Transmembrane domain interactions and residue proline 378 are essential for proper structure, especially disulfide bond formation, in the human vitamin K-dependent γ-glutamyl carboxylase

Biochemistry

Volumn 47, Issue 24, 2008, Pages 6301-6310

  Tie, Jian Ke ^a   Zheng, Mei Yan ^a   Hsiao, Kuang Ling N ^a   Perera, Lalith ^b   Stafford, Darrel W ^a   Straight, David L ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINES; ASSOCIATION REACTIONS; BIOLOGICAL MEMBRANES; CHEMICAL BONDS; FLOW INTERACTIONS; MICROFLUIDICS;

AMERICAN CHEMICAL SOCIETY (ACS); CHAIN STRUCTURES; DISULFIDE BOND FORMATION; DISULFIDE BONDS; ENDOPLASMIC RETICULUM (EI); GLYCINE RESIDUES; HOMOLOGY MODELING; NONCOVALENT ASSOCIATION; NONCOVALENT BONDS; POTENTIAL INTERACTIONS; PROLINE (PRO); PROPEPTIDE; SECOND TRANSMEMBRANE DOMAIN; TRANSMEMBRANE DOMAIN (TM3); TRANSMEMBRANE STRUCTURE; TWO CHAINS; TWO DOMAINS; VITAMIN K;

CELL MEMBRANES;

BLOOD CLOTTING FACTOR 9; MEMBRANE PROTEIN; PROLINE 378; PROLINE DERIVATIVE; VITAMIN K DEPENDENT CARBOXYLASE;

ARTICLE; DISULFIDE BOND; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CARBON-CARBON LIGASES; CELL MEMBRANE; DISULFIDES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROLINE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN K;

EID: 45749117530     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800235r     Document Type: Article

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