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Volumn 30, Issue 5, 2008, Pages 557-565

Simvastatin alleviates diabetes-induced VEGF-mediated nephropathy via the modulation of Ras signaling pathway

Author keywords

Diabetes; Ras; Simvastatin; Vascular endothelial growth factor (VEGF)

Indexed keywords

GLUCOSE; MANUMYCIN; MANUMYCIN A; MESSENGER RNA; MEVINOLIN; RAS PROTEIN; SIMVASTATIN; VASCULOTROPIN;

EID: 45749129025     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.1080/08860220802064457     Document Type: Article
Times cited : (17)

References (29)
  • 1
    • 34548397224 scopus 로고    scopus 로고
    • Molecular mechanisms of diabetic nephropathy and its therapeutic intervention
    • Yamagishi S, Fukami K, Ueda S, Okuda S. Molecular mechanisms of diabetic nephropathy and its therapeutic intervention. Curr Drug Targets. 2007;8:952-959.
    • (2007) Curr Drug Targets , vol.8 , pp. 952-959
    • Yamagishi, S.1    Fukami, K.2    Ueda, S.3    Okuda, S.4
  • 3
    • 0033789935 scopus 로고    scopus 로고
    • Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease
    • Flyvbjerg A. Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease. Diabetologia. 2000;43:1205-1223.
    • (2000) Diabetologia , vol.43 , pp. 1205-1223
    • Flyvbjerg, A.1
  • 4
    • 0031000258 scopus 로고    scopus 로고
    • Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor
    • Tilton RG, Kawamura T, Chang KC, et al. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest. 1997;99:2192-2202.
    • (1997) J Clin Invest , vol.99 , pp. 2192-2202
    • Tilton, R.G.1    Kawamura, T.2    Chang, K.C.3
  • 5
    • 0032712434 scopus 로고    scopus 로고
    • Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
    • Cooper ME, Vranes D, Youssef S, et al. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes. 1999;48:2229-2239.
    • (1999) Diabetes , vol.48 , pp. 2229-2239
    • Cooper, M.E.1    Vranes, D.2    Youssef, S.3
  • 6
    • 0035034655 scopus 로고    scopus 로고
    • Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes
    • De Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH. Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol. 2001;12:993-1000.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 993-1000
    • De Vriese, A.S.1    Tilton, R.G.2    Elger, M.3    Stephan, C.C.4    Kriz, W.5    Lameire, N.H.6
  • 7
    • 0036789207 scopus 로고    scopus 로고
    • Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody
    • Flyvbjerg A, Dagnaes-Hansen F, de Vriese AS, Schrijvers BF, Tilton RG, Rasch R. Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes. 2002;51:3090-3094.
    • (2002) Diabetes , vol.51 , pp. 3090-3094
    • Flyvbjerg, A.1    Dagnaes-Hansen, F.2    de Vriese, A.S.3    Schrijvers, B.F.4    Tilton, R.G.5    Rasch, R.6
  • 8
    • 33750713086 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice
    • Sung SH, Ziyadeh FN, Wang A, Pyagay PE, Kanwar YS, Chen S. Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. J Am Soc Nephrol. 2006;17:3093-3104.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3093-3104
    • Sung, S.H.1    Ziyadeh, F.N.2    Wang, A.3    Pyagay, P.E.4    Kanwar, Y.S.5    Chen, S.6
  • 9
    • 33747840984 scopus 로고    scopus 로고
    • Statins for diabetic cardiovascular complications
    • Ludwig S, Shen GX. Statins for diabetic cardiovascular complications. Curr Vasc Pharmacol. 2006;4:245-251.
    • (2006) Curr Vasc Pharmacol , vol.4 , pp. 245-251
    • Ludwig, S.1    Shen, G.X.2
  • 10
    • 0028019367 scopus 로고
    • The preventive effect of an HMG-CoA reductase inhibitor, pravastatin, on diabetic nephropathy in streptozotocin-diabetic rats
    • Kurata, H. The preventive effect of an HMG-CoA reductase inhibitor, pravastatin, on diabetic nephropathy in streptozotocin-diabetic rats. Jikeikai Med J. 1994;41:219-230.
    • (1994) Jikeikai Med J , vol.41 , pp. 219-230
    • Kurata, H.1
  • 11
    • 0037062481 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy
    • Danesh FR, Sadeghi MM, Amro N. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci USA. 2002;99:8301-8305.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8301-8305
    • Danesh, F.R.1    Sadeghi, M.M.2    Amro, N.3
  • 12
    • 33646501513 scopus 로고    scopus 로고
    • Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries
    • Lin CL, Wang FS, Kuo YR. Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries. Kidney Int. 2006;69:1593-1600.
    • (2006) Kidney Int , vol.69 , pp. 1593-1600
    • Lin, C.L.1    Wang, F.S.2    Kuo, Y.R.3
  • 13
    • 0344837811 scopus 로고    scopus 로고
    • Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    • Obrosova IG, Minchenko AG, Vasupuram R. Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes. 2003;52:864-871.
    • (2003) Diabetes , vol.52 , pp. 864-871
    • Obrosova, I.G.1    Minchenko, A.G.2    Vasupuram, R.3
  • 14
    • 0141640863 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
    • Yamakawa M, Liu LX, Date T, et al. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res. 2003;93:664-673.
    • (2003) Circ Res , vol.93 , pp. 664-673
