메뉴 건너뛰기




Volumn 86, Issue 8, 2008, Pages 1823-1835

Ischemia-induced ribosomal protein S3 expressional changes and the neuroprotective effect against experimental cerebral ischemic damage

Author keywords

CA1 pyramidal cells; Neuroprotection; Pep 1 vector; Ribosomal protein S3; Transient forebrain ischemia

Indexed keywords

4 HYDROXY 2 NONNENAL; HYDROXYL GROUP; PROFILAGGRIN; PROTEIN PEP 1; PROTEIN S; PROTEIN S3;

EID: 45549103042     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21621     Document Type: Article
Times cited : (20)

References (57)
  • 1
    • 0042672758 scopus 로고    scopus 로고
    • 2 stimulation and hydroxyl radical generation in transient cerebral ischemia
    • 2 stimulation and hydroxyl radical generation in transient cerebral ischemia. J Neurosci Res 73:308-315.
    • (2003) J Neurosci Res , vol.73 , pp. 308-315
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 2
    • 31344432053 scopus 로고    scopus 로고
    • 2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
    • 2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic Biol Med 40:376-387.
    • (2006) Free Radic Biol Med , vol.40 , pp. 376-387
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 4
    • 3142683642 scopus 로고    scopus 로고
    • The protective effect of hypoxic preconditioning on cortical neuronal cultures is associated with increases in the activity of several anti-oxidant enzymes
    • Arthur PG, Lim SC, Meloni BP, Munns SE, Chan A, Knuckey NW. 2004. The protective effect of hypoxic preconditioning on cortical neuronal cultures is associated with increases in the activity of several anti-oxidant enzymes. Brain Res 1017:146-154.
    • (2004) Brain Res , vol.1017 , pp. 146-154
    • Arthur, P.G.1    Lim, S.C.2    Meloni, B.P.3    Munns, S.E.4    Chan, A.5    Knuckey, N.W.6
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 38349191031 scopus 로고    scopus 로고
    • Effective delivery of Pep-1-cargo protein into ischemic neurons and long-term neuroprotection of Pep-1-SOD1 against ischemic injury in the gerbil hippocampus
    • doi:10.1016/j.neuint.2007.08.013
    • Cho JH, Hwang IK, Yoo KY, Kim SY, Kim DW, Kwon YG, Choi SY, Won MH. 2007. Effective delivery of Pep-1-cargo protein into ischemic neurons and long-term neuroprotection of Pep-1-SOD1 against ischemic injury in the gerbil hippocampus. Neurochem Int doi:10.1016/j.neuint.2007.08.013.
    • (2007) Neurochem Int
    • Cho, J.H.1    Hwang, I.K.2    Yoo, K.Y.3    Kim, S.Y.4    Kim, D.W.5    Kwon, Y.G.6    Choi, S.Y.7    Won, M.H.8
  • 11
    • 0031714146 scopus 로고    scopus 로고
    • Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis
    • Chu CC, Paul WE. 1998. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol 35:487-502.
    • (1998) Mol Immunol , vol.35 , pp. 487-502
    • Chu, C.C.1    Paul, W.E.2
  • 12
    • 0032190895 scopus 로고    scopus 로고
    • Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8- hydroxydeoxyguanosine formation
    • Cordis GA, Maulik G, Bagchi D, Riedel W, Das DK. 1998. Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8- hydroxydeoxyguanosine formation. J Mol Cell Cardiol 30:1939-1944.
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 1939-1944
    • Cordis, G.A.1    Maulik, G.2    Bagchi, D.3    Riedel, W.4    Das, D.K.5
  • 14
    • 1042288299 scopus 로고    scopus 로고
    • Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis
    • Deshayes S, Heitz A, Morris MC, Charnet P, Divita G, Heitz F. 2004. Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis. Biochemistry 43:1449-1457.
