Miscoding properties of 6α- and 6β-diastereoisomers of the N2-(estradiol-6-yl)-2′-deoxyguanosine DNA adduct by Y-family human DNA polymerases

Biochemistry

Volumn 47, Issue 25, 2008, Pages 6695-6701

  Poon, Kinning ^a   Itoh, Shinji ^b   Suzuki, Naomi ^a   Laxmi, Y R Santosh ^a   Yoshizawa, Itsuo ^b   Shibutani, Shinya ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEIC ACIDS; ORGANIC ACIDS;

(PL) PROPERTIES; DIASTEREOISOMERS; DNA ADDUCTS; DNA DAMAGES; DNA SYNTHESIS; HUMAN DNA; REPRODUCTIVE ORGANS;

GENES;

DEOXYADENOSINE PHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEOXYGUANOSINE DERIVATIVE; DNA POLYMERASE; N 2 (ESTRADIOL 6 YL) 2' DEOXYGUANOSINE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OLIGOMER; PHOSPHORAMIDOUS ACID; THYMIDINE PHOSPHATE; ADENOSINE PHOSPHATE; CYTIDINE PHOSPHATE; DNA DIRECTED DNA POLYMERASE; DRUG DERIVATIVE; ESTRADIOL; GUANOSINE; N(2) (ESTRADIOL 6 YL) 2' DEOXYGUANOSINE; N(2)-(ESTRADIOL-6-YL)-2'-DEOXYGUANOSINE; NUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE;

ARTICLE; CATALYSIS; CHEMICAL PROCEDURES; DIASTEREOISOMER; DNA ADDUCT; GENETIC CODE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FAMILY; QUANTITATIVE ANALYSIS; STEADY STATE; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENE DELETION; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; STEREOISOMERISM;

ADENOSINE MONOPHOSPHATE; BASE SEQUENCE; CATALYSIS; CYTIDINE MONOPHOSPHATE; DNA ADDUCTS; DNA-DIRECTED DNA POLYMERASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTRADIOL; GUANOSINE; HUMANS; KINETICS; MOLECULAR STRUCTURE; MUTATION; NUCLEOTIDES; OLIGODEOXYRIBONUCLEOTIDES; SEQUENCE DELETION; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THYMIDINE MONOPHOSPHATE;

EID: 45749088069     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7022255     Document Type: Article

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