ECG and heart rate variability changes in preterm and near-term fetal lamb following LPS exposure

Reproductive Sciences

Volumn 15, Issue 6, 2008, Pages 572-583

  Blad, Sofia ^a   Welin, Anna Karin ^a   Kjellmer, Ingemar ^a   Rosen K G ^b   Mallard, Carina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Neoventa Medical AB   (Sweden)

Author keywords

Heart rate monitoring; Intrauterine infection; STAN

Indexed keywords

LIPOPOLYSACCHARIDE;

ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; FETUS ELECTROCARDIOGRAPHY; HEART HEMODYNAMICS; HEART RATE VARIABILITY; INTRAUTERINE INFECTION; NONHUMAN; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; SHEEP; ST SEGMENT; SURVIVAL; T WAVE;

ANIMALS; BLOOD GAS ANALYSIS; BLOOD GLUCOSE; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FEMALE; FETAL MONITORING; FETUS; HEART RATE, FETAL; LACTIC ACID; LIPOPOLYSACCHARIDES; PREGNANCY; SHEEP; SHEEP DISEASES;

EID: 45749107509     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107314060     Document Type: Article

References (38)

1. Goldenberg RL, Hauth JC, Andrews WW Intrauterine infection and preterm delivery. NEnglJMed. 2000 ; 342: 1500-1507.
2. Jacobsson B. Infectious and inflammatory mechanisms in preterm birth and cerebral palsy. Eur J Obstet Gynecol Reprod Biol. 2004 ; 115: 159-160.
3. Shim SS, Romero R., Hong JS, et al. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 2004 ; 191: 1339-1345.
4. Wu YW Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev. 2002 ; 8: 25-29.
5. Dammann O., Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr. 2000 ; 12: 99-104.
6. Eklind S., Mallard C., Leverin AL, et al. Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci. 2001 ; 13: 1101-1106.
7. Badawi N., Kurinczuk JJ, Keogh JM, et al. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ. 1998 ; 317: 1549-1553.
8. Parer JT, King T. Fetal heart rate monitoring: is it salvageable ? Am J Obstet Gynecol. 2000 ; 182: 982-987.
9. Althaus JE, Petersen SM, Fox HE, Holcroft CJ, Graham EM Can electronic fetal monitoring identify preterm neonates with cerebral white matter injury ? Obstet Gynecol. 2005 ; 105: 458-465.
10. Paul RH, Suidan AK, Yeh S., Schifrin BS, Hon EH Clinical fetal monitoring.VII.The evaluation and significance of intrapartum baseline FHR variability. Am J Obstet Gynecol. 1975 ; 123: 206-210.
11. Hopkins P., Outram N., Lofgren N., Ifeachor EC, Rosen KG A comparative study of fetal heart rate variability analysis techniques. Conf Proc IEEE Eng Med Biol Sci. 2006 ; 1: 1784-1787.
12. Noble D., Cohen I. The interpretation of the T wave of the electrocardiogram. Cardiovasc Res. 1978 ; 12: 13-27.
13. Westgate JA, Bennet L., Brabyn C., Williams CE, Gunn AJ ST waveform changes during repeated umbilical cord occlusions in near-term fetal sheep. Am J Obstet Gynecol. 2001 ; 184: 743-751.
14. Rosen KG, Hokegard KH, Kjellmer I. A study of the relationship between the electrocardiogram and hemodynamics in the fetal lamb during asphyxia. Acta Physiol Scand. 1976 ; 98: 275-284.
15. Amer-Wahlin I., Hellsten C., Noren H., et al. Cardiotocography only versus cardiotocography plus ST analysis of fetal electrocardiogram for intrapartum fetal monitoring: a Swedish randomised controlled trial. Lancet. 2001 ; 358: 534-538.
16. Noren H., Amer-Wahlin I., Hagberg H., et al. Fetal electrocardiography in labor and neonatal outcome: data from the Swedish randomized controlled trial on intrapartum fetal monitoring. Am J Obstet Gynecol. 2003 ; 188: 183-192.
17. Welin AK, Blad S., Hagberg H., Rosen KG, Kjellmer I., Mallard C. Electrocardiographic changes following umbilical cord occlusion in the midgestation fetal sheep. Acta Obstet Gynecol Scand. 2005 ; 84: 122-128.