    • (2004) Biochemistry , vol.43 , pp. 1449-1457
    • Deshayes, S.1    Heitz, A.2    Morris, M.C.3    Charnet, P.4    Divita, G.5    Heitz, F.6
  • 15
    • 0031455583 scopus 로고    scopus 로고
    • Characterization and mechanism of action of Drosophila ribosomal protein S3 DNA glycosylase activity for the removal of oxidatively damaged DNA bases
    • Deutsch WA, Yacoub A, Jaruga P, Zastawny TH, Dizdaroglu M. 1997. Characterization and mechanism of action of Drosophila ribosomal protein S3 DNA glycosylase activity for the removal of oxidatively damaged DNA bases. J Biol Chem 272:32857-32860.
    • (1997) J Biol Chem , vol.272 , pp. 32857-32860
    • Deutsch, W.A.1    Yacoub, A.2    Jaruga, P.3    Zastawny, T.H.4    Dizdaroglu, M.5
  • 16
    • 0037133957 scopus 로고    scopus 로고
    • Structure and function of the eukaryotic ribosome: The next frontier
    • Doudna JA, Rath VL. 2002. Structure and function of the eukaryotic ribosome: the next frontier. Cell 109:53-156.
    • (2002) Cell , vol.109 , pp. 53-156
    • Doudna, J.A.1    Rath, V.L.2
  • 18
    • 0035890197 scopus 로고    scopus 로고
    • Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons
    • Frantseva MV, Carlen PL, Perez Velazquez JL. 2001. Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons. Free Radic Biol Med 31:1216-1227.
    • (2001) Free Radic Biol Med , vol.31 , pp. 1216-1227
    • Frantseva, M.V.1    Carlen, P.L.2    Perez Velazquez, J.L.3
  • 20
    • 13844267505 scopus 로고    scopus 로고
    • Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation
    • Gordon KB, Macrae IM, Carswell HV. 2005. Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation. Brain Res 1036:155-162.
    • (2005) Brain Res , vol.1036 , pp. 155-162
    • Gordon, K.B.1    Macrae, I.M.2    Carswell, H.V.3
  • 21
    • 0038684215 scopus 로고    scopus 로고
    • Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    • Gustafsson E, Andsberg G, Darsalia V, Mohapel P, Mandel RJ, Kirik D, Lindvall O, Kokaia Z. 2003. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Eur J Neurosci 17:2667-2678.
    • (2003) Eur J Neurosci , vol.17 , pp. 2667-2678
    • Gustafsson, E.1    Andsberg, G.2    Darsalia, V.3    Mohapel, P.4    Mandel, R.J.5    Kirik, D.6    Lindvall, O.7    Kokaia, Z.8
  • 22
    • 0031792920 scopus 로고    scopus 로고
    • Reactive oxygen species and oxidative DNA damage
    • Hemnani T, Parihar MS. 1998. Reactive oxygen species and oxidative DNA damage. Indian J Physiol Pharmacol 42:440-452.
    • (1998) Indian J Physiol Pharmacol , vol.42 , pp. 440-452
    • Hemnani, T.1    Parihar, M.S.2
  • 23
    • 3343017389 scopus 로고    scopus 로고
    • Consequences of nonlytic membrane perturbation to the translocation of the cell penetrating peptide pep-1 in lipidic vesicles
    • Henriques ST, Castanho MA. 2004. Consequences of nonlytic membrane perturbation to the translocation of the cell penetrating peptide pep-1 in lipidic vesicles. Biochemistry 43:9716-9724.
    • (2004) Biochemistry , vol.43 , pp. 9716-9724
    • Henriques, S.T.1    Castanho, M.A.2
  • 24
    • 23044485527 scopus 로고    scopus 로고
    • Translocation of beta-galactosidase mediated by the cell-penetrating peptide pep-1 into lipid vesicles and human HeLa cells is driven by membrane electrostatic potential
    • Henriques ST, Costa J, Castanho MA. 2005a. Translocation of beta-galactosidase mediated by the cell-penetrating peptide pep-1 into lipid vesicles and human HeLa cells is driven by membrane electrostatic potential. Biochemistry 44:10189-10198.
    • (2005) Biochemistry , vol.44 , pp. 10189-10198
    • Henriques, S.T.1    Costa, J.2    Castanho, M.A.3
  • 25
    • 23644454418 scopus 로고    scopus 로고
    • Re-evaluating the role of strongly charged sequences in amphipathic cellpenetrating peptides: A fluorescence study using Pep-1
    • Henriques ST, Costa J, Castanho MA. 2005b. Re-evaluating the role of strongly charged sequences in amphipathic cellpenetrating peptides: a fluorescence study using Pep-1. FEBS Lett 579:4498-4502.
