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Volumn 326, Issue 1, 2008, Pages 259-269

Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; DAUNORUBICIN; DEFERIPRONE; MALONALDEHYDE; TROPONIN T;

EID: 45749156776     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.137604     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia
    • Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, and Pennell DJ (2002) Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia. Lancet 360:516-520.
    • (2002) Lancet , vol.360 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3    Holden, S.4    Walker, J.M.5    Pennell, D.J.6
  • 3
    • 34548301545 scopus 로고    scopus 로고
    • Protection by flavonoids against anthracycline cardiotoxicity: From chemistry to clinical trials
    • Bast A, Haenen GR, Bruynzeel AM, and Van der Vijgh WJ (2007) Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials. Cardiovasc Toxicol 7:154-159.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 154-159
    • Bast, A.1    Haenen, G.R.2    Bruynzeel, A.M.3    Van der Vijgh, W.J.4
  • 5
    • 0036310616 scopus 로고    scopus 로고
    • Pharmacokineticpharmacodynamic relationships of the anthracycline anticancer drugs
    • Danesi R, Fogli S, Gennari A, Conte P, and Del Tacca M (2002) Pharmacokineticpharmacodynamic relationships of the anthracycline anticancer drugs. Clin Pharmacokinet 41:431-444.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 431-444
    • Danesi, R.1    Fogli, S.2    Gennari, A.3    Conte, P.4    Del Tacca, M.5
  • 8
    • 33750001927 scopus 로고    scopus 로고
    • Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
    • Glickstein H, El RB, Link G, Breuer W, Konijn AM, Hershko C, Nick H, and Cabantchik ZI (2006) Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood 108:3195-3203.
    • (2006) Blood , vol.108 , pp. 3195-3203
    • Glickstein, H.1    El, R.B.2    Link, G.3    Breuer, W.4    Konijn, A.M.5    Hershko, C.6    Nick, H.7    Cabantchik, Z.I.8
  • 9
    • 0035181433 scopus 로고    scopus 로고
    • Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: Effect on the R2 subunit of ribonucleotide reductase
    • Green DA, Antholine WE, Wong SJ, Richardson DR, and Chitambar CR (2001) Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase. Clin Cancer Res 7:3574-3579.
    • (2001) Clin Cancer Res , vol.7 , pp. 3574-3579
    • Green, D.A.1    Antholine, W.E.2    Wong, S.J.3    Richardson, D.R.4    Chitambar, C.R.5
  • 10
    • 0031906718 scopus 로고    scopus 로고
    • Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
    • Hasinoff BB, Hellmann K, Herman EH, and Ferrans VJ (1998) Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines. Curr Med Chem 5:1-28.
    • (1998) Curr Med Chem , vol.5 , pp. 1-28
    • Hasinoff, B.B.1    Hellmann, K.2    Herman, E.H.3    Ferrans, V.J.4
  • 11
    • 0345306160 scopus 로고    scopus 로고
    • The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin
    • Hasinoff BB, Patel D, and Wu X (2003) The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin. Free Radic Biol Med 35:1469-1479.
    • (2003) Free Radic Biol Med , vol.35 , pp. 1469-1479
    • Hasinoff, B.B.1    Patel, D.2    Wu, X.3
  • 12
    • 0028080144 scopus 로고
    • Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats
    • Herman EH, Zhang J, and Ferrans VJ (1994) Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats. Cancer Chemother Pharmacol 35:93-100.
    • (1994) Cancer Chemother Pharmacol , vol.35 , pp. 93-100
    • Herman, E.H.1    Zhang, J.2    Ferrans, V.J.3
  • 13
    • 0030744361 scopus 로고    scopus 로고
    • Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron (III) displacement reactions of ICRF-187 and other bisdiketopiperazines
    • Herman EH, Zhang J, Hasinoff BB, Chadwick DP, Clark JR Jr., and Ferrans VJ (1997) Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron (III) displacement reactions of ICRF-187 and other bisdiketopiperazines. Cancer Chemother Pharmacol 40:400-408.
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 400-408
    • Herman, E.H.1    Zhang, J.2    Hasinoff, B.B.3    Chadwick, D.P.4    Clark Jr., J.R.5    Ferrans, V.J.6
  • 14
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory Animal Resources , 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC
    • Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 16
    • 0025283897 scopus 로고
    • Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity
    • Keizer HG, Pinedo HM, Schuurhuis GJ, and Joenje H (1990) Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther 47:219-231.
    • (1990) Pharmacol Ther , vol.47 , pp. 219-231
    • Keizer, H.G.1    Pinedo, H.M.2    Schuurhuis, G.J.3    Joenje, H.4
  • 17
    • 3242753676 scopus 로고    scopus 로고
    • The design and development of deferiprone (L1) and other iron chelators for clinical use: Targeting methods and application prospects
    • Kontoghiorghes GJ, Pattichis K, Neocleous K, and Kolnagou A (2004) The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects. Curr Med Chem 11:2161-2183.