    • Yamakawa, M.1    Liu, L.X.2    Date, T.3
  • 15
    • 33847130131 scopus 로고    scopus 로고
    • Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats
    • Mooradian AD, Haas MJ. Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats. Am J Ther. 2007;14:41-45.
    • (2007) Am J Ther , vol.14 , pp. 41-45
    • Mooradian, A.D.1    Haas, M.J.2
  • 16
    • 33645911208 scopus 로고    scopus 로고
    • Effect of pravastatin in people with diabetes and chronic kidney disease
    • Tonelli M, Keech A, Shepherd J, et al. Effect of pravastatin in people with diabetes and chronic kidney disease. J Am Soc Nephrol. 2005;16:3748-3754.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3748-3754
    • Tonelli, M.1    Keech, A.2    Shepherd, J.3
  • 17
    • 0038119554 scopus 로고    scopus 로고
    • Effects of the combination of an angiotensin II antagonist with an HMG-CoA reductase inhibitor in experimental diabetes
    • Qin J, Zhang Z, Liu J, et al. Effects of the combination of an angiotensin II antagonist with an HMG-CoA reductase inhibitor in experimental diabetes. Kidney Int. 2003;64:565-571.
    • (2003) Kidney Int , vol.64 , pp. 565-571
    • Qin, J.1    Zhang, Z.2    Liu, J.3
  • 18
    • 34447265300 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions
    • Liu E, Morimoto M, Kitajima S, et al. Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions. J Am Soc Nephrol. 2007;18:2094-2104.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2094-2104
    • Liu, E.1    Morimoto, M.2    Kitajima, S.3
  • 19
    • 33846701668 scopus 로고    scopus 로고
    • Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    • Nakagawa T, Sato W, Glushakova O, et al. Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol. 2007;18:539-550.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 539-550
    • Nakagawa, T.1    Sato, W.2    Glushakova, O.3
  • 21
    • 27744472350 scopus 로고    scopus 로고
    • HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation
    • Zeng L, Xu H, Chew TL, et al. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB J. 2005;19:1845-1847.
    • (2005) FASEB J , vol.19 , pp. 1845-1847
    • Zeng, L.1    Xu, H.2    Chew, T.L.3
  • 22
    • 0036087482 scopus 로고    scopus 로고
    • VEGF-induced mobilization of caveolae and increase in permeability of endothelial cells
    • Chen J, Braet F, Brodsky S, et al. VEGF-induced mobilization of caveolae and increase in permeability of endothelial cells. Am J Physiol Cell Physiol. 2001;282:C1053-C1063.
    • (2001) Am J Physiol Cell Physiol , vol.282
    • Chen, J.1    Braet, F.2    Brodsky, S.3
  • 23
    • 0037315103 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats
    • Usui H, Shikata K, Matsuda M, et al. HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats. Nephrol Dial Transplant. 2003;18:265-272.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 265-272
    • Usui, H.1    Shikata, K.2    Matsuda, M.3
  • 24
    • 0242720558 scopus 로고    scopus 로고
    • The role of lipids in the development of diabetic microvascular complications: Implications for therapy
    • Misra A, Kumar S, Kishore Vikram N, Kumar A. The role of lipids in the development of diabetic microvascular complications: implications for therapy. Am J Cardiovasc Drugs. 2003;3:325-338.
    • (2003) Am J Cardiovasc Drugs , vol.3 , pp. 325-338
    • Misra, A.1    Kumar, S.2    Kishore Vikram, N.3    Kumar, A.4
  • 25
    • 0344948143 scopus 로고    scopus 로고
    • Lovastatin and tumor necrosis factor-? exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis
    • Feleszko W, Balkowiec EZ, Sieberth E, et al. Lovastatin and tumor necrosis factor-? exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis. Int J Cancer. 1999;81:560-567.
    • (1999) Int J Cancer , vol.81 , pp. 560-567
    • Feleszko, W.1    Balkowiec, E.Z.2    Sieberth, E.3
  • 26
    • 0035957682 scopus 로고    scopus 로고
    • Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: Contribution to its antiangiogenic effect
    • Vincent L, Chen W, Hong L, et al. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: Contribution to its antiangiogenic effect. FEBS Lett. 2001;495:159-166.
    • (2001) FEBS Lett , vol.495 , pp. 159-166
    • Vincent, L.1    Chen, W.2    Hong, L.3
  • 27
  • 28
    • 2342640996 scopus 로고    scopus 로고
    • Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin
    • Jacobson JR, Dudek SM, Birukov KG, et al. Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004;30:662-670.
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 662-670
    • Jacobson, J.R.1    Dudek, S.M.2    Birukov, K.G.3
  • 29
    • 34547743999 scopus 로고    scopus 로고
    • Pitavastatin ameliorates albuminuria and renal mesangial expansion by down regulating NOX4 in db/db mice
    • Fujii M, Inoguchi T, Maeda Y, et al. Pitavastatin ameliorates albuminuria and renal mesangial expansion by down regulating NOX4 in db/db mice. Kidney Int. 2007;72:473-480.
    • (2007) Kidney Int , vol.72 , pp. 473-480
    • Fujii, M.1    Inoguchi, T.2    Maeda, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.