    • (2005) FEBS Lett , vol.579 , pp. 4498-4502
    • Henriques, S.T.1    Costa, J.2    Castanho, M.A.3
  • 27
    • 34547633289 scopus 로고    scopus 로고
    • Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil
    • Hwang IK, Yoo KY, Li H, Lee BH, Suh HW, Kwon YG, Won MH. 2007b. Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil. J Neurosci Res 85:2470-2479.
    • (2007) J Neurosci Res , vol.85 , pp. 2470-2479
    • Hwang, I.K.1    Yoo, K.Y.2    Li, H.3    Lee, B.H.4    Suh, H.W.5    Kwon, Y.G.6    Won, M.H.7
  • 28
    • 1342265497 scopus 로고    scopus 로고
    • rpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis
    • Jang CY, Lee JY, Kim J. 2004. rpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis. FEBS Lett 560:81-85.
    • (2004) FEBS Lett , vol.560 , pp. 81-85
    • Jang, C.Y.1    Lee, J.Y.2    Kim, J.3
  • 29
    • 0035980155 scopus 로고    scopus 로고
    • Yeast ribosomal protein S3 has an endonuclease activity on AP DNA
    • Jung SO, Lee JY, Kim J. 2001. Yeast ribosomal protein S3 has an endonuclease activity on AP DNA. Mol Cells 12:84-90.
    • (2001) Mol Cells , vol.12 , pp. 84-90
    • Jung, S.O.1    Lee, J.Y.2    Kim, J.3
  • 30
    • 0029073989 scopus 로고
    • Implication of mammalian ribosomal protein S3 in the processing of DNA damage
    • Kim J, Chubatsu LS, Admon A, Stahl J, Fellous R, Linn S. 1995. Implication of mammalian ribosomal protein S3 in the processing of DNA damage. J Biol Chem 270:13620-13629.
    • (1995) J Biol Chem , vol.270 , pp. 13620-13629
    • Kim, J.1    Chubatsu, L.S.2    Admon, A.3    Stahl, J.4    Fellous, R.5    Linn, S.6
  • 31
    • 0020051129 scopus 로고
    • Delayed neuronal death in the gerbil hippocampus following ischemia
    • Kirino T. 1982. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239:57-69.
    • (1982) Brain Res , vol.239 , pp. 57-69
    • Kirino, T.1
  • 32
    • 0034711454 scopus 로고    scopus 로고
    • Transduction of Cu,Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells
    • Kwon HY, Eum WS, Jang HW, Kang JH, Ryu J, Lee RB, Jin LH, Park J, Choi SY. 2000. Transduction of Cu,Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells. FEBS Lett 485:163-167.
    • (2000) FEBS Lett , vol.485 , pp. 163-167
    • Kwon, H.Y.1    Eum, W.S.2    Jang, H.W.3    Kang, J.H.4    Ryu, J.5    Lee, R.B.6    Jin, L.H.7    Park, J.8    Choi, S.Y.9
  • 33
    • 4444326084 scopus 로고    scopus 로고
    • Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils
    • Lee H, Bae JH, Lee SR. 2004. Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J Neurosci Res 77:892-900.
    • (2004) J Neurosci Res , vol.77 , pp. 892-900
    • Lee, H.1    Bae, J.H.2    Lee, S.R.3
  • 34
    • 0037443605 scopus 로고    scopus 로고
    • Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke
    • Liu S, Liu M, Peterson S, Miyake M, Vallyathan V, Liu KJ. 2003. Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke. J Neurosci Res 71:882-888.
    • (2003) J Neurosci Res , vol.71 , pp. 882-888
    • Liu, S.1    Liu, M.2    Peterson, S.3    Miyake, M.4    Vallyathan, V.5    Liu, K.J.6
  • 35
    • 0021742215 scopus 로고
    • Radiation resistance and the CuZn superoxide dismutase, Mn superoxide dismutase, catalase, and glutathione peroxidase activities of seven human cell lines
    • Marklund SL, Westman NG, Roos G, Carlsson J. 1984. Radiation resistance and the CuZn superoxide dismutase, Mn superoxide dismutase, catalase, and glutathione peroxidase activities of seven human cell lines. Radiat Res 100:115-123.