    • (2004) Curr Med Chem , vol.11 , pp. 2161-2183
    • Kontoghiorghes, G.J.1    Pattichis, K.2    Neocleous, K.3    Kolnagou, A.4
  • 18
    • 0037379680 scopus 로고    scopus 로고
    • Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: Inhibition of the ferritin iron mobilization pathway
    • Kwok JC and Richardson DR (2003) Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: inhibition of the ferritin iron mobilization pathway. Mol Pharmacol 63:849-861.
    • (2003) Mol Pharmacol , vol.63 , pp. 849-861
    • Kwok, J.C.1    Richardson, D.R.2
  • 19
    • 34447573788 scopus 로고    scopus 로고
    • Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats
    • Lebrecht D, Geist A, Ketelsen UP, Haberstroh J, Setzer B, and Walker UA (2007) Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br J Pharmacol 151:771-778.
    • (2007) Br J Pharmacol , vol.151 , pp. 771-778
    • Lebrecht, D.1    Geist, A.2    Ketelsen, U.P.3    Haberstroh, J.4    Setzer, B.5    Walker, U.A.6
  • 21
    • 34548675357 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: A possible relationship with polyamine metabolism
    • Lescoat G, Chantrel-Groussard K, Pasdeloup N, Nick H, Brissot P, and Gaboriau F (2007) Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism. Cell Prolif 40:755-767.
    • (2007) Cell Prolif , vol.40 , pp. 755-767
    • Lescoat, G.1    Chantrel-Groussard, K.2    Pasdeloup, N.3    Nick, H.4    Brissot, P.5    Gaboriau, F.6
  • 22
    • 0030091567 scopus 로고    scopus 로고
    • Role of iron in the potentiation of anthracycline cardiotoxicity: Identification of heart cell mitochondria as a major site of iron-anthracycline interaction
    • Link G, Tirosh R, Pinson A, and Hershko C (1996) Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction. J Lab Clin Med 127:272-278.
    • (1996) J Lab Clin Med , vol.127 , pp. 272-278
    • Link, G.1    Tirosh, R.2    Pinson, A.3    Hershko, C.4
  • 23
    • 34548301536 scopus 로고    scopus 로고
    • An introduction to the metabolic determinants of anthracycline cardiotoxicity
    • Menna P, Recalcati S, Cairo G, and Minotti G (2007) An introduction to the metabolic determinants of anthracycline cardiotoxicity. Cardiovasc Toxicol 7:80-85.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 80-85
    • Menna, P.1    Recalcati, S.2    Cairo, G.3    Minotti, G.4
  • 24
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • Minotti G, Menna P, Salvatorelli E, Cairo G, and Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185-229.
    • (2004) Pharmacol Rev , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 25
  • 27
    • 0034625677 scopus 로고    scopus 로고
    • Measurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2,4-dinitrophenylhydrazine derivative
    • Pilz J, Meineke I, and Gleiter CH (2000) Measurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2,4-dinitrophenylhydrazine derivative. J Chromatogr B Biomed Sci Appl 742:315-325.
    • (2000) J Chromatogr B Biomed Sci Appl , vol.742 , pp. 315-325
    • Pilz, J.1    Meineke, I.2    Gleiter, C.H.3
  • 28
    • 0025201168 scopus 로고
    • Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice
    • Porter JB, Morgan J, Hoyes KP, Burke LC, Huehns ER, and Hider RC (1990) Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice. Blood 76:2389-2396.
    • (1990) Blood , vol.76 , pp. 2389-2396
    • Porter, J.B.1    Morgan, J.2    Hoyes, K.P.3    Burke, L.C.4    Huehns, E.R.5    Hider, R.C.6
  • 29
    • 27744528421 scopus 로고    scopus 로고
    • Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer
    • Richardson DR (2005) Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer. Curr Med Chem 12:2711-2729.
    • (2005) Curr Med Chem , vol.12 , pp. 2711-2729
    • Richardson, D.R.1
  • 30
    • 0034957066 scopus 로고    scopus 로고
    • The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats
    • Saad SY, Najjar TA, and Al-Rikabi AC (2001) The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. Pharmacol Res 43:211-218.
    • (2001) Pharmacol Res , vol.43 , pp. 211-218
    • Saad, S.Y.1    Najjar, T.A.2    Al-Rikabi, A.C.3
  • 34
    • 34248384887 scopus 로고    scopus 로고
    • Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)
    • Sterba M, Popelova O, Simunek T, Mazurova Y, Potacova A, Adamcova M, Guncova I, Kaiserova H, Palicka V, Ponka P, et al. (2007a) Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH). Toxicology 235:150-166.
