-term outcome of resection of large hepatocellular carcinoma. Br J Surg 93: 600-606, 2006.
4. Chen CJ, Yu MW and Liaw YF: Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol 12: S294-S308, 1997.
5. Yeh SH, Chen PJ, Lai MY and Chen DS: Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: association with elevated α-fetoprotein production. Gastroenterology 110: 184-192, 1996.
6. Piao Z, Kim H, Jeon BK, Lee WJ and Park C: Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma. Cancer 80: 865-872, 1997.
7. Dewantoro O, Gani RA and Akbar N: Hepatocarsinogenesis in viral hepatitis B infection: the Role of HBx and p53. Acta Med Indones 38: 154-159, 2006.
8. Feitelson MA, Pan J and Lian Z: Early molecular and genetic determinants of primary liver malignancy. Surg Clin North Am 84: 339-354, 2004.
9. Suriawinata A and Xu R: An update on the molecular genetics of hepatocellular carcinoma. Semin Liver Dis 24: 77-88, 2004.
10. Ikeguchi M, Iwamoto A, Taniguchi K, Katano K and Hirooka Y: The gene expression level of transforming growth factor-beta (TGF-beta) as a biological prognostic marker of hepatocellular carcinoma. J Exp Clin Cancer Res 24: 415-421, 2005.
11. Calvisi DF, Ladu S, Gorden A, et al: Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 130: 1117-1128, 2006.
12. Elangbam CS, Qualls CW Jr and Dahlgren RR: Cell adhesion molecules - update. Vet Pathol 34: 61-73, 1997.
13. Albelda SM: Role of integrin and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 68: 4-17, 1993.
14. Berx G and F Van Roy F: The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res 3: 289-293, 2001.
15. Bremnes RM, Veve R, Gabrielson E, et al: High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol 20: 2417-2428, 2002.
16. Handschuh G, Candidus S, Luber B, et al: Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility. Oncogene 18: 4301-4312, 1999.
17. Levenberg S, Yarden A, Kam Z and Geiger B: p27 is involved 7in N-cadherin-mediated contact inhibition of cell growth and S-phase entry. Oncogene 18: 869-876, 1999.
18. Nieman MT, Prudoff RS, Johnson KR and Wheelock MJ: N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 147: 631-644, 1999.
19. Vleminckx K, Vakaet L, Mareel M, Fiers W and van Roy F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107-119, 1991.
20. Yang B, Guo M, Herman JG and Clark DP: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163: 1101-1107, 2003.
21. Kwon GY, Yoo BC, Koh KC, Cho JW, Park WS and Park CK: Promoter methylation of E-cadherin in hepatocellular carcinomas and dysplastic nodules. J Korean Med Sci 20: 242-247, 2005.
22. Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ and Kang GH: Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 163: 1371-1378, 2003.
23. Angst BD, Marcozzi C and Magee AI: The cadherin super-family: diversity in form and function. J Cell Sci 114: 629-641, 2001.
24. Ranscht Band Dours-Zimmermann MT: T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron 7: 391-402, 1991.
25. Vestal DJ and Ranscht B: Glycosyl phosphatidylinositol-anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion. J Cell Biol 119: 451-461, 1992.
26. Doyle DD, Goings GE, Upshaw-Earley J, Page E, Ranscht B and Palfrey HC: T-cadherin is a major glycophosphoinositol-anchored protein associated with non-caveolar detergent-insoluble domains of the cardiac sarcolemma. J Biol Chem 273: 6937-6943, 1998.
27. Kinch MS, Petch L, Zhong C and Burridge K: E-cadherin engagement stimulates tyrosine phosphorylation. Cell Adhes Commun 4: 425-437, 1997.
28. Philippova MP, Bochkov VN, Stambolsky DV, Tkachuk VA and Resink TJ: T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells. FEBS Lett 429: 207-210, 1998.
29. Huang ZY, Wu Y, Hedrick N and Gutmann DH: T-Cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21C1P1/WAF1 expression. Mol Cell Biol 23: 566-578, 2003.
30. Lee SW: H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nat Med 2: 776-782, 1996.
31. Toyooka KO, Toyooka S, Virmani AK, et al: Loss of expression and aberrant methylation of the CDHI3 (H-cadherin) gene in breast and lung carcinomas. Cancer Res 61: 4556-4560, 2001.
32. Zhong Y, Delgado Y, Gomez J, Lee SW and Perez-Soler R: Loss of H-cadherin protein expression in human non-small cell lung cancer is associated with tumorigenicity. Clin Cancer Res 7: 1683-1687, 2001.
33. Sakai M, Hibi K, Koshikawa K, Inoue S, Takeda S, Kaneko T and Nakao A: Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer. Cancer Sci 95: 588-591, 2004.
34. Kawakami M, Staub J, Cliby W, Hartmann L, Smith DI and Shridhar V: Involvement of H-cadherin (CDH13) on 16q in the region of frequent deletion in ovarian cancer. Int J Oncol 15: 715-720, 1999.
35. Takeuchi T, Liang SB, Matsuyoshi N, Zhou S, Miyachi Y, Sonobe H and Ohtsuki Y: Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma. Lab Invest 82: 1023-1029, 2002.
36. Riou P, Saffroy R, Comoy J, et al: Investigation in liver tissues and cell lines of the transcription of 13 genes mapping to the 16q24 region that are frequently deleted in hepatocellular carcinoma. Clin Cancer Res 8: 3178-3186, 2002.
37. Wang RY, Gehrke CW and Ehrlich M: Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues. Nucleic Acids Res 8: 4777-4790, 1980.
38. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996.
39. Sato M, Mori Y, Sakurada A, Fujimura S and Horii A: The H-cadherin (CDH13) gene is inactivated in human lung cancer. Hum Genet 103: 96-101, 1998.
40. Gutmann DH, Huang ZY, Hedrick NM, Ding H, Guha A and Watson MA: Mouse glioma gene expression profiling identifies novel human glioma-associated genes. Ann Neurol 51: 393-405, 2002.
41. Miki Y, Katagiri T and Nakamura Y: Infrequent mutation of the H-cadherin gene on chromosome 16q24 in human breast cancers. Jpn J Cancer Res 88: 701-704, 1997.
42. Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A and Dejean A: Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 18: 59-65, 1997.
43. Fiegl H, Millinger S, Goebel G, et al: Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res 66: 29-33, 2006.
44. Ulivi P, Zoli W, Calistri D, et al: p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients. J Cell Physiol 206: 611-615, 2006.
45. Kim JS, Han J, Shim YM, Park J and Kim DH: Aberrant methylation of H-cadherin (CDH13) promoter is associated with tumor progression in primary non-small cell lung carcinoma. Cancer 104: 1825-1833, 2005.
46. Hibi K, Kodera Y, Ito K, Akiyama S and Nakao A: Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis. Dis Colon Rectum 48: 1282-1286, 2005.