    • (1984) Radiat Res , vol.100 , pp. 115-123
    • Marklund, S.L.1    Westman, N.G.2    Roos, G.3    Carlsson, J.4
  • 36
    • 33746210833 scopus 로고    scopus 로고
    • Intrahippocampal injection of endothelin-1 in immature rats results in neuronal death, development of epilepsy and behavioral abnormalities later in life
    • Mátéffyová A, Otáhal J, Tsenov G, Mares P, Kubová H. 2006. Intrahippocampal injection of endothelin-1 in immature rats results in neuronal death, development of epilepsy and behavioral abnormalities later in life. Eur J Neurosci 24:351-360.
    • (2006) Eur J Neurosci , vol.24 , pp. 351-360
    • Mátéffyová, A.1    Otáhal, J.2    Tsenov, G.3    Mares, P.4    Kubová, H.5
  • 38
    • 0032972451 scopus 로고    scopus 로고
    • Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat
    • Nakashima M, Niwa M, Iwai T, Uematsu T. 1999. Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. Free Radic Biol Med 26:722-729.
    • (1999) Free Radic Biol Med , vol.26 , pp. 722-729
    • Nakashima, M.1    Niwa, M.2    Iwai, T.3    Uematsu, T.4
  • 39
    • 0021968895 scopus 로고
    • Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil
    • Nowak TS Jr, Fried RL, Lust WD, Passonneau JV. 1985. Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil. J Neurochem 44:487-494.
    • (1985) J Neurochem , vol.44 , pp. 487-494
    • Nowak Jr, T.S.1    Fried, R.L.2    Lust, W.D.3    Passonneau, J.V.4
  • 41
    • 0025744724 scopus 로고
    • Ribosomal protein genes are overexpressed in colorectal cancer: Isolation of a cDNA clone encoding the human S3 ribosomal protein
    • Pogue-Geile K, Geiser JR, Shu M, Miller C, Wool IG, Meisler AI, Pipas JM. 1991. Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol 11:3842-3849.
    • (1991) Mol Cell Biol , vol.11 , pp. 3842-3849
    • Pogue-Geile, K.1    Geiser, J.R.2    Shu, M.3    Miller, C.4    Wool, I.G.5    Meisler, A.I.6    Pipas, J.M.7
  • 42
    • 33745259502 scopus 로고    scopus 로고
    • Alpha-synuclein is up-regulated in neurones in response to chronic oxidative stress and is associated with neuroprotection
    • Quilty MC, King AE, Gai WP, Pountney DL, West AK, Vickers JC, Dickson TC. 2006. Alpha-synuclein is up-regulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. Exp Neurol 199:249-256.
    • (2006) Exp Neurol , vol.199 , pp. 249-256
    • Quilty, M.C.1    King, A.E.2    Gai, W.P.3    Pountney, D.L.4    West, A.K.5    Vickers, J.C.6    Dickson, T.C.7
  • 44
    • 0032562272 scopus 로고    scopus 로고
    • Induction of rat aortic smooth muscle cell growth by the lipid peroxidation product 4-hydroxy-2-nonenal
    • Ruef J, Rao GN, Li F, Bode C, Patterson C, Bhatnagar A, Runge MS. 1998. Induction of rat aortic smooth muscle cell growth by the lipid peroxidation product 4-hydroxy-2-nonenal. Circulation 97:1071-1078.
    • (1998) Circulation , vol.97 , pp. 1071-1078
    • Ruef, J.1    Rao, G.N.2    Li, F.3    Bode, C.4    Patterson, C.5    Bhatnagar, A.6    Runge, M.S.7
  • 45
    • 0030727940 scopus 로고    scopus 로고
    • The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity
    • Sandigursky M, Yacoub A, Kelley MR, Xu Y, Franklin WA, Deutsch WA. 1997. The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25:4557-4561.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4557-4561
    • Sandigursky, M.1    Yacoub, A.2    Kelley, M.R.3    Xu, Y.4    Franklin, W.A.5    Deutsch, W.A.6
  • 46
    • 0344585940 scopus 로고    scopus 로고
    • The interacting pathways for prevention and repair of oxidative DNA damage
    • Slupphaug G, Kavli B, Krokan HE. 2003. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res 531:231-251.
