Defect in lipid rafts results in failed tolerance induction at the maternal-fetal interface: A possible cause for the recurrent spontaneous abortion

Medical Hypotheses

Volumn 71, Issue 2, 2008, Pages 275-278

  Chen, Li Juan ^a   Zhou, Hao ^a   Zou, Li ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HLA G ANTIGEN;

ARTICLE; CELL INTERACTION; HUMAN; LIPID RAFT; NATURAL KILLER CELL; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION; TROPHOBLAST;

ABORTION, HABITUAL; CELL MEMBRANE; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; MATERNAL-FETAL EXCHANGE; MEMBRANE MICRODOMAINS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PREGNANCY; UTERUS;

EID: 45649083472     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.11.018     Document Type: Article

References (15)

1. Trowsdale J., and Betz A.G. Mother's little helpers: mechanisms of maternal-fetal tolerance. Nat Immunol 7 3 (2006) 241-246
2. Hunt J.S., Petroff M.G., McIntire R.H., and Ober C. HLA-G and immune tolerance in pregnancy. FASEB J 19 7 (2005) 681-693
3. Pandey M.K., Rani R., and Agrawal S. An update in recurrent spontaneous abortion. Arch Gynecol Obstet 272 2 (2005) 95-108
4. Kano T., Mori T., Furudono M., et al. Human leukocyte antigen may predict outcome of primary recurrent spontaneous abortion treated with paternal lymphocyte alloimmunization therapy. Am J Reprod Immunol 58 4 (2007) 383-387
5. Yan W.H., Fan L.A., Yang J.Q., et al. HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion. Int J Immunogenet 33 1 (2006) 55-58
6. Koopman L.A., Kopcow H.D., Rybalov B., et al. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 198 8 (2003) 1201-1212
7. Patel R.N., Quack K.C., Hill J.A., et al. Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss. Mol Hum Reprod 9 9 (2003) 551-557
8. Quenby S., and Farquharson R. Uterine natural killer cells, implantation failure and recurrent miscarriage. Reprod Biomed Online 13 1 (2006) 24-28
9. Parham P. NK cells and trophoblasts: partners in pregnancy. J Exp Med 200 8 (2004) 951-955
10. Jury E.C., Flores-Borja F., and Kabouridis P.S. Lipid rafts in T cell signalling and disease. Semin Cell Dev Biol 18 5 (2007) 608-615
11. Michel V., and Bakovic M. Lipid rafts in health and disease. Biol Cell 99 3 (2007) 129-140
12. Comiskey M., Domino K.E., and Warner C.M. HLA-G is found in lipid rafts and can act as a signaling molecule. Hum Immunol 68 1 (2007) 1-11
13. Jury E.C., Kabouridis P.S., Flores-Borja F., et al. Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 113 8 (2004) 1176-1187
14. Krishnan S., Nambiar M.P., Warke V.G., et al. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 172 12 (2004) 7821-7831
15. Parikh R.M., Joshi S.R., Menon P.S., et al. Intensive glycemic control in diabetic pregnancy with intrauterine growth restriction is detrimental to fetus. Med Hypotheses 69 1 (2007) 203-205