Thirteen-week oral toxicity of 1,4-dioxane in rats and mice

Journal of Toxicological Sciences

Volumn 33, Issue 2, 2008, Pages 141-153

  Kano, Hirokazu ^a   Umeda, Yumi ^a   Saito, Misae ^a   Senoh, Hideki ^a   Ohbayashi, Hisao ^a   Aiso, Shigetoshi ^a   Yamazaki, Kazunori ^a   Nagano, Kasuke ^a   Fukushima, Shoji ^a  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

Author keywords

1,4 dioxane; Liver; Mouse; Nasal cavity; Rat; Subchronic toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DIOXANE; DRINKING WATER; GLUCOSE; GLUTATHIONE TRANSFERASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; BRONCHODILATATION; CELL SWELLING; CHEMICAL CARCINOGENESIS; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY SIZE; LIVER CARCINOGENESIS; LIVER INJURY; LIVER NECROSIS; LIVER WEIGHT; LONG TERM EXPOSURE; LOWER RESPIRATORY TRACT; LUNG VOLUME; MALE; NONHUMAN; OLFACTORY EPITHELIUM; RAT; RESPIRATORY EPITHELIUM; RISK ASSESSMENT; TISSUE SECTION; UPPER RESPIRATORY TRACT;

MUS; RATTUS;

EID: 45749121838     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.33.141     Document Type: Article

References (40)