18. Griffin MP, Moorman JR Toward the early diagnosis of neonatal sepsis and sepsis-like illness using novel heart rate analysis. Pediatrics. 2001 ; 107: 97-104.
19. Mallard C., Welin AK, Peebles D., Hagberg H., Kjellmer I. White matter injury following systemic endotoxemia or asphyxia in the fetal sheep. Neurochem Res. 2003 ; 28: 215-223.
20. Hull D., McIntyre J., Vinter J. Age-related changes in endotoxin sensitivity and the febrile response of newborn rabbits. Biol Neonate. 1993 ; 63: 370-379.
21. Cusumano V., Mancuso G., Genovese F., et al. Neonatal hypersusceptibility to endotoxin correlates with increased tumor necrosis factor production in mice. J Infect Dis. 1997 ; 176: 168-176.
22. Chorinchath BB, Kong LY, Mao L., McCallum RE Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice. J Immunol. 1996 ; 156: 1525-1530.
23. Elovitz MA, Mrinalini C., Sammel MD Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth. Pediatr Res. 2006 ; 59: 50-55.
24. Peebles DM, Miller S., Newman JP, Scott R., Hanson MA The effect of systemic administration of lipopolysaccharide on cerebral haemodynamics and oxygenation in the 0.65 gestation ovine fetus in utero. BJOG. 2003 ; 110: 735-743.
25. Court O., Kumar A., Parrillo JE Clinical review: myocardial depression in sepsis and septic shock. Crit Care. 2002 ; 6: 500-508.
26. Fleming I., Gray GA, Julou-Schaeffer G., Parratt JR, Stoclet JC Incubation with endotoxin activates the L-arginine pathway in vascular tissue. Biochem Biophys Res Commun. 1990 ; 171: 562-568.
27. Nuwayhid B., Brinkman CR III, Su C., Bevan JA, Assali NS Development of autonomic control of fetal circulation. Am J Physiol. 1975 ; 228: 337-344.
28. Di Giantomasso D., May CN, Bellomo R. Vital organ blood flow during hyperdynamic sepsis. Chest. 2003 ; 124: 1053-1059.
29. Coumans AB, Garnier Y., Supcun S., Jensen A., Berger R., Hasaart TH Nitric oxide and fetal organ blood flow during normoxia and hypoxemia in endotoxin-treated fetal sheep. Obstet Gynecol. 2005 ; 105: 145-155.
30. Widmark C., Jansson T., Lindecrantz K., Rosen KG ECG wave form, short term heart rate variability and plasma catecholamine concentrations in intrauterine growth-retarded guinea-pig fetuses. J Dev Physiol. 1990 ; 13: 289-293.
31. Wibbens B., Westgate JA, Bennet L., et al. Profound hypotension and associated electrocardiographic changes during prolonged cord occlusion in the near term fetal sheep. Am J Obstet Gynecol. 2005 ; 193: 803-810.
32. Thoren P. Reflex bradycardia elicited from left ventricular receptors during acute severe hypoxia in cats. Acta Physiol Scand. 1973 ; 87: 103-112.
33. Aghajani E., Korvald C., Nordhaug D., Sager G., Revhaug A., Myrmel T. E. coli sepsis induces profound mechanoenergetic inefficiency in the porcine left ventricle. Shock. 2004 ; 21: 103-109.
34. Sugi K., Newald J., Traber LD, et al. Cardiac dysfunction after acute endotoxin administration in conscious sheep. Am J Physiol. 1991 ; 260: H1474 - H1481.
35. Sosa G., Milstein JM, Bennett SH Escherichia coli endotoxin depresses left ventricular contractility in neonatal lambs. Pediatr Res. 1994 ; 35: 62-67.
36. Frantz S., Kobzik L., Kim YD, et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest. 1999 ; 104: 271-280.
37. Baumgarten G., Knuefermann P., Schuhmacher G., et al. Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock. 2006 ; 25: 43-49.
38. Tavener SA, Long EM, Robbins SM, McRae KM, Van Remmen H., Kubes P. Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res. 2004 ; 95: 700-707.