    • (2003) Mutat Res , vol.531 , pp. 231-251
    • Slupphaug, G.1    Kavli, B.2    Krokan, H.E.3
  • 47
    • 0034648748 scopus 로고    scopus 로고
    • Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain
    • Urabe T, Yamasaki Y, Hattori N, Yoshikawa M, Uchida K, Mizuno Y. 2000. Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain. Neuroscience 100:241-250.
    • (2000) Neuroscience , vol.100 , pp. 241-250
    • Urabe, T.1    Yamasaki, Y.2    Hattori, N.3    Yoshikawa, M.4    Uchida, K.5    Mizuno, Y.6
  • 49
    • 33744509306 scopus 로고    scopus 로고
    • Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    • Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, Sun GY. 2006. Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182-189.
    • (2006) Brain Res , vol.1090 , pp. 182-189
    • Wang, Q.1    Tompkins, K.D.2    Simonyi, A.3    Korthuis, R.J.4    Sun, A.Y.5    Sun, G.Y.6
  • 50
    • 28544450399 scopus 로고    scopus 로고
    • Biophysical and biological studies of end-group-modified derivatives of Pep-1
    • Weller K, Lauber S, Lerch M, Renaud A, Merkle HP, Zerbe O. 2005 Biophysical and biological studies of end-group-modified derivatives of Pep-1. Biochemistry 44:15799-15811.
    • (2005) Biochemistry , vol.44 , pp. 15799-15811
    • Weller, K.1    Lauber, S.2    Lerch, M.3    Renaud, A.4    Merkle, H.P.5    Zerbe, O.6
  • 51
    • 0033777909 scopus 로고    scopus 로고
    • Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-α in vitro
    • Wilde GJ, Pringle AK, Sundstrom LE, Mann DA, Iannotti F. 2000. Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-α in vitro. Eur J Neurosci 12:3863-3870.
    • (2000) Eur J Neurosci , vol.12 , pp. 3863-3870
    • Wilde, G.J.1    Pringle, A.K.2    Sundstrom, L.E.3    Mann, D.A.4    Iannotti, F.5
  • 53
    • 0035970836 scopus 로고    scopus 로고
    • The alterations of N-methyl-D-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult
    • Won MH, Kang T, Park S, Jeon G, Kim Y, Seo JH, Choi E, Chung M, Cho SS. 2001. The alterations of N-methyl-D-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult. Neurosci Lett 301:139-142.
    • (2001) Neurosci Lett , vol.301 , pp. 139-142
    • Won, M.H.1    Kang, T.2    Park, S.3    Jeon, G.4    Kim, Y.5    Seo, J.H.6    Choi, E.7    Chung, M.8    Cho, S.S.9
  • 54
    • 0029937632 scopus 로고    scopus 로고
    • A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities
    • Yacoub A, Augeri L, Kelley MR, Doetsch PW, Deutsch WA. 1996. A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities. EMBO J 15:2306-2312.
    • (1996) EMBO J , vol.15 , pp. 2306-2312
    • Yacoub, A.1    Augeri, L.2    Kelley, M.R.3    Doetsch, P.W.4    Deutsch, W.A.5
  • 55
    • 0018114449 scopus 로고
    • Experimental stroke in gerbils: Effect on translation and transcription
    • Yanagihara T. 1978. Experimental stroke in gerbils: effect on translation and transcription. Brain Res 158:435-444.
    • (1978) Brain Res , vol.158 , pp. 435-444
    • Yanagihara, T.1
  • 57
    • 34247227624 scopus 로고    scopus 로고
    • IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12
    • Zhang XM, Duan RS, Chen Z, Quezada HC, Mix E, Winblad B, Zhu J. 2007. IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12. Exp Neurol 205:64-73.
    • (2007) Exp Neurol , vol.205 , pp. 64-73
    • Zhang, X.M.1    Duan, R.S.2    Chen, Z.3    Quezada, H.C.4    Mix, E.5    Winblad, B.6    Zhu, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.