1. Aiso, S., Arito, H., Nishizawa, T., Nagano, K., Yamamoto, S. and Matsushima, T. (2005): Thirteen-week inhalation toxicity of p-dichlorobenzene in mice and rats. J. Occup. Health, 47, 249-260.
2. American Conference of Governmental Industrial Hygienists (ACGIH) (2001): 1,4-Dioxane. Documentation of the Threshold Limit Values and Biological Exposure Indices. ACGIH, Cincinnati, OH.
3. Argus, M.F., Arcos, J.C. and Hoch-Ligeti, C. (1965): Studies on the carcinogenic activity of protein-denaturing agents: Hepatocarcinogenicity of dioxane. J. Natl. Cancer Inst., 35, 949-958.
4. Argus, M.F., Sohal, R.S., Bryant, G.M., Hoch-Ligeti, C. and Arcos, J.C. (1973): Dose-response and ultrastructural alterations in dioxane carcinogenesis. Influence of methylcholanfhrene on acute toxicity. Europ. J. Cancer, 9, 237-243.
5. Chemical Daily (2006): 1,4-Dioxane. In Chemical Products Handbook 14906. pp.834-835, The Chemical Daily Co., Tokyo.
6. Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (2003): 1,4-Ddioxane. In Occupational Toxicants. Critical Data Evaluation for MAK Values and Classification of Carcinogens. Vol.20, (Greim, H. ed.), pp. 105-133, Wiley-VCH Verlag, Weinheim.
7. Dahl, A.R. and Hadley, W.M. (1991): Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants. Crit. Rev. Toxicol., 21, 345-372.
8. DeRosa, C.T., Wilbur, S., Holler, J., Richter, P. and Stevens, Y.W. (1996): Health evaluation of 1,4-dioxane. Toxicol. Ind. Health, 12, 1-43.
9. Fowlie, A.J., Grasso, P. and Benford, D.J. (1990): The short-term effects of carcinogens and sulphur dioxide on the nuclear size of rat nasal epithelial cells. J. Appl. Toxicol., 10, 29-38.
10. Grant, D. and Grasso, P. (1978): Suppression of HeLa cell growth and increase in nuclear size by chemical carcinogens: A possible screening method. Mutat. Res., 57, 369-380.
11. Hoch-Ligeti, C., Argus, M.F. and Arcos, J.C. (1970): Induction of carcinomas in the nasal cavity of rats by dioxane. Br. J. Cancer, 24, 164-167.
12. Inoue, T., Takeuchi, Y., Hisanaga, N., Ono, Y., Iwata, M., Ogata, M., Saito, K., Sakurai, H., Hara, I., Matsushita, T. and Ikeda, M. (1983): A nationwide survey on organic solvent components in various solvent products: Part 1. Homogeneous products such as thinners, degreasers and reagents. Ind. Health, 21, 175-183.
13. International Programme on Chemical Safety (IPCS) (1994): Environmental Health Criteria 170. Assessing Human Health Risks of Chemicals: Derivation of Guidance Values for Health-based Exposure Limits. WHO, Geneva.
14. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S. and Asamoto, M. (1988): Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats-an approach for a new medium-term bioassay system. Carcinogenesis, 9, 387-394.
15. Ito, N., Hasegawa, R., Imaida, K., Hirose, M., Shirai, T., Tamano, S. and Hagiwara, A. (1997): Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. J. Toxicol. Pathol, 10, 1-11.
16. Ito, N., Imaida, K., Asamoto, M. and Shirai, T. (2000): Early detection of carcinogenic substances and modifiers in rats. Mutat. Res., 462, 209-217.
17. Japan Ministry of the Environment (2002): Chemicals in the Environment, Fiscal Year 2001. Environmental Health and Safety Division, Environmental Health Department, Japan Ministry of the Environment.
18. Japan Ministry of the Environment (2007): Pollutant Release and Transfer Register, Fiscal Year 2005. Environmental Health and Safety Division, Environmental Health Department, Japan Ministry of the Environment. http://www.env.go.jp/chemi/prtr/result/gaiyo.html.
19. Japan Ministry of Health, Labour and Welfare (2003): Regulation of Tap Water, Ordinance No. 101, Water Supply Law.
20. Japan Society for Occupational Health (JSOH) (1984): 1,4-Dioxane. Documentation for recommendation of occupational exposure limit value. Jpn. J. Ind. Health, 26, 354-356.
21. Johnstone, R.T. (1959): Death due to Dioxane? AMA Arch. Ind. Health, 20, 445-447.
22. Kociba, R.J., McCollister, S.B., Park, C., Torkelson, T.R. and Gehring, P.J. (1974): 1,4-Dioxane I. Results of a 2-year ingestion study in rats. Toxicol. Appl. Pharmacol., 30, 275-286.
23. Kumai, M., Koizumi, A., Saito, K., Sakurai, H., Inoue, T., Takeuchi, Y., Hara, I., Ogata, M., Matsushita, T. and Ikeda, M. (1983): A nationwide survey on organic solvent components in various solvent products: Part 2. Heterogeneous products such as paints, inks and adhesives. Ind. Health, 21, 185-197.
24. Lundberg, I., Högberg, J., Kronevi, T. and Holmberg, B. (1987): Three industrial solvents investigated for tumor promoting activity in the rat liver. Cancer Lett., 36, 29-33.
25. Moore, M.A., Nakagawa, K., Satoh, K., Ishikawa, T. and Sato, K. (1987): Single GST-P positive liver cells - putative initiated hepatocytes. Carcinogenesis, 8, 483-486.
26. Nagano, K., Katagiri, T., Aiso, S., Senoh, H., Sakura, Y. and Takeuchi, T. (1997): Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice. Exp. Toxicol. Pathol., 49, 97-104.
27. National Cancer Institute (NCI) (1978): Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CAS No. 123-91-1). Technical Report Series No. 80. DHEW Publication No. (NIH) 78-1330. National Institutes of Health, Bethesda, MD.
28. National Institutes of Health (NIH) (1977): Guide for the Care and Use of Laboratory Animals. DHEW Publication No. (NIH) 77-23. Bethesda, MD.
29. National Institute for Occupational Safety and Health (NIOSH) (1977): Criteria for a Recommended Standard - Occupational Exposure to Dioxane. DHEW(NIOSH) Publication No. 77-226. U.S. Department Health, Education and Welfare, Center for Disease Control, NIOSH, Cincinnati, OH.
30. Organisation for Economic Co-operation and Development (OECD) (1981a): Guideline for Testing of Chemicals 408 for "Subchronic Oral Toxicity - Rodent: 90-day Study" Adopted May 1981. OECD, Paris.
31. Organisation for Economic Co-operation and Development (OECD) (1981b): The OECD Principles of Good Laboratory Practice. Adopted 1981. OECD, Paris.
32. Rowe, V.K. and Wolf, M.A. (1982): Dioxane. In Patty's Industrial Hygiene and Toxicology. (CLAYTON, G.D. and CLAYTON, F.E. eds.) Third Revised Edition. Vol. 2C, pp.3947-3958, John Wiley & Sons, New York.
33. Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M. and Ito, N. (1984): The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann, 75, 199-202.
34. Tatematsu, M., Mera, Y., Ito, N., Satoh, K. and Sato, K. (1985): Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis, 6, 1621-1626.
35. U.S. Environmental Protection Agency (U.S. EPA) (2007): 1,4-Dioxane. Integrated Risk Information System (IRIS). Washington DC, U.S. EPA. http://www.epa.gov/iris/subst/0326.htm.
36. Vyberg, M. and Nielsen, S. (1998): Dextran polymer conjugate two-step visualization system for immunohistochemistry. A comparison of EnVision+ with two three-step avidin-biotin techniques. Appl. Immunohistochem., 6, 3-10.
37. World Health Organization (WHO) (2005): 1,4-Dioxane in Drink ing Water. Background Document for Development of WHO Guidelines for Drinking-water Quality. WHO/SDE/WSH/05.08/120. WHO, Geneva.
38. Woo, Y.-T., Argus, M.F. and Arcos, J.C. (1978): Effect of mixed-function oxidase modifiers on metabolism and toxicity of the oncogen dioxane. Cancer Res., 38, 1621-1625.
39. Yamazaki, K., Ohno, H., Asakura, M., Narumi, A., Ohbayashi, H., Fujita, H., Ohnishi, M., Katagiri, T., Senoh, H., Yamanouchi, K., Nakayama, E., Yamamoto, S., Noguchi, T., Nagano, K., Enomoto, M. and Sakabe, H. (1994): Two-year toxicological and carcinogenesis studies of 1,4-dioxane in F344 rats and BDF1 mice. Drinking studies. Proceedings on the Second Asia-Pacific Symposium on Environmental and Occupational Health, Environmental and Occupational Chemical Hazards (2), pp. 193-198, Kobe University, Kobe.
40. Young, J.D., Braun, W.H. and Gehring, P.J. (1978): The dose-dependent fate of 1,4-dioxane in rats. J. Environ. Pathol. Toxicol., 2, 263-282.