    • (2007) Toxicology , vol.235 , pp. 150-166
    • Sterba, M.1    Popelova, O.2    Simunek, T.3    Mazurova, Y.4    Potacova, A.5    Adamcova, M.6    Guncova, I.7    Kaiserova, H.8    Palicka, V.9    Ponka, P.10
  • 35
    • 33751187356 scopus 로고    scopus 로고
    • Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity
    • Sterba M, Popelova O, Simunek T, Mazurova Y, Potacova A, Adamcova M, Kaiserova H, Ponka P, and Gersl V (2006) Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity. J Pharmacol Exp Ther 319:1336-1347.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1336-1347
    • Sterba, M.1    Popelova, O.2    Simunek, T.3    Mazurova, Y.4    Potacova, A.5    Adamcova, M.6    Kaiserova, H.7    Ponka, P.8    Gersl, V.9
  • 36
    • 36849022195 scopus 로고    scopus 로고
    • Early detection of anthracycline cardiotoxicity in a rabbit model: Left ventricle filling pattern versus troponin T determination
    • Sterba M, Simunek T, Popelova O, Potacova A, Adamcova M, Mazurova Y, Holeckova M, and Gersl V (2007b) Early detection of anthracycline cardiotoxicity in a rabbit model: left ventricle filling pattern versus troponin T determination. Physiol Res 56:535-545.
    • (2007) Physiol Res , vol.56 , pp. 535-545
    • Sterba, M.1    Simunek, T.2    Popelova, O.3    Potacova, A.4    Adamcova, M.5    Mazurova, Y.6    Holeckova, M.7    Gersl, V.8
  • 37
    • 42749107115 scopus 로고    scopus 로고
    • Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy
    • CD005008
    • van Dalen EC, van der Pal HJ, Caron HN, and Kremer LC (2006) Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy. Cochrane Database Syst Rev:CD005008.
    • (2006) Cochrane Database Syst Rev
    • van Dalen, E.C.1    van der Pal, H.J.2    Caron, H.N.3    Kremer, L.C.4
  • 38
    • 34548299678 scopus 로고    scopus 로고
    • Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis
    • Wallace KB (2007) Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis. Cardiovasc Toxicol 7:101-107.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 101-107
    • Wallace, K.B.1
  • 40
    • 33644806519 scopus 로고    scopus 로고
    • Protecting against anthracycline-induced myocardial damage: A review of the most promising strategies
    • Wouters KA, Kremer LC, Miller TL, Herman EH, and Lipshultz SE (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131:561-578.
    • (2005) Br J Haematol , vol.131 , pp. 561-578
    • Wouters, K.A.1    Kremer, L.C.2    Miller, T.L.3    Herman, E.H.4    Lipshultz, S.E.5
  • 41
    • 33748968521 scopus 로고    scopus 로고
    • Deferiprone protects the isolated atria from cardiotoxicity induced by doxorubicin
    • Xu LJ, Jin L, Pan H, Zhang AZ, Wei G, Li PP, and Lu WY (2006) Deferiprone protects the isolated atria from cardiotoxicity induced by doxorubicin. Acta Pharmacol Sin 27:1333-1339.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 1333-1339
    • Xu, L.J.1    Jin, L.2    Pan, H.3    Zhang, A.Z.4    Wei, G.5    Li, P.P.6    Lu, W.Y.7
  • 42
    • 23044447053 scopus 로고    scopus 로고
    • Molecular pharmacology of the interaction of anthracyclines with iron
    • Xu X, Persson HL, and Richardson DR (2005) Molecular pharmacology of the interaction of anthracyclines with iron. Mol Pharmacol 68:261-271.
    • (2005) Mol Pharmacol , vol.68 , pp. 261-271
    • Xu, X.1    Persson, H.L.2    Richardson, D.R.3
  • 43
    • 40849085410 scopus 로고    scopus 로고
    • Iron chelation by clinically relevant anthracyclines: Alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking
    • Xu X, Sutak R, and Richardson DR (2008) Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking. Mol Pharmacol 73:833-844.
    • (2008) Mol Pharmacol , vol.73 , pp. 833-844
    • Xu, X.1    Sutak, R.2    Richardson, D.R.3
  • 45
    • 0028882170 scopus 로고
    • Influence of lipophilicity on the bioavailability and disposition of orally active 3-hydroxypyridin-4-one metal chelators
    • Yokel RA, Fredenburg AM, Meurer KA, and Skinner TL (1995) Influence of lipophilicity on the bioavailability and disposition of orally active 3-hydroxypyridin-4-one metal chelators. Drug Metab Dispos 23:1178-1180.
    • (1995) Drug Metab Dispos , vol.23 , pp. 1178-1180
    • Yokel, R.A.1    Fredenburg, A.M.2    Meurer, K.A.3    Skinner, T.